The α3 isoform protein of the Na+,K+-ATPase is associated with the sites of cardiac and neuromuscular impulse transmission

Circulation Research

Volumn 78, Issue 5, 1996, Pages 870-879

  Zahler, Raphael ^a   Sun, Wei ^a   Ardito, T ^a   Zhang, Zhong Ting ^a   Kocsis, Jeffery D ^a   Kashgarian, Michael ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

cardiac conduction system; Na+,K+ ATPase isoform; neuromuscular junction

Indexed keywords

ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); BUNGAROTOXIN; ISOENZYME;

ANIMAL TISSUE; ANTIBODY SPECIFICITY; ARTICLE; DENERVATION; ENZYME ACTIVITY; HEART MUSCLE CELL; HEART MUSCLE CONDUCTION SYSTEM; IMMUNOHISTOCHEMISTRY; MEMBRANE POTENTIAL; NEUROMUSCULAR SYNAPSE; NEUROMUSCULAR TRANSMISSION; NONHUMAN; POSTSYNAPTIC MEMBRANE; PRIORITY JOURNAL; PROTEIN TRANSPORT; RAT; ANIMAL; COMPARATIVE STUDY; ENZYMOLOGY; HEART MUSCLE; MALE; METABOLISM; PHYSIOLOGY; SPRAGUE DAWLEY RAT; SYNAPTIC TRANSMISSION; WISTAR RAT;

ANIMALS; HEART CONDUCTION SYSTEM; IMMUNOHISTOCHEMISTRY; ISOENZYMES; MALE; MYOCARDIUM; NA(+)-K(+)-EXCHANGING ATPASE; NEUROMUSCULAR JUNCTION; RATS; RATS, SPRAGUE-DAWLEY; RATS, WISTAR; SYNAPTIC TRANSMISSION;

EID: 0029665094     PISSN: 00097330     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.RES.78.5.870     Document Type: Article

References (47)

