Derivatives of monoglycerides as apoptotic agents in T-cells

Cell Death and Differentiation

Volumn 8, Issue 11, 2001, Pages 1103-1112

  Philippoussis, F ^a,b,c   Przybytkowski, E ^b   Fortin, M ^a,b   Arguin, C ^a   Pande, S V ^b   Steff, A M ^a,b   Hugo, P ^a,b,c  

^a INSTITUTE FOR RESEARCH IN IMMUNOLOGY AND CANCER   (Canada)

^b CLIN RESEARCH INSTITUTE OF MONTREAL   (Canada)

^c MCGILL UNIVERSITY   (Canada)

Author keywords

Apoptosis; Cell death; Lipids; Monoglycerides; Thymocytes

Indexed keywords

APOPTOSIS INDUCING FACTOR; CALCIUM; CALCIUM CHELATING AGENT; CASPASE INHIBITOR; EGTAZIC ACID; FATTY ACID; GLYCEROL; LIPID; MONOACYLGLYCEROL; PROTEIN BCL 2; PROTEIN SYNTHESIS INHIBITOR; RNA;

ANIMAL CELL; APOPTOSIS; ARTICLE; CALCIUM TRANSPORT; CHEMICAL STRUCTURE; CONTROLLED STUDY; GENE OVEREXPRESSION; MAMMAL CELL; MOUSE; MOUSE STRAIN; NONHUMAN; PRIORITY JOURNAL; PROTEIN SYNTHESIS; RNA SYNTHESIS; T LYMPHOCYTE; THYMOCYTE;

ANIMALS; APOPTOSIS; CALCIUM; DIGLYCERIDES; FATTY ACIDS; GLYCERIDES; GLYCEROL; MICE; MICE, INBRED C57BL; T-LYMPHOCYTES; THYMUS GLAND;

EID: 0035171174     PISSN: 13509047     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.cdd.4400917     Document Type: Article

References (79)

