Tissue plasminogen activator inhibits P-glycoprotein activity in brain endothelial cells

European Journal of Pharmacology

Volumn 411, Issue 1-2, 2001, Pages

  Deli, Mária A ^a,b   Ábrahám, Csongor S ^a   Takahata, Hideaki ^a   Niwa, Masami ^a  

^a NAGASAKI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b INSTITUTE OF BIOCHEMISTRY   (Hungary)

Author keywords

Blood brain barrier; P glycoprotein; Tissue plasminogen activator

Indexed keywords

CYCLIC AMP; GLYCOPROTEIN P; PROTEIN KINASE C; RHODAMINE 123; TISSUE PLASMINOGEN ACTIVATOR;

ANIMAL CELL; ARTICLE; BLOOD BRAIN BARRIER; BRAIN CELL; CONTROLLED STUDY; DRUG EFFECT; DRUG PROTEIN BINDING; ENDOTHELIUM CELL; ENZYME ACTIVATION; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; BLOOD-BRAIN BARRIER; BRAIN; CELL LINE, TRANSFORMED; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIUM, VASCULAR; P-GLYCOPROTEINS; RHODAMINE 123; TISSUE PLASMINOGEN ACTIVATOR;

EID: 0035178147     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(00)00895-5     Document Type: Article

References (8)

1. Pentosan polysulfate regulates scavenger receptor-mediated, but not fluid-phase, endocytosis in immortalized cerebral endothelial cells
2. Ischaemic damage of brain microvessels: Inherent risk for thrombolytic treatment in stroke
3. Use of rhodamine 123 to examine the functional activity of P-glycoprotein in primary cultured brain microvessel endothelial cell monolayers
4. SV40 large immortalised cell lines of the rat blood-brain and blood-retinal barriers retain their phenotypic and immunological characteristics
5. Nonproteolytic neuroprotection by human recombinant tissue plasminogen activator
6. Dexamethasone regulation of P-glycoprotein activity in an immortalized rat brain endothelial cell line, GPNT
7. Blood-brain barrier function of P-glycoprotein
8. Tissue plasminogen activator (tPA) increases neuronal damage after focal cerebral ischemia in wild-type and tPA-deficient mice