The lipopolysaccharide co-receptor CD14 is present and functional in seminal plasma and expressed on spermatozoa

Immunology

Volumn 104, Issue 3, 2001, Pages 317-323

  Harris, Claire L ^a   Vigar, Miriam A ^a   Rey Nores, Julia E ^a   Horejsi, Vaclav ^b   Labeta, Mario O ^a   Paul Morgan, B ^a  

^a CARDIFF UNIVERSITY   (United Kingdom)

^b INSTITUTE OF MOLECULAR GENETICS   (Czech Republic)

Author keywords

[No Author keywords available]

Indexed keywords

CD14 ANTIGEN; GLYCOLIPID; LIPOPOLYSACCHARIDE; MEMBRANE PROTEIN; SPERM ANTIGEN;

AMNION FLUID LEVEL; ANTIGEN FUNCTION; ARTICLE; B LYMPHOCYTE ACTIVATION; BONE MARROW CELL; CELL ACTIVATION; CONTROLLED STUDY; HUMAN; HUMAN CELL; IMMUNITY; LYMPHOCYTE FUNCTION; MALE GENITAL SYSTEM; MILK LEVEL; MOLECULAR WEIGHT; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN CEREBROSPINAL FLUID LEVEL; PROTEIN EXPRESSION; PROTEIN LIPID INTERACTION; PROTEIN PURIFICATION; SEMINAL PLASMA; SPERMATOZOON; T LYMPHOCYTE ACTIVATION; ULTRACENTRIFUGATION; VASECTOMY;

ANTIGENS, CD14; BLOTTING, WESTERN; CHROMATOGRAPHY, AFFINITY; ENDOTOXINS; ENZYME-LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; HUMANS; MALE; MICROSCOPY, FLUORESCENCE; SEMEN; SOLUBILITY; SPERMATOZOA; VASECTOMY;

EID: 0035172533     PISSN: 00192805     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2567.2001.01312.x     Document Type: Article

References (36)

1. The CD14 monocyte differentiation antigen maps to a region encoding growth factors and receptors
2. CD14 is expressed and functional in human B cells
3. MD-2, a molecule that confers lipopolysaccharide responsiveness on Toll-like receptor 4
4. Endotoxin, toll-like receptor 4, and the afferent limb of innate immunity
5. Toll-like receptors in the induction of the innate immune response
6. Biochemical characterization of a soluble form of the 53-kDa monocyte surface antigen
7. Structural relationship between the soluble and membrane-bound forms of human monocyte surface glycoprotein CD14
8. Elevated levels of serum-soluble CD14 in human immunodeficiency virus type 1 (HIV-1) infection: Correlation to disease progression and clinical events
9. Pathological significance of elevated soluble CD14 production in rheumatoid arthritis: In the presence of soluble CD14, lipopolysaccharides at low concentrations activate RA synovial fibroblasts
10. Release from a human monocyte-like cell line of two different soluble forms of the lipopolysaccharide receptor, CD14
11. The two soluble forms of the lipopolysaccharide receptor, CD14: Characterization and release by normal human monocytes
12. Soluble CD14 participates in the response of cells to lipopolysaccharide
13. Toll-like receptor-4 mediates lipopolysaccharide-induced signal transduction
14. Cerebrospinal fluid levels of soluble CD14 in inflammatory and non-inflammatory diseases of the CNS. Upregulation during bacterial infections and viral meningitis
15. Lipopolysaccharide binding protein and soluble CD14 receptor protein in amniotic fluid and cord blood in patients at term
16. Innate recognition of bacteria in human milk is mediated by a milk-derived highly expressed pattern recognition receptor, soluble CD14
17. Soluble CD14 enriched in colostrum and milk induces B cell growth and differentiation
18. Immunomodulators in seminal plasma: A vital protection for spermatozoa in the presence of infection?
19. Infection and reactive oxygen species
20. Immunosuppressive mechanisms in semen: Implications for contraception
21. Physiologic relevance of the membrane attack complex inhibitory protein CD59 in human seminal plasma: CD59 is present on extracellular organelles (prostasomes), binds cell membranes, and inhibits complement-mediated lysis
22. Membrane attack complex (MAC)-mediated damage to spermatozoa: Protection of the cells by the presence on their membranes of MAC inhibitory proteins
23. Recognition of Gram-negative bacteria and endotoxin by the innate immune system
24. CD14 and innate recognition of bacteria
25. Lipopolysaccharide (LPS)-binding protein accelerates the binding of LPS to CD14
26. Soluble CD14 acts as a negative regulator of human T cell activation and function
27. Cutting edge: Human B cell function is regulated by interaction with soluble CD14: Opposite effects on IgG1 and IgE production
28. GPI-anchored complement regulatory proteins in seminal plasma. An analysis of their physical condition and the mechanisms of their binding to exogenous cells
29. CD14-mediated signal pathway of Porphyromonas gingivalis lipopolysaccharide in human gingival fibroblasts
30. CD14 expression and production by human hepatocytes
31. CD14-dependent lipopolysaccharide-induced β-defensin-2 expression in human tracheobronchial epithelium
32. Relative contribution of leukocytes and of spermatozoa to reactive oxygen species production in human sperm suspensions
33. Regional heterogeneity in intracellular distribution of superoxide and hydrogen peroxide within the sperm and its relation to sperm development
34. Generation of reactive oxygen species by leukocytes and sperm following exposure to urogenital tract infection
35. Involvement of serum and lipopolysaccharide in the production of interleukin-1- and interleukin-6-like molecules by human sperm cells
36. Granulocyte elastase indicates silent male genital tract inflammation and appropriate anti-inflammatory treatment