1. Zahler R, Brines M, Kashgarian M, Benz EJ Jr, Gilmore-Hebert M. The cardiac conduction system in the rat expresses the α2 and α3 isoforms of the Na,K-ATPase. Proc Natl Acad Sci U S A. 1992; 89:99-103.
2. Brines ML, Gulanski BI, Gilmore-Hebert M, Greene AL, Benz EJ Jr, Robbins RJ. Cytoarchitectural relationships between ouabain binding and mRNA for isoforms of the sodium pump catalytic subunit in rat brain. Mol Brain Res. 1991;10:139-150.
3. Filuk PE, Miller MA, Dorsa DM, Stahl WL. Localization of messenger RNA encoding isoforms of the catalytic subunit of Na,K-ATPase in rat brain by in-situ hybridization histochemistry. Neurosci Res Commun. 1989;5:155-162.
4. McGrail KM, Phillips JM, Sweadner KJ. Immunofluorescent localization of three Na,K-ATPase isozymes in the rat central nervous system. J Neurosci. 1991;11:381-391.
5. Siegel GJ, Mata M, Hieber V, Fink DJ. α1 and α3 isoforms of Na,K-ATPase are both produced in neurons and show unique distributions in rat CNS and PNS. In: The Sodium Pump: Recent Developments. New York, NY: Rockefeller University Press; 1991: 143-147.
6. Takeyasu K, Mizushima A, Barnstein AM, Hamrick M, Fambrough DM. Stability of Na,K-ATPase a-subunit isoforms in evolution. Am J Physiol. 1990;259:C619-C630.
7. Jones SW, Salpeter M, ed. The Vertebrate Neuromuscular Junction. New York, NY: Alan R Liss Inc; 1987:187-246.
8. Sweadner KJ. Isozymes of the Na,K-ATPase. Biochim Biophys Acta. 1989;988:185-220.
9. Brines ML, Robbins RJ. Cell-specific expression of Na,K-ATPase catalytic subunits in cultured neurons and glia: evidence for polarized distribution in neurons. Brain Res. 1993;631:1-11.
10. Pietrini G, Matteoli M, Banker G, Caplan MJ. Isoforms of the Na,K-ATPase are present in both axons and dendrites of hippocampal neurons in culture. Proc Natl Acad Sci USA. 1992;89: 8414-8418.
11. Kashgarian M, Biemesderfer D, Forbush B, Caplan. M. Monoclonal antibody to Na,K-ATPase: immunocytochemical localization along nephron segments. Kidney Int. 1985;28:899-913.
12. Bjornskov EK, Norris FH, Mower-Kuby J. Histochemical staining of the acetylcholine receptor, acetylcholinesterase, and the axon terminal. Muscle Nerve. 1982;5:140-142.
13. Sanes JR, Engvall E, Butkowski R, Hunter DD. Molecular heterogeneity of basal laminae: isoforms of laminin and collagen IV at the neuromuscular junction and elsewhere. J Cell Biol. 1990;111: 1685-1699.
14. Gros D, Jarry-Guichard T, Ten Velde I, de Maziere A, van Kempen MJA, Davoust J, Briand JP, Moorman AFM, Jongsma HJ. Restricted distribution of connexin40, a gap junctional protein, in mammalian heart. Circ Res. 1994;74:839-851.
15. Raff MC, Fields KL, Hakomori S, Mirsky R, Pruss RM, Winter J. Cell-type-specific markers for distinguishing and studying neurons and the major classes of glial cells in culture. Brain Res. 1979;174: 283-308.
16. Schneider BG, Kraig E. Na,K-ATPase of the photoreceptor: selective expression of α3 and β2 isoforms. Exp Eye Res. 1990;51: 553-561.
17. Forbush BI. Assay of Na,K-ATPase in plasma membrane preparations. Anal Biochem. 1982;128:159-163.
18. Jewell EA, Lingrel JB. Comparison of substrate dependence properties of the rat Na,K-ATPase α1, α2, and α3 isoforms expressed in HeLa cells. J Biol Chem. 1991;266:16925-16930.
19. Gourdie RG, Severs NJ, Green CR, Rothery S, Germroth P, Thompson RP. The spatial distribution and relative abundance of gap-junctional connexin40 and connexin43 correlate to functional properties of components of the cardiac AV conduction system. J Cell Sci. 1993;105:985-991.
20. +-ATPase is associated with the sites of neuromuscular and cardiac impulse transmission. In: Bamberg E, Schoner W, eds. The Sodium Pump: Structure, Mechanism, Hormonal Control and its Role in Disease. New York, NY: Springer-Verlag; 1994:714-717.
21. Sommer JR, Johnson EA. Ultrastructure of cardiac muscle. In: Handbook of Physiology. Section 1. Bethesda, Md: American Physiological Society; 1979:113-186.
22. Zahler R, Sun W, Ardito T, Brines M, Kashgarian M. Na,K-ATPase α isoform protein expression in heart and vascular endothelium: cellular and developmental regulation. Am J Physiol. 1996; 270:C361-C371.
