Peptide generation in the major histocompatibility complex class I antigen processing and presentation pathway

Current Opinion in Hematology

Volumn 8, Issue 1, 2001, Pages 12-16

  Androlewicz, Matthew J ^a  

^a H LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL PROTEIN; CHAPERONE; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; PROTEASOME; UBIQUITIN;

ANTIGEN PRESENTATION; CYTOSOL; MAJOR HISTOCOMPATIBILITY COMPLEX; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PROCESSING; PROTEIN TRANSPORT; REVIEW; RIBOSOME;

ANIMALS; ANTIGEN PRESENTATION; CYSTEINE ENDOPEPTIDASES; HISTOCOMPATIBILITY ANTIGENS CLASS I; HUMANS; MULTIENZYME COMPLEXES; PEPTIDES; PROTEASOME ENDOPEPTIDASE COMPLEX; SIGNAL TRANSDUCTION;

EID: 0035164873     PISSN: 10656251     EISSN: None     Source Type: Journal    
DOI: 10.1097/00062752-200101000-00003     Document Type: Review

References (40)

1. Proteasomes and antigen processing
2. The genetics of proteasomes and antigen processing
3. Peptide antigen production by the proteasome: Complexity provides efficiency
4. A role for the ubiquitin-dependent proteolytic pathway in MHC class I-restricted antigen presentation
5. Rate of antigen degradation by the ubiquitin-proteasome pathway influences MHC class I presentation
6. Intracellular localization of proteasomal degradation of a viral antigen
7. Transporter-independent processing of HIV-1 envelope protein for recognition by CD8+ T cells
8. An epitope-selective, transporter associated with antigen presentation (TAP)-1/2-independent pathway and a more general TAP-1/2-dependent antigen-processing pathway allow recognition of the HIV-1 envelope glycoprotein by CD8+ CTL
9. A proteaseome-related gene between the two ABC transporter loci in the class II region of the human MHC
10. Structural and serological similarity of MHC-linked LMP and proteasome (multicatalytic proteinase) complexes
11. Subunit of the '20S' proteasome (multicatalytic proteinase encoded by the major histocompatibility complex
12. MHC-linked LMP gene products specifically alter peptidase activities of the proteasome
13. γ-interferon and expression of MHC genes regulate peptide hydrolysis by proteasomes
14. Proteasome subunits encoded in the MHC are not generally required for the porcessing of the peptides bound by MHC class I molecules
15. Proteasome subunits encoded by the major histocompatibility complex are not essential for antigen presentation
16. Altered peptidase and viral-specific T cell response in LMP2 mutant mice
17. A tight cluster of five unrelated human genes on chromosome 16q22.1
18. Processing of some antigens by the standard proteasome but not by the immunoproteasome results in poor presentation by dendritic cells
19. Efficient generation of a hepatitis B virus cytotoxic T lymphocyte epitope requires the structural features of immunoproteasomes
20. MHC class I antigen processing of an adenovirus CTL epitope is linked to the levels of immunoproteasomes in infected cells
21. The proteasome: Paradigm of a self-compartmentalizing protease
22. Trimming of antigenic peptides in an early secretory compartment
23. Trimming of TAP-translocated peptides in the endoplasmic reticulum and in the cytosol during recycling
24. Processing of major histcompatibility class I-restricted antigens in the endoplasmic reticulum
25. Major differences in transporter associated with antigen presentation (TAP)-dependent translocation of MHC class I-presentable peptides and the effect of flanking sequences
26. TAP prefers to transport melanoma antigenic peptides which are longer than the optimal T cell epitope: Evidence for further processing in the ER
27. Cytotoxic T lymphocyte epitopes of HIV-1 Nef: Generation of multiple definitive major histocompatibility complex class I ligands by proteasomes
28. 26 S proteasome-mediated production of an authentic major histocompatibility class I-restricted epitope from an intact protein substrate
29. Human transporters associated with antigen processing (TAPs) select epitope precursor peptides for processing in the endoplasmic reticulum and presentation to T cells
30. The proteolytic fragments generated by vertebrate proteasomes: Structural relationships to major histocompatibility complex class I binding peptides
31. The making of the dominant MHC class I ligand SYFPEITHI
32. Proteolytic processing of ovalbumin and beta-galactosidase by the proteasome to a yield antigenic peptides
33. The interferon-gamma-inducible 11 S regulator (PA28) and the LMP2/LMP7 subunits govern the peptide production by the 20 S proteasome in vitro
34. Contribution of proteasome-mediated proteolysis to the hierarchy of epitopes presented by major histocompatibility complex class I molecules
35. Discrete proteolytic intermediates in the MHC class I antigen processing pathway and MHC I-dependent peptide trimming in the ER
36. Heat shock proteins transfer peptides during antigen processing and CTL priming
37. Rapid degradation of a large fraction of newly synthesized proteins by proteasomes
38. The major substrates for TAP in vivo are derived from newly synthesized proteins
39. Defective ribosomal products (DRiPs): A major source of antigenic peptides for MHC class I molecules?
40. Transporter associated with antigen processing