In-vitro analysis of the contribution of CYP2D6.35 to ultra-rapid metabolism

Pharmacogenetics

Volumn 11, Issue 8, 2001, Pages 739-741

  Allorge, D ^a   Harlow, J ^a   Boulet, O ^a   Hayhurst, G P ^a   Chowdry, J ^a   Roth, E ^a   Crewe, K ^a   Lo Guidice, J M ^a   Lhermitte, M ^a   Broly, F ^a   Tucker, G T ^a   Ellis, S W ^a  

^a ROYAL HALLAMSHIRE HOSPITAL   (United Kingdom)

Author keywords

Catalytic activity; CYP2D6.35; Debrisoquine; Ultra rapid metabolism

Indexed keywords

AMINO ACID; ARGININE; CYSTEINE; CYTOCHROME P450 2D6; METHIONINE; SERINE; THREONINE; VALINE;

ALLELE; AMINO ACID SUBSTITUTION; ARTICLE; CATALYSIS; ENZYME ACTIVITY; ENZYME METABOLISM; GENE AMPLIFICATION; GENE FUNCTION; IN VITRO STUDY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; YEAST;

ALLELES; AMINO ACID SUBSTITUTION; CYTOCHROME P-450 CYP2D6; EUROPEAN CONTINENTAL ANCESTRY GROUP; HUMANS; ISOENZYMES; METABOLIC CLEARANCE RATE;

EID: 0035175454     PISSN: 0960314X     EISSN: None     Source Type: Journal    
DOI: 10.1097/00008571-200111000-00014     Document Type: Article

References (11)

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2. Variable contribution of cytochrome P450 2D6, 2C9 and 3A4 to the 4-hydroxylation of tamoxifen by human liver microsomes
3. Ultrarapid hydroxylation of debrisoquine in a Swedish population. Analysis of the molecular genetic basis
4. Evidence that serine 304 is not a key ligand-binding residue in the active site of cytochrome P450 2D6
5. Assessment of the predictive power of genotypes for the in vivo catalytic activity of CYP2D6 in a German population
6. Influence of phenylalanine 481 substitutions on the catalytic activity of cytochrome P450 2D6
7. Inherited amplification of an active gene in the cytochrome P450 2D6 locus as a cause of ultrarapid metabolism of debrisoquine
8. Regioselective hydroxylation of debrisoquine by cytochrome P450 2D6: Implications for active site modelling
9. Polymorphisms in the CYP2D6 duplication-negative individuals with the ultrarapid metabolizer phenotype: A role for the CYP2D6*35 allele in ultrarapid metabolism?
10. Polymorphism of the cytochrome P450 CYP2D6 gene in a European population: Characterization of 48 mutations and 53 alleles, their frequencies and evolution
11. Cytochrome P450 2D6 variants in a Caucasian population: Allele frequencies and phenotype consequences