Persistent viral load in patients on HAART is associated with a higher level of activation-induced apoptosis of CD4+ T cells

Journal of Antimicrobial Chemotherapy

Volumn 47, Issue 1, 2001, Pages 109-112

  Roger, Pierre Marie ^a   Breittmayer, Jean Philippe ^a   Cottalorda, Jacqueline ^b   Ticchioni, Michel ^a   Mondain, Véronique ^a   Dellamonica, Pierre ^a   Bernard, Alain ^a  

^a CENTRE HOSPITALIER UNIVERSITAIRE DE NICE   (France)

^b PASTEUR HOSPITAL   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIRETROVIRUS AGENT; CD4 ANTIGEN; NUCLEOSIDE ANALOG;

ADULT; APOPTOSIS; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; LYMPHOCYTOPENIA; MALE; MEASUREMENT; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; VIREMIA; VIRUS LOAD;

EID: 0035177277     PISSN: 03057453     EISSN: None     Source Type: Journal    
DOI: 10.1093/jac/47.1.109     Document Type: Article

References (10)

1. Treatment with indinavir, zidovudine and lamivudine in adults with human immunodeficiency virus infection and prior antiretroviral therapy
2. Immune restoration does not invariably occur following long-term HIV-1 suppression during antiretroviral therapy
3. Cross-linking of CD4 molecules upregulates Fas antigen expression in lymphocytes by inducing interferon-gamma and tumor necrosis factor-alpha secretion
4. gp120-induced programmed cell death in recently activated T cells without subsequent ligation of the T cell receptor
5. Sensitization of T cells to CD95-mediated apoptosis by HIV-1 Tat and gp120
6. + T cell apoptosis in HIV-infected patients
7. + human thymocytes with an intermediate CD3 density
8. Susceptibility of peripheral blood mononuclear cells to apoptosis is correlated to plasma HIV load
9. + antigen-specific T cells to undergo apoptosis by HIV-infected monocytes
10. HIV infection: How effective is drug combination treatment?