1. Apoptosis in the pathogenesis and treatment of disease
2. Molecular and cellular mechanisms of T lymphocyte apoptosis
3. Death receptors: Signaling and modulation
4. CD95's deadly mission in the immune system
5. The Fas death factor
6. CD4+ CD8+ thymocytes are preferentially induced to die following CD45 cross-linking, through a novel apoptotic pathway
7. Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation
8. p53 is required for radiation-induced apoptosis in mouse thymocytes
9. Involvement of p85 in p53-dependent apoptotic response to oxidative stress
10. A matter of life and cell death
11. Defying death after DNA change
12. Ceramide in the eukaryotic stress response
13. Signal transduction of stress via ceramide
14. Programmed cell death induced by ceramide
15. Sphingosine and its methylated derivative N,N-dimethyl-sphingosine (DMS) induce apoptosis in a variety of human cancer cell lines
16. Requirement for GD3 ganglioside in CD95- and ceramide-induced apoptosis
17. Early and selective induction of apoptosis in human leukemic cells by the alkyl-lysophospholipid ET-18-OCH3
18. Selective induction of apoptosis in cancer cells by the ether lipid ET-18-OCH3 (Edelfosine): Molecular structure requirements, cellular uptake, and protection by Bcl-2 and Bcl-X(L)
19. Initiation of growth arrest and apoptosis of MCF-7 mammary carcinoma cells by tributyrin, a triglyceride analogue of the short-chain fatty acid butyrate, is associated with mitochondrial activity
20. Lysophosphatidic acid induces necrosis and apoptosis in hippocampal neurons
21. Lysophosphatidic acid and apoptosis of nerve growth factor-differentiated PC12 cells
22. Diversity of cellular receptors and functions for the lysophospholipid growth factors lysophosphatidic acid and sphingosine 1-phosphate
23. Molecular identification and characterization of G protein-coupled receptors for lysophosphatidic acid and sphingosine 1-phosphate
24. Structure of a cannabinoid receptor and functional expression of the cloned cDNA
25. Molecular characterization of a peripheral receptor for cannabinoids
26. Determination and characterization of a cannabinoid receptor in rat brain
27. Isolation and structure of a brain constituent that binds to the cannabinoid receptor
28. 2-Arachidonoylglycerol: A possible endogenous cannabinoid receptor ligand in brain
29. Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors
30. Anandamide induces apoptosis in human cells via vanilloid receptors. Evidence for a protective role of cannabinoid receptors
31. Anadamide, an endogenous cannabinoid receptor agonist inhibits lymphocyte proliferation and induces apoptosis
32. Anandamide induces apoptosis of PC-12 cells: Involvement of superoxide and caspase-3
33. Delta9-tetrahydrocannabinol induces apoptosis in C6 glioma cells
34. Hippocampal neurotoxicity of Delta9-tetrahydrocannabinol
35. Delta9-tetrahydrocannabinol induces apoptosis in human prostate PC-3 cells via a receptor-independent mechanism
36. Anti-tumoral action of cannabinoids: Involvement of sustained ceramide accumulation and extracellular signal-regulated kinase activation
37. 2-Arachidonoylglycerol, an endogenous cannabinoid receptor agonist: Identification as one of the major species of monoacylglycerols in various rat tissues, and evidence for its generation through mechanisms
38. Mono-, di- and triacylglycerol concentrations in human plasma: Effects of heparin injection and of a high-fat meal
39. Lysophosphatidic acid alters cerebrovascular reactivity in piglets
40. Increased lysophosphatidate levels in CSF after subarachnoid hemorrhage
41. The role of calcium in the regulation of apoptosis
42. The role of calcium in apoptosis
43. The role of intracellular free calcium mobilization in the mechanism of action of antitumour ether lipids SRI62-834 and ET18-OMe
44. Advances in the signal transduction of ceramide and related sphingolipids
45. Glucocorticoids in T cell development and function
46. Autocrine T-cell suicide mediated by APO-1/(Fas/CD95)
47. Cell-autonomous Fas (CD95)/Fas-ligand interaction mediates activation-induced apoptosis in T-cell hybridomas
48. Fas(CD95)/FasL interactions required for programmed cell death after T-cell activation
49. BCL-2 family members and the mitochondria in apoptosis
50. Bcl-2 proteins: Regulators of apoptosis or of mitochondrial homeostasis?
51. Role of the human heat shock protein hsp70 in protection against stress-induced apoptosis
52. BAD enables ceramide to signal apoptosis via Ras and Raf-1
53. Saturated but no mono-unsaturated fatty acids induce apoptotic cell death in neonatal rat ventricular myocytes
54. Palmitate induces apoptosis via a direct effect on mitochondria
55. Intracellular unesterified arachidonic acid signals apoptosis
56. Intracellular Ca2+ signals activate apoptosis in thymocytes: Studies using the Ca(2+)-ATPase inhibitor thapsigargin
57. Calcium dependence of glucocorticoid-induced lymphocytolysis
58. Glucocorticoids activate a suicide process in thymocytes through an elevation of cytosolic Ca2+ concentration
59. Elevations in cytosolic free Ca2+ are not required to trigger apoptosis in human leukaemia cells
60. Selective induction of apoptosis by capsaicin in transformed cells: The role of reactive oxygen species and calcium
61. The role of calcium in apoptosis
62. Dissociation of the effects of the antitumour ether lipid ET-18-OCH3 on cytosolic calcium and on apoptosis
63. A polymer-Triton X-100 conjugate capable of PH-dependent red blood cell lysis: A model system illustrating the possibility of drug delivery within acidic intracellular compartments
64. The detergent Triton X-100 induces a death pattern in human carcinoma cell lines that resembles cytotoxic lymphocyte-induced apoptosis
65. Deoxycholic acid and SCFA-induced apoptosis in the human tumor cell-line HT-29 and possible mechanisms
66. Possible mechanisms involved in apoptosis of colon tumor cell lines induced by deoxycholic acid, short-chain fatty acids, and their mixtures
67. Treatment of cells with detergent activates caspases and induces apoptotic cell death
68. Phosphatidate phosphohydrolase and signal transduction
69. Platelet-activating factor
70. Ceramide as a second messenger: Sticky solutions to sticky problems
71. Unidirectional membrane uptake of the ether lipid antineoplastic agent edelfosine by L1210 cells
72. Role of endocytosis in the action of ether lipids on WEHI-3B, HL60, and FDCP-mix A4 cells
73. Synthetic alkyl-phospholipid analogs; A new class of antitumor agents
74. Antitumor activity of monoglycerides and other esters of fatty acids
75. The major histocompatibility complex-restricted antigen receptor on T cells. I. Isolation with a monoclonal antibody
76. Characterization of a monoclonal antibody which detects all murine alpha beta T cell receptors
77. Improved method for measuring intracellular Ca++ with fluo-3
78. Early redistribution of plasma membrane phosphatidylserine is a general feature of apoptosis regardless of the initiating stimulus: Inhibition by overexpression of Bcl-2 and Abl
79. Specific activation of the cysteine protease CPP32 during the negative selection of T cells in the thymus