Evaluation of cholera vaccines formulated with toxin-coregulated pilin peptide plus polymer adjuvant in mice

Infection and Immunity

Volumn 69, Issue 12, 2001, Pages 7695-7702

  Wu, J Y ^a   Wade, W F ^a   Taylor, R K ^a  

^a DARTMOUTH MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL ANTIGEN; CHOLERA TOXIN; CHOLERA VACCINE; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G2A; IMMUNOGLOBULIN G2B; IMMUNOGLOBULIN G3; IMMUNOLOGICAL ADJUVANT; PILIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CHOLERA; CONTROLLED STUDY; DISULFIDE BOND; DRUG EFFICACY; DRUG FORMULATION; DRUG SCREENING; FEMALE; IMMUNE RESPONSE; IMMUNOGENICITY; IMMUNOGLOBULIN BLOOD LEVEL; MOUSE; NONHUMAN; PLACENTAL TRANSFER; PRIORITY JOURNAL; PROVOCATION TEST; TREATMENT OUTCOME; VACCINATION; VIBRIO CHOLERAE;

ADJUVANTS, IMMUNOLOGIC; ANIMALS; ANIMALS, NEWBORN; ANTIBODIES, BACTERIAL; BACTERIAL OUTER MEMBRANE PROTEINS; CHOLERA; CHOLERA VACCINES; FEMALE; FIMBRIAE PROTEINS; FIMBRIAE, BACTERIAL; LETHAL DOSE 50; MICE; PEPTIDE FRAGMENTS; POLYMERS; VACCINATION; VACCINES, SUBUNIT;

EID: 0035179236     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.69.12.7695-7702.2001     Document Type: Article

References (44)

1. Humoral immune responses in murine pregnancy. III. Relationship between anti-paternal alloantibody levels in maternal serum, placenta and fetus
2. The magnitude of the global problem of diarrhoeal disease: A ten-year update
3. Diversity of antibody-mediated immunity at the mucosal barrier
4. Lactogenic immunity in transgenic mice producing recombinant antibodies neutralizing coronavirus
5. The development of multivalent bovine rotavirus (strain WC3) reassortant vaccine for infants
6. Field trial of oral cholera vaccines in Bangladesh: Results from three-year follow-up
7. Immunologic correlates of protection against rotavirus challenge after intramuscular immunization of mice
8. Migration of antigen-presenting B cells from peripheral to mucosal lymphoid tissues may induce intestinal antigen-specific IgA following parenteral immunization
9. Molecular basis of vaccination
10. Dissociation of Escherichia coli heat-labile enterotoxin adjuvanticity from ADP-ribosyltransferase activity
11. Generalized systemic and mucosal immunity in mice after mucosal stimulation with cholera toxin
12. Cholera update and vaccination problems
13. Toxin, toxin-coregulated pili and the toxR regulon are essential for Vibrio cholerae pathogenesis in humans
14. Structure-function relationships of IgG subclasses
15. CTXφ immunity: Application in the development of cholera vaccines
16. Delineation of pilin domains required for bacterial association into microcolonies and intestinal colonization by Vibrio cholerae
17. Safety, immunogenicity, and efficacy of recombinant live oral cholera vaccines, CVD 103 and CVD 103-HgR
18. Live oral vaccines against cholera: An update
19. Adjuvants or live delivery systems for the characterization of mucosal T helper subset responses
20. New perspectives in mucosal immunity with emphasis on vaccine development
21. Increasing the immunogenicity of a trivalent influenza virus vaccine with adjuvant-active nonionic block copolymers for potential use in the elderly
22. B-cell activation in duodenal mucosa after oral cholera vaccination in IgA deficient subjects with or without IgG subclass deficiency
23. Protection against rotavirus-induced gastroenteritis in a murine model by passively acquired gastrointestinal but not circulating antibodies
24. Noninfectious rotavirus (strain RRV) induces an immune response in mice which protects against rotavirus challenge
25. Trivalent influenza vaccine
26. Watersoluble phosphazene polymers for parenteral and mucosal vaccine delivery
27. The effects of host age, virus dose, and virus strain on heterologous rotavirus infection of suckling mice
28. TcpA pilin sequences and colonization requirements for O1 and O139 Vibrio cholerae
29. Prevention of rotavirus-induced diarrhea in neonatal mice born to dams immunized with empty capsids of simian rotavirus SA-11
30. Structure and biogenesis of the type IV pili
31. Antibodies directed against the toxin-coregulated pilus isolated from Vibrio cholerae provide protection in the infant mouse experimental cholera model
32. Production and characterization of monoclonal antibodies to the toxin coregulated pilus (TCP) of Vibrio cholerae that protect against experimental cholera in infant mice
33. Localization of protective epitopes within the pilin subunit of the Vibrio cholerae toxin-coregulated pilus
34. Domains within the Vibrio cholerae toxin coregulated pilin subunit that mediate bacterial colonization
35. Oral combined B-subunitwhole cell cholera vaccine
36. Volunteer studies investigating the safety and efficacy of live oral El Tor Vibrio cholerae O1 vaccine strain CVD 111
37. Randomized, double-blind, placebo-controlled, multicentered trial of the efficacy of a single dose of live oral cholera vaccine CVD 103-HgR in preventing cholera following challenge with Vibrio cholerae O1 El Tor Inaba three months after vaccination
38. Onset and duration of protective immunity in challenged volunteers after vaccination with live oral cholera vaccine CVD 103-HgR
39. Investigation of the roles of toxin-coregulated pili and mannose-sensitive hemagglutinin pili in the pathogenesis of Vibrio cholerae O139 infection
40. Evaluation of a bivalent (CVD 103-HgR/CVD 111) live oral cholera vaccine in adult volunteers from the United States and Peru
41. The use of phoA gene fusions to identify a pilus colonization factor coordinately regulated with cholera toxin
42. Systematic development of a block copolymer adjuvant for trivalent influenza virus vaccine
43. Development of an adjuvant-active nonionic block copolymer for use in oil-free subunit vaccine formulations
44. Effects of a β-human chorionic gonadotropin subunit immunogen administered in aqueous solution with a novel nonionic block copolymer adjuvant in patients with advanced cancer