Dissociation of the effects of the antitumour ether lipid ET-18-OCH3 on cytosolic calcium and on apoptosis

British Journal of Pharmacology

Volumn 121, Issue 7, 1997, Pages 1364-1368

  Alonso, Maria Teresa ^a   Gajate, Consuelo ^a   Mollinedo, Faustino ^a   Modolell, Manuel ^b   Alvarez, Javier ^a   García Sancho, Javier ^a  

^a UNIVERSITY OF VALLADOLID   (Spain)

^b MAX PLANCK INSTITUTE OF IMMUNOBIOLOGY AND EPIGENETICS   (Germany)

Author keywords

Antitumour drug; Apoptosis; Cytosolic calcium; ET 18 OCH3; Ether lipids; PAF

Indexed keywords

ANTINEOPLASTIC AGENT; BEPAFANT; CALCIUM ION; DNA; EDELFOSINE; ETHER LIPID; THROMBOCYTE ACTIVATING FACTOR; THROMBOCYTE ACTIVATING FACTOR ANTAGONIST; THROMBOCYTE ACTIVATING FACTOR RECEPTOR;

APOPTOSIS; ARTICLE; CALCIUM CELL LEVEL; CELL STRAIN HL 60; CONTROLLED STUDY; DNA DEGRADATION; HUMAN; HUMAN CELL; LEUKEMIA CELL; NEUTROPHIL; PRIORITY JOURNAL;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CALCIUM; CYTOSOL; HL-60 CELLS; HUMANS; PHOSPHOLIPID ETHERS; PLATELET ACTIVATING FACTOR;

EID: 0030872157     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0701271     Document Type: Article

References (26)

1. 2+ stores. Biochem. J., 289, 761-766.
2. ANDREESEN, R., MODOLELL, M., WELTZIEN, H.U., EIBL, H., COMMON, H.H., LOHR, G.W. & MUNDER, P.G. (1978). Selective destruction of human leukemic cells by alkyl-lysophospholipids. Cancer Res., 38, 3894-3899.
3. 2+ concentration in a normal and a breast cancer cell line. Anticancer Res., 14, 1549-1556.
4. COLLINS, S.J., RUSCECHI, F.W., GALLAGER, R.E. & GALLO, R.C. (1987). Terminal differentiation of human promyelocytic leukemia cells induced by dimethylsulfoide and other polar compounds. Proc. Nat. Acad. Sci. U.S.A., 75, 2458-2462.
5. DIETZFELBINGER, H.F., KÜHN, D., ZAFFERANI, M., HANAUSKE, A.R., RASTETTER, J.W. & BERDEL, W.E. (1993). Removal of breast cancer cells from bone marrow by in vitro purging with ether lipids and cryopreservation. Cancer Res., 53, 3747-3751.
6. DIOMEDE, L., COLOTTA, F., PIOVANI, B., RE, F., MODEST, E.J. & SALMONA, M. (1993). Induction of apoptosis in human leukemic cells by the ether lipid 1-octadecyl-2-methyl-rac-glycero-3-phosphocholine. Int. J. Cancer, 53, 124 130.
7. GARCÍA, M.C., GARCIA, C., GIJON, M.A., FERNANDEZ-GALLARDO, S. MOLLINEDO, F. & SANCHEZ-CRESPO, M. (1991). Metabolism of platelet-activating factor in human hematopoietic cell lines. Differences between myeloid and lymphoid cells. Biochem. J., 273, 573-578.
8. 2+ indicators with greatly improved fluorescence properties. J. Biol. Chem., 260, 3440-3450.
9. HEUER, H.O., CASALS-STENZEL, J., MUACEVIC, G. & WEBER, K-H. (1990). Pharmacologic activity of bepafant (WEB 2170), a new and selective hetrazepinoic antagonist of platelet activating factor. J. Pharmacol. Exp. Ther., 255, 962-968.
10. HOULIHAN, W., LOHMEYER, M., WORKMAN, P. & CHEON, S.H. (1995). Phospholipid antitumour agents. Med. Res. Rev., 15, 157-223.
11. LAZEMBY, C.M., THOMPSON, M.G. & HICKMAN, J.A. (1990). Elevation of leukemic cell intracellular calcium by ether lipid SRI 62-837. Cancer Res., 50, 3327-3330.
12. LOHMEYER, M. & WORKMAN, P. (1993). The role of intracellular free calcium mobilization in the mechanism of action of antitumour ether lipids SRI 62-834 and ET18-OMe. Biochem. Pharmacol., 45, 77-86.
13. MCCONKEY, D.J. & ORRENIUS, S. (1994). Signal transduction pathways to apoptosis. Trends Cell Biol., 4, 370-375.
14. L. Cancer Res., 57, 1320-1328.
15. MOLLINEDO, F., GAJATE, C. & FLORES, I. (1994a). Involvement of phospholipase D in the activation of transcription factor AP-1 in human T lymphoid Jurkat cells. J. Immunol., 153, 2457-2469.
16. MOLLINEDO, F., GAJATE, C. & MODOLELL, M, (1994b). The ether lipid 1-octadecyl-2-methyl-rac-glycero-3-phosphocholine induces expression of fos and jun proto-oncogenes and activates AP-1 transcription factor in human leukemic cells. Biochem. J., 302, 325-329.
17. 3. Biochem. Biophys. Res. Commun., 192, 603-609.
18. MONTERO, M., ALVAREZ, J. & GARCÍA-SANCHO, J. (1991). Agonist-induced calcium influx in human neutrophils is secondary to the emptying of intracellular calcium stores. Biochem. J., 277, 73-79.
19. 2+ entry by ATP and UTP in promyelocytic leukemia HL60 cells. Biochem. J., 305, 879-887.
20. MÜLLER, E., DUPUIS, G., TURCOTTE, S. & ROLA-PLESZCZYNSKI, M. (1991). Human PAF receptor gene expression: induction during HL-60 cell differentiation. Biochem. Biophys. Res. Commun., 181, 1580-1586.
21. MUNDER, P.G. & WESTPHAL, O. (1990). Antitumoral and other biomedical activities of synthetic ether lysophospholipids. Chem. Immunol., 49, 206 235.
22. OKAMOTO, S., OLSON, A.C., VOGLER, W.R. & WINTON, E.F. (1987). Purging leukemic cells from stimulated human remission marrow with alkyl-lysophospholipid. Blood, 69, 1381 1387.
23. 2+ signalling by antitumour ether lipid analogues. Cancer Res., 50, 4458-4463.
24. VALLARI, D.S., SMITH, Z.L. & SNYDER, F. (1988). HL-60 cells become resistant towards antitumor ether-linked phopholipids following differentiation into a granulocytic form. Biochem. Biophys. Res. Commun., 156, 1-8.
25. VALLARI, D.S., AUSTINHIRST, R. & SNYDER, F. (1990). Development of specific functionally active receptors for platelet-activating factor in HL-60 cells following granulocytic differentiation. J. Biol. Chem., 265, 4261-4265.
26. VOGLER, W.R., BERDEL, W.E., OLSON, A.C., WINTON, E.F., HEFFNER, L.T. & GORDON, D.S. (1992). Autologous bone marrow transplantation in acute leukemia with marrow purged with alkyl-lysophospholipid. Blood, 80, 1423 1429.