Inhibition of human cytomegalovirus replication in a human retinal epithelial cell model by antisense oligonucleotides

Investigative Ophthalmology and Visual Science

Volumn 42, Issue 1, 2001, Pages 163-169

  Detrick, B ^a   Nagineni, C N ^a   Grillone, L R ^a   Anderson, K P ^a   Henry, S P ^a   Hooks, J J ^a  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; FOMIVIRSEN; ISIS 13312;

ANTIVIRAL ACTIVITY; ARTICLE; CYTOMEGALOVIRUS; HUMAN; HUMAN CELL; PIGMENT EPITHELIUM; PRIORITY JOURNAL; RETINITIS; VIRUS REPLICATION;

ANTIVIRAL AGENTS; BLOTTING, SOUTHERN; CELLS, CULTURED; CYTOMEGALOVIRUS; CYTOPATHOGENIC EFFECT, VIRAL; DOSE-RESPONSE RELATIONSHIP, DRUG; FIBROBLASTS; HUMANS; OLIGONUCLEOTIDES, ANTISENSE; PIGMENT EPITHELIUM OF EYE; PLAQUE ASSAY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, VIRAL; THIONUCLEOTIDES; VIRUS REPLICATION;

EID: 0035173703     PISSN: 01460404     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (33)

1. Ocular manifestations of HIV infection
2. Cytomegalovirus retinitis and viral resistance: Ganciclovi resistance
3. Human immunodeficiency virus disease: Changing patterns of intraocular inflammation
4. Treatment of cytomegalovirus retinitis with ganciclovir
5. Foscarnet in the treatment of cytomegalovirus retinitis in acquired immune deficiency syndrome
6. Therapeutic implications of antisense oligonucleotides
7. Evaluation of retinal toxicity and efficacy of anti-cytomegalovirus and anti-herpes simplex virus antiviral phosphorothioate oligonucleotides ISIS 2922 and ISIS 4015
8. In vitro and in vivo pharmacologic activities of antisense oligunucleotides
9. Inhibition of herpes simplex virus type 2 growth by phosphorothioate oligodeoxynucleotides
10. Human cytomegalovirus infection decreases expression of thrombospondin-1 independent of the tumor suppressor protein p53
11. Inhibition of human cytomegalovirus immediate-early gene expression by an antisense oligonucleotide complementary to immediate-early RNA
12. Antiviral activity of a phosphorothioate oligonucleotide complementary to RNA of the human cytomegalovirus major immediate-early region
13. Antiviral activity of a phosphorothioate oligonucleotide complementary to human cytomegalovirus RNA when used in combination with antiviral nucleoside analogs
14. Human cytomegalovirus mutant with sequence-dependent resistance to the phosphorothioate oligonucleotide fomivirsen (ISIS 2922)
15. Pharmacokinetics of an antisense oligonucleotide injected intravitreally in monkeys
16. Pharmacokinetics of a potential human cytomegalovirus therapeutic, a phosphorothioate oligonucleotide, after intravitreal injection in the rabbit
17. Cytomegalovirus replication in human retinal pigment epithelial cells. Altered expression of viral early proteins
18. Cytomegalovirus retinitis in immunosuppressed hosts. II. Ocular manifestations
19. Demonstration of cytomegalovirus retinitis by in situ DNA hybridization
20. Cytomegalovirus replication in cultured human retinal pigment epithelial cells
21. Pathologic features of cytomegalovirus retinopathy after treatment with the antiviral agent ganciclovir
22. The retinal pigment epithelium: A versatile partner in vision
23. Pathophysiology of age-related macular degeneration
24. Entry of human cytomegalovirus into retinal pigment epithelial and endothelial cells by endocytosis
25. Role of IFN-gamma-induced indoleamine 2,3 dioxygenase and inducible nitric oxide synthase in the replication of human cytomegalovirus in retinal pigment epithelial cells
26. Accessory human cytomegalovirus glycoprotein US9 in the unique short component of the viral genome promotes cell-to-cell transmission of virus in polarized epithelial cells
27. Synergistic effects of gamma interferon on inflammatory mediators that induce interleukin-6 gene expression and secretion by human retinal pigment epithelial cells
28. Mechanisms of interferon-induced inhibition of Toxoplasma gondii replication in human retinal pigment epithelial cells
29. Inflammatory cytokines induce intercellular adhesion molecule-1 (ICAM-1) mRNA synthesis and protein secretion by human retinal pigment epithelial cell cultures
30. Toxoplasma gondii infection induces gene expression and secretion of interleukin 1 (IL-1), IL-6, granulocyte-macrophage colony-stimulating factor, and intercellular adhesion molecule 1 by human retinal pigment epithelial cells
31. Development and characterization of monoclonal antibodies directed against the retinal pigment epithelial cell
32. Growth kinetics of human cytomegalovirus are altered in monocyte-derived macrophages