Ligand binding to integrin αvβ3 requires tyrosine 178 in the αv subunit

Blood

Volumn 97, Issue 1, 2001, Pages 175-182

  Honda, Shigenori ^b   Tomiyama, Yoshiaki ^a   Pampori, Nisar ^b   Kashiwagi, Hirokazu ^b   Kiyoi, Teruo ^b   Kosugi, Satoru ^b   Tadokoro, Seiji ^b   Kurata, Yoshiyuki ^b   Shattil, Sanford J ^b   Matsuzawa, Yuji ^b  

^a OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

BETA3 INTEGRIN; INTEGRIN; TYROSINE;

AMINO ACID SEQUENCE; ANGIOGENESIS; ARTICLE; BINDING SITE; HEMOSTASIS; HUMAN; HUMAN CELL; LIGAND BINDING; PRIORITY JOURNAL;

EID: 0035166014     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.V97.1.175     Document Type: Article

References (50)

1. Integrins: Versatility, modulation, and signalling in cell adhesion
2. The platelet membrane glycoprotein llb-llla complex
3. 3 in vascular biology
4. 3 integrins are osleosclerotic because of dysfunctional osteoclasts
5. Comparison of cDNA-derived protein sequences of the human fibronectin and vibronectin receptor α-subunits and platelet glycoprotein llb
6. Regulation of vascular integrins
7. 3-integrins
8. New insights into integrin-ligand interaction
9. 2 integrins for interactions with intercellular adhesion molecule 1 (ICAM-1) and C3bl
10. A novel divalent cation-binding site in the A domain of the β2 integrin CR3 (CD11b/CD 18) is essential for ligand binding
11. Crystal structure of the a domain from the α subunit of integrin CR3 (CD11b/CD18)
12. 3 subunit
13. 5 subunits contain a metal ion-dependent adhesion site-like motif but lack an I domain
14. The ligand binding site of the platelet integrin receptor GPllb-llla is proximal to the second calcium binding domain of its α subunit
15. 3
16. llb, subunit is associated with a variant of Glanzmann thrombasthenia: Critical role of Asp163 in ligand binding
17. Glycoprotein llb Leu214Pro mutation produces Glanzmann thrombasthenia with both quantitative and qualitative abnormalities in GPllb/lla
18. 3 (glycoprotein llb-llla) to fibrinogen and ligand-mimetic antibodies (PAC-1, OPG-2 and LJ-CP3)
19. 3 identifies a novel region important for ligand binding
20. Folding of the N-terminal, ligand-binding region of integrin α-subunits into a β-propeller domain
21. 3)-ligand interaction: Identification of a heterodimeric RGD binding site on the vitronectin receptor
22. Human endothelial cells synthesize and express an Arg-Gly-Asp-directed adhesion receptor involved in attachment to fibrinogen and von Willebrand factor
23. 5: An adhesion receptor for vitronectin
24. 3 subunit
25. Selective inhibition of integrin function by antibodies specific for ligand-occupied receptor conformers
26. 3 (glycoprotien llb-llla) alter receptor affinity, specificity, and function
27. Quantitation of membrane glycoprotein llla on intact human platelets using the monoclonal antibody, AP3
28. 3 detected with a novel patch-engineered monovalent ligand
29. Changes in the platelet membrane glycoplotein llb-llIa complex during platelet activation
30. The anti-platelet and anti-thrombotic effects of FK633 a peptidemimetic GPllb/llla antagonist
31. Amino acid sequence of the vitronectin receptor α subunit and comparative expression of adhesion receptor mRNAs
32. 3 deficiensy in Glanzmann thrombasthenia
33. 3
34. 2+ signaling
35. 1: Regulation of the funtional response by soluble fibronectin
36. v subunit to form a novel vitronectin receptor in a human embryonic kidney cell line
37. Are changes in integrin affinity and conformation overemphasized?
38. 3 integrin mutation abolishes ligand binding and alters divalent cation-dependent conformation
39. 3 involves a discrete cation-binding site that regulates conformation
40. Differential effects of integrin α chain mutations on invasin and natural ligand interaction
41. 3 N-terminal repeats 2 and 3
42. 4 subunit in the upper face of the β-propeller mode1
43. 5 subunits
44. 3
45. A hot spot of binding energy in a hormone-receptor interface
46. 2-terminal repeats of the α subunit
47. 5 promote adenovirus internalization but not virus attachment
48. 3 (GPllb-llla) receptor function
49. 3
50. v integrins during angiogenesis: Insights into potential mechanisms of action and clinical development