Investigation of the roles of toxin-coregulated pili and mannose- sensitive hemagglutinin pili in the pathogenesis of Vibrio cholerae O139 infection

Infection and Immunity

Volumn 66, Issue 2, 1998, Pages 692-695

  Tacket, Carol O ^a,c   Taylor, Ronald K ^b   Losonsky, Genevieve ^a   Lim, Y U ^a   Nataro, James P ^a   Kaper, James B ^a   Levine, Myron M ^a  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^b DARTMOUTH MEDICAL SCHOOL   (United States)

^c Center for Vaccine Development   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLERA TOXIN; HEMAGGLUTININ;

ACTIVE IMMUNIZATION; ANTIBODY RESPONSE; ANTIBODY TITER; ARTICLE; BACTERIAL COLONIZATION; BACTERIAL MUTATION; BACTERIAL VIRULENCE; BACTERIUM PILUS; CHOLERA; CLINICAL ARTICLE; DELETION MUTANT; HUMAN; INTESTINE EPITHELIUM; PRIORITY JOURNAL; VIBRIO CHOLERAE;

EID: 0031882526     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/iai.66.2.692-695.1998     Document Type: Article

References (24)

1. Allridge, S. R., P. A. Manning, J. Holmgren, and G. Jonson. 1996. Relative significance of mannose-sensitive hemagglutinin and toxin-coregulated pili in colonization of infanl mice by Vibrio cholerae F.I Tor. Infect. Immun. 64:3369-3373.
2. Attridge, S. R., E. Voss, and P. A. Manning. 1993 The role of toxin-coregu latcd pili in the pathogenesis of Vibno cholerae O1 El Tor. Microb. Pathog. 15:421-131.
3. Berche, P., C. Poyart, E. Abachin, H. Lelievre, J. Vandepitte, A. Dodin, and J.-M. Fornier. 1994. The novel epidemic strain O139 is closely related to the pandemic strain Ol of Vibrio cholerae. J. Infect. Dis. 170:701-704.
4. Clements, M. L., M. M. Levine, C. R. Young, R. E. Black, Y.-L. Lim, and R. M. Robins-Browne. 1982. Magnitude, kinetics and duration of vibriocidal antibody response in North Americans after ingestion of Vibro cholerae. J. Infect. Dis. 145:465-473.
5. Hall, R. H., F. M. Khambaty, M. H. Kothary, S. P. Keasler, and B. D. Tall. 1994. Vibrio cholerae non-O1 serogroup associated with cholera gravis genetically and physiologically resembles O1 El Tor cholera strains. Infect. Immun. 62:3859-3863.
6. Hall, R. H., C. Losonsky, A. P. D. Silveira, R. K. Taylor, J. J. Mekalanos, N. D. Witham, and M. M. Levine. 1991. Immunogenicity of Vibrio cholerae O1 toxin-coregulated pili in experimental and clinical cholera. Infect. Immun. 59:2508-2512.
7. Herrington, D. A., R. H. Hall, G. Losonsky, J. J. Mekalanos, R. K. Taylor, and M. M. Levine. 1988. Toxin, toxin-coregulated pili, and the toxR regulon are essential for Vibrio cholerae pathogenesis in humans. J. Exp. Med. 168:1487-1492.
8. Johnson, J. A., C. A. Salles, P. Panigrahi, M. J. Albert, A. C. Wright, R. J. Johnson, and J. G. Morris, Jr. 1994. Vibrio cholerae O139 synonym Bengal is closely related to Vibrio cholerae El Tor but has important differences. Infect. Immun. 62:2108-2110.
9. Jonson, G., J. Holmgren, and A.-M. Svennerbolm. 1991. Epitope differences in toxin-coregulated pili produced by classical and El Tor Vibro cholerae O1. Microb. Pathog. 11:179-188.
10. Jonson, G., J. Holmgren, and A.-M. Svennerholm. 1991. Identification of a mannose-binding pilus on Vibrio cholerae El Tor. Microb. Pathog. 11:433-441.
