Human cytomegalovirus mutant with sequence-dependent resistance to the phosphorothioate oligonucleotide fomivirsen (ISIS 2922)

Antimicrobial Agents and Chemotherapy

Volumn 42, Issue 4, 1998, Pages 971-973

  Mulamba, Gilbert B ^a   Hu, André ^a,c   Azad, Raana F ^b   Anderson, Kevin P ^b   Coen, Donald M ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b ISIS PHARMACEUTICALS   (United States)

^c RUTGERS ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FOMIVIRSEN;

ANTIVIRAL ACTIVITY; CROSS RESISTANCE; CYTOMEGALOVIRUS; DNA SEQUENCE; DRUG POTENCY; FIBROBLAST; GENE TARGETING; HUMAN; HUMAN CELL; NONHUMAN; NOTE; NUCLEOTIDE SEQUENCE; PREPUCE; PRIORITY JOURNAL; RETINITIS; VIRUS MUTATION;

EID: 0031978730     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/aac.42.4.971     Document Type: Note

References (14)

1. Anderson, K. P., M. C. Fox, V. Brown-Driver, M. J. Martin, and R. F. Azad. 1996. Inhibition of human cytomegalovirus immediate-early gene expression by an antisense oligonucleotide complementary to immediate-early RNA. Antimicrob. Agents Chemother. 40:2004-2011.
2. Azad, R. F., V. B. Driver, K. Tanaka, R. M. Crooke, and K. P. Anderson. 1993. Antiviral activity of a phosphorothioate oligonucleotide complementary to RNA of the human cytomegalovirus major immediate-early region. Antimicrob. Agents Chemother. 37:1945-1954.
3. Chiou, H. C., S. K. Weller, and D. M. Coen. 1985. Mutations in the herpes simplex virus major DNA-binding protein gene leading to altered sensitivity to DNA polymerase inhibitors. Virology 145:213-226.
4. Coen, D. M. 1991. Enzymatic amplification of DNA by PCR: standard procedures and optimization. In F. M. Ausubel, R. Brent, R. E. Kingston, D. D. Moore, J. A. Smith, J. G. Seidman, and K. Struhl (ed.), Current protocols in molecular biology. John Wiley & Sons, New York, N.Y.
5. Coen, D. M. 1991. The implications of resistance to antiviral agents for herpesvirus drug targets and drug therapy. Antivir. Res. 15:287-300.
6. Coen, D. M., H. E. Fleming, Jr., L. K. Leslie, and M. J. Retondo. 1985. Sensitivity of arabinosyladenine-resistant mutants of herpes simplex virus to other antiviral drugs and mapping of drug hypersensitivity mutations to the DNA polymerase locus. J. Virol. 53:477-488.
7. Herrmann, E. C., Jr., and J. A. Herrmann. 1977. A working hypothesis - virus resistance development as an indicator of specific antiviral activity. Ann. N. Y. Acad. Sci. 284:632-637.
8. Hu, A., and D. M. Coen. 1995. Unpublished results.
9. Monroe, J. E., R. Kilkuskie, A. K. Field, and C. Mulder. Personal communication.
10. Mulamba, G. B., A. Hu, and D. M. Coen. 1996. Unpublished results.
11. Richman, D. D. (ed.). 1996. Antiviral drug resistance. John Wiley & Sons, Chichester, United Kingdom.
12. Sullivan, V., K. K. Biron, C. Talarico, S. C. Stanat, M. Davis, L. M. Pozzi, and D. M. Coen. 1993. A point mutation in the human cytomegalovirus DNA polymerase gene confers resistance to ganciclovir and phosphonylmethoxyalkyl derivatives. Antimicrob. Agents Chemother. 37:19-25.
13. Sullivan, V., and D. M. Coen. 1991. Isolation of foscarnet-resistant human cytomegalovirus: patterns of resistance and sensitivity to other antiviral drugs. J. Infect. Dis. 164:781-784.
14. Tonkinson, J. L., and C. A. Stein. 1993. Antisense nucleic acids - prospects for antiviral intervention. Antiviral Chem. Chemother. 4:193-200.