RNA from heart of young and old rats leads to the expression of protein(s) in Xenopus oocytes that alter the transport activity of rat Na+,K+-ATPases differently

Pflugers Archiv European Journal of Physiology

Volumn 443, Issue 1, 2001, Pages 84-91

  Vasilets, L A ^a,b   Darmer, D ^a   Isenberg, G ^a   Schwarz, W ^c  

^a MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

^b INSTITUTE OF PROBLEMS OF CHEMICAL PHYSICS   (Russian Federation)

^c MAX PLANCK INSTITUTE OF BIOPHYSICS   (Germany)

Author keywords

Aging; Myocardium; Na+ pump; Rb+ flux; Voltage clamp

Indexed keywords

ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); ISOPROTEIN; POTASSIUM ION; RNA; RUBIDIUM; SODIUM ION;

AGE; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CORRELATION FUNCTION; ENZYME ACTIVITY; HEART LEFT VENTRICLE; HEART MUSCLE FIBER MEMBRANE POTENTIAL; ION TRANSPORT; NONHUMAN; OOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; VOLTAGE CLAMP; XENOPUS LAEVIS;

AGING; ANIMALS; BIOLOGICAL TRANSPORT; ELECTRIC CONDUCTIVITY; FEMALE; GENE EXPRESSION; MEMBRANE POTENTIALS; MYOCARDIUM; NA(+)-K(+)-EXCHANGING ATPASE; OOCYTES; OUABAIN; PATCH-CLAMP TECHNIQUES; RATS; RNA; RUBIDIUM RADIOISOTOPES; TRITIUM; XENOPUS LAEVIS;

EID: 0035165327     PISSN: 00316768     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004240100662     Document Type: Article

References (36)

1. + in isolated guinea-pig ventricular myocytes
2. Nonsynchronous changes in myocardial collagen mRNA and protein during ageing: Effect of DOCA-salt hypertension
3. Arrhythmogenicity of the hypertrophied and senescent heart and relationship to membrane proteins involved in the altered calcium handling
4. +)-ATPase activity in rat cardiac hypertrophy. Expression of the neonatal forms
5. Alteration of Na,K-ATPase subunit mRNA and protein levels in hypertrophied rat heart
6. The membrane proteins of the overloaded and senescent heart
7. Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease
8. +-free medium
9. +-ATPase isoforms expressed in Xenopus oocytes after co-injections of RNA from the heart of young and old rats
10. Extracellular access to the Na,K pump - Pathway similar to ion channel
11. Diminished inotropic responsiveness to ouabain in aged rat myocardium
12. Diminished inotropic responses but unaltered toxicity to acetylstrophanthidin in the senescent beagle
13. +-ATPase α-subunit gene expression in hypertension
14. Identification of a specific role for the Na,K-ATPase alpha 2 isoform as a regulator of calcium in the heart
15. + pump low and high ouabain affinity alpha-subunit isoforms are differently distributed in cells
16. Binding of ouabain to the Na-K-ATPase in oocytes of Xenopus taevis is voltage-independent
17. Cardiovascular regulatory mechanisms in advanced age
18. Identification of a phospholemman-like protein from shark rectal glands. Evidence for indirect regulation of the Na,K-ATPase by protein kinase C via a novel member of the FXYDY family
19. +/ouabain antagonism
20. +) ATPase form highly sensitive to ouabain
21. Steady-state and dynamic properties of cardiac sodium-calcium exchange: Ion and voltage dependencies of the transport cycle
22. Subcellular-distribution of sodium-pump isoform subunits in mammalian cardiac myocytes
23. Stoichiometry and voltage dependence of the sodium pump in voltage-clamped, internally dialyzed squid giant axon
24. +]
25. Ageing of the heart
26. +-ATPases with different affinities for ouabain: Developmental changes in immunologically different catalytic subunits
27. Two forms of the Na,K-ATPase catalytic subunit detected by their immunological and electrophoretic differences. Alpha and alpha+ in mammalian heart
28. Molecular mechanisms of myocardial remodelling
29. +-ATPase from mammalian kidney and Xenopus oocytes by protein kinases. Characterisation of the phosphorylation site for PKC
30. +-ATPase by protein kinases
31. +] is regulated by voltage-dependent gating
32. + pumps in Xenopus oocytes by membrane potential and stimulation of protein kinases
33. +-ATPase
34. + pump - Structure and function of the α-subunit
35. + pumps for transport activity and ouabain binding
36. +-ATPase is associated with the sites of cardiac and neuromuscular impulse transmission