11. Levine, M., J. G. Morris, G. Losonsky, E. Boedeker, and B. Rowe. 1986. Fimbriae (pili) adhesins as vaccines, p. 143-145. In D. L. Lark, S. Normark. B.-E. Uhlin, and H. Wolf-Watz (ed.), Protein-carbohydrate interactions in biological systems. Academic Press, Inc., London, United Kingdom.
12. Levine, M. M., C. R. Young, R. E. Black, Y. Takeda, and R. A. Finkelstein. 1985. Enzyme-linked immunosorbent assay to measure antibodies to purified heat-labile enterotoxins from human and porcine strains of Escherichia colt and to cholera toxin: application in serodiagnosis and seroepidemiology J. Clin. Microbiol. 21:174-179.
13. Losonsky, G. A., Y. Lim, P. Motamedi, L. E. Comstock, J. A. Johnson, J. G. Morris, Jr., C. O. Tacket, J. B. Kaper, and M. M. Levine. 1997. Vibriocidal antibody responses in North American volunteers exposed to wild-type or vaccine Vibrio cholerae O139: specificity and relevance to immunity. Clin. Diagn. Lab. Immunol. 4:264-269.
14. Morris, J. G., G. A. Losonsky, J. A. Johnson, C. O. Tacket, J. P. Nataro, P. Panigrahi, and M. M. Levine. 1995. Clinical and immunologic characteristics of Vibrio cholerae O139 Bengal infection in North American volunteers. J. Infect. Dis. 171:903-908.
15. Osek, J., G. Jonson, A.-M. Svennerholm, and J. Holmgren. 1994. Role of antibodies against hiotype-specific V cholerae pili in protection against experimental classical and El Tor cholera. Infect. Immun. 62:2901-2907.
16. Rhine, J. A., and R. K. Taylor. 1994. TcpA pilin sequences and colonization requirements for O1 and O139 Vibrio cholerae. Mol. Microbiol. 13:1013-1020.
17. Sharma, D. P., C. Thomas, R. H. Hall, M. M. Levine, and S. R. Attridge. 1989. Significance of toxin-co-regulated pili as protective antigens of V. cholerae in the infant mouse model. Vaccine 7:451-456.
18. Sun, D., J. J. Mekalanos, and R. K.Taylor. 1990. Antibodies directed against the toxin-coregulated pilus isolated from Vibrio cholerae provide protection in the infant mouse experimental cholera model. J. Infect. Dis. 161:1231-1236.
19. Tacket, C. O., G. Losonsky, J. P. Nataro, L. Comstock, J. Michalski, R. Edelman, J. B. Kaper, and M. M. Lvine. 1995. Initial clinical studies of CVD 112 Vibrio cholerae O139 live oral vaccine: safety and efficacy against experimental challenge. J. Infect. Dis. 172:883-886.
20. Taylor, R. K., V. L. Miller, D. B. Furlong, and J. J. Mekalanos. 1987 Use of phoA gene fusions to identify a pilus colonization factor coordinately regulated with cholera toxin. Proc. Natl. Acad. Sci. USA 84:2833-2837.
21. Thelin, K. H., and R. K. Taylor. 1996. Toxin-coregulated pilus. but not mannose-sensitive hemagglutinin, is required for colonization by Vibrio cholerae O1 El Tor biotype and O139 strains. Infect. Immun. 64:2853-2856.
22. Voss, E., P. A. Manning, and S. R. Attridge. 1996. The toxin-coregulatcd pilus is a colonization factor and protective antigen of Vibrio cholerae El Tor. Microb. Pathog. 20:141-153.
23. Waldor, M. K., and J. J. Mekalanos. 1994. ToxR regulates virulence gene expression in non-O1 strains of Vibrio cholcrae that cause epidemic cholera. Infect. Immun. 62:72-78.
24. Waldor, M. K., and J. J. Mekalanos. 1996. Lysogenic conversion by a filamentous phage encoding cholera toxin. Science 272:1910-1924.