23. Lingrel JB, Orlowski J, Shull MM, Price EM. Molecular genetics of the Na,K-ATPase. Prog Nucleic Acid Res Mol Biol. 1990;38:37-89.
24. Ohlendieck K, Ervasti JM, Matsumara K, Kahl SD, Leveille CJ, Campbell KP. Dystrophin-related protein is localized to neuromuscular junctions of adult skeletal muscle. Neuron. 1991;7: 499-508.
25. Ko PK, Anderson MJ, Cohen MW. Denervated skeletal muscle fibers develop discrete patches of high acetylcholine receptor density. Science. 1977;196:540-542.
26. Kirby ML. Cardiac morphogenesis: recent research advances. Pediatr Res. 1987;21:219-224.
27. Polimeni PI, Vassalle M. On the mechanism of ouabain toxicity in Purkinje and ventricular muscle fibers at rest and during activity. Am J Cardiol. 1971;27:622-628.
28. Somberg JC, Barry WH, Smith TW. Differing sensitivities of Purkinje fibers and myocardium to inhibition of monovalent cation transport by digitalis. J Clin Invest. 1981;67:116-123.
29. Clerc L. Directional differences of impulse spread in trabecular muscle from mammalian heart. J Physiol (Lond). 1976;255:335-346.
30. Weidmann S. The electrical constants of Purkinje fibers. J Physiol (Lond). 1952;118:348-360.
31. Riker WF, Okamoto M, Artusio JF. The interactions of ouabain with post-tetanic and facilitory drug potentiations at cat soleus neuromuscular junctions in vivo. Neurochem Res. 1990;15:457-465.
32. Bowman WC. Pharmacology of Neuromuscular Function. London, UK: John Wright and Sons; 1990:15.
33. Betz WJ, Caldwell JH, Ribchester RR, Robinson KR, Stump RF. Endogenous electric field around muscle fibers depends on the Na,K pump. Nature. 1980;287:235-237.
34. Blaustein MP. Physiological effects of endogenous ouabain. Am J Physiol. 1993;264:C1367-C1387.
35. Bostock H, Grafe P. Activity-dependent excitability changes in normal and demyelinated rat spinal root axons. J Physiol (Lond). 1985;365:239-257.
36. Gordon TR, Kocsis JD, Waxman SG. Electrogenic pump (Na,K-ATPase) activity in rat optic nerve. Neuroscience. 1990;37:829-837.
37. Kocsis JD, Malenka RC, Waxman SG. Effects of extracellular potassium concentration on the excitability of the parallel fibers of the rat cerebellum. J Physiol (Lond). 1983;334:225-244.
38. Zahler R, Jewell E, Lingrel J, Zhang DH, Bang E, Boron WF. Sodium kinetics of individual Na,K-ATPase isoforms measured in intact transfected cells. Clin Res. 1995;43:268A. Abstract.
39. Ferns MJ, Hall ZW. How many agrins does it take to make a synapse? Cell. 1992;70:1-3.
40. Shyjian AW, Canfield VA, Levenson R. Functional properties of the Na,K-ATPase α2-subunit isoform expressed in mammalian cell lines. In: De Weer P, Kaplan J, eds. The Sodium Pump: Recent Developments. New York, NY: Rockefeller University Press; 1991: 131-136.
41. Gloor S, Antonicek H, Sweadner KJ, Pagliusi S, Frank R, Moos M, Schachner M. The adhesion molecule on glia (AMOG) is a homologue of the β subunit for the Na,K-ATPase. J Cell Biol. 1990; 110:165-174.
42. Lombet A, Mourre R, Laduron P, Jacomet Y, Lazdunski. M. Axonal transport of Na,K-ATPase identified as a ouabain binding site in sciatic nerve. Neurosci Lett. 1986;64:177-183.
43. Mata M, Siegel GJ, Hieber V, Beaty MW, Fink DJ. Differential distribution of Na,K-ATPase alpha isoform mRNA's in peripheral nervous system. Brain Res. 1991;546:47-54.
44. Specht SC, Sweadner KJ. Two different Na,K-ATPases in the optic nerve. Proc Natl Acad Sci USA. 1984;81:1234-1238.
45. Munzer JS, Daly SE, Jewell-Motz EA, Lingrel JB, Blostein R. Tissue- and isoform-specific kinetic behavior of the Na,K-ATPase. J Biol Chem. 1994;269:16668-16676.
46. Canfield V, Emanuel JR, Spickofsky N, Levenson R, Margolskee RF. Ouabain-resistant mutants of the rat Na,K-ATPase α2 isoform identified by using an episomal expression vector. Mol Cell Biol. 1990;10:1367-1372.
47. Kent RB, Emanuel JR, Ben Neriah Y, Levenson R, Housman DE. Ouabain resistance conferred by expression of the cDNA for a murine Na,K-ATPase α subunit. Science. 1987;237:901-903.