Accumulation of herpes simplex virus type 1 early and leaky-late proteins correlates with apoptosis prevention in infected human HEp-2 cells

Journal of Virology

Volumn 75, Issue 2, 2001, Pages 1013-1030

  Aubert, M ^a   Rice, S A ^a   Blaho, J A ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GENE PRODUCT; PHOSPHONOACETIC ACID; PROTEIN GC; PROTEIN GD; PROTEIN ICP22; PROTEIN ICP4; PROTEIN TK; PROTEIN VP16; UNCLASSIFIED DRUG; VIRUS DNA; VIRUS PROTEIN;

APOPTOSIS; ARTICLE; CELL STRAIN; CELL STRUCTURE; CHROMATIN CONDENSATION; CONTROLLED STUDY; DNA SYNTHESIS; HERPES SIMPLEX VIRUS 1; HERPES VIRUS INFECTION; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROCESSING; PROTEIN RNA BINDING; VIRUS RECOMBINANT; VIRUS REPLICATION;

ANIMALS; APOPTOSIS; CELL SIZE; CERCOPITHECUS AETHIOPS; DNA, VIRAL; EPITHELIAL CELLS; GENE EXPRESSION REGULATION, VIRAL; HERPESVIRUS 1, HUMAN; HUMANS; IMMEDIATE-EARLY PROTEINS; IMMUNOBLOTTING; MICROSCOPY, PHASE-CONTRAST; MUTATION; RECOMBINATION, GENETIC; TUMOR CELLS, CULTURED; VERO CELLS; VIRAL PROTEINS; VIRUS REPLICATION;

EID: 0035163815     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.75.2.1013-1030.2001     Document Type: Article

References (70)

1. The herpes simplex virus type 1 regulatory protein ICP27 is required for the prevention of apoptosis in infected human cells
2. Induction and prevention of apoptosis in human HEp-2 cells by herpes simplex virus type 1
3. Redistribution of microtubules and Golgi apparatus in herpes simplex virus-infected cells and their role in viral exocytosis
4. Characterization of the herpes simplex virion-associated factor responsible for the induction of alpha genes
5. Guanylylation and adenylylation of the alpha regulatory proteins of herpes simplex virus require a viral beta or gamma function
6. Tyrosine phosphorylation of the herpes simplex virus type 1 regulatory protein ICP22 and a cellular protein which shares antigenic determinants with ICP22
7. Herpes simplex virus DNA replication
8. Herpes simplex virus trans-regulatory protein ICP27 stabilizes and binds to 3′ ends of labile mRNA
9. Promoter-independent activation of heterologous virus gene expression by the herpes simplex virus immediate-early protein ICP27
10. Herpes simplex virus ICP27 induces cytoplasmic accumulation of unspliced polyadenylated α-globin pre-mRNA in infected HeLa cells
11. Proteases to die for
12. Temperature-sensitive mutants in herpes simplex virus type 1 ICP4 permissive for early gene expression
13. Isolation and characterization of deletion mutants of herpes simplex virus type 1 in the gene encoding immediate-early regulatory protein ICP4
14. Activation of immediate-early, early, and late promoters by temperature-sensitive and wild-type forms of herpes simplex virus type 1 protein ICP4
15. Processing of α-globin and ICP0 mRNA in cells infected with herpes simplex virus type 1 ICP27 mutants
16. Suppression of the synthesis of cellular macromolecules by herpes simplex virus
17. Bcl-2 blocks a caspase-dependent pathway of apoptosis activated by herpes simplex virus 1 infection in HEp-2 cells
18. Apoptotic pathways: The roads to ruin
19. Chromosomal aberrations induced by an animal virus
20. The regions important for the activator and repressor functions of herpes simplex virus type 1 alpha protein ICP27 map to the C-terminal half of the molecule
21. Herpes simplex virus inhibits host cell splicing, and regulatory protein ICP27 is required for this effect
22. Involvement of actin-containing microfilaments in HSV-induced cytopathology and the influence of inhibitors of glycosylation
23. Arginine-rich regions succeeding the nuclear localization region of the herpes simplex virus type 1 regulatory protein ICP27 are required for efficient nuclear localization and late gene expression
24. Regulation of herpesvirus macromolecular synthesis. I. Cascade regulation of the synthesis of three groups of viral proteins
25. Temperature-sensitive mutants of herpes simplex virus type 1 defective in lysis but not in transformation
26. Immediate early protein IE63 of herpes simplex virus type 1 binds RNA directly
27. A herpes simplex virus transcript abundant in latently infected neurons is dispensable for establishment of the latent state
28. Herpes simplex virus inhibits apoptosis through the action of two genes, Us5 and Us3
29. Definition and incidence of apoptosis: An historical perspective
30. Apoptosis: A basic biological phenomenon with wide-ranging implications in tissue kinetics
31. Induction of apoptosis by herpes simplex virus type 1
32. DFF, a heterodimeric protein that functions downstream of caspase-3 to trigger DNA fragmentation during apoptosis
33. Herpes simplex virus type 1 ICP27 deletion mutants exhibit altered patterns of transcription and are DNA deficient
34. Regulation of herpes simplex virus poly(A) site usage and the action of immediate-early protein IE63 in the early-late switch
35. Herpes simplex virus IE63 acts at the posttranscriptional level to stimulate viral mRNA 3′ processing
36. The repressing and enhancing functions of the herpes simplex virus regulatory protein ICP27 map to C-terminal regions and are required to modulate viral gene expression very early in infection
37. Identification of nuclear and nucleolar localization signals in the herpes simplex virus regulatory protein ICP27
38. The herpes simplex virus immediate-early protein ICP27 shuttles between nucleus and cytoplasm
39. The RGG box motif of the herpes simplex virus ICP27 protein mediates an RNA-binding activity and determines in vivo methylation
40. Caspases: Killer proteases
41. Virus-induced neuronal apoptosis blocked by the herpes simplex virus latency-associated transcript
42. A herpes simplex virus type 1 immediate-early gene product, IE63, regulates small nuclear ribonucleoprotein distribution
43. Herpes simplex virus type 1 immediate early protein IE63 shuttles between nuclear compartments and the cytoplasm
44. Herpes simplex virus type 1 protein IE63 affects the nuclear export of virus intron-containing transcripts
45. Modified VP22 localizes to the cell nucleus during synchronized herpes simplex virus type 1 infection
46. A generalized technique for deletion of specific genes in large genomes: Alpha gene 22 of herpes simplex virus 1 is not essential for growth
47. Herpes simplex virus 1 protein kinase is encoded by open reading frame US3 which is not essential for virus growth in cell culture
48. Isolation of a herpes simplex virus type 1 mutant with a deletion in the virion host shutoff gene and identification of multiple forms of the vhs (UL41) polypeptide
49. Genetic evidence for two distinct trans-activation functions of the herpes simplex virus alpha protein ICP27
50. Amino acid substitution mutations in the herpes simplex virus ICP27 protein define an essential gene regulation function
51. The acidic amino-terminal region of herpes simplex virus type 1 alpha protein ICP27 is required for an essential lytic function
52. Herpes simplex virus alpha protein ICP27 possesses separable positive and negative regulatory activities
53. Herpes simplex viruses and their replication
54. Herpes simplex virus type 1 ICP27 is an essential regulatory protein
55. Caspases: Intracellular signaling by proteolysis
56. Functional interactions between herpes simplex virus immediate-early proteins during infection: Gene expression as a consequence of ICP27 and different domains of ICP4
57. ICP27 mediates HSV RNA export by shuttling through a leucine-rich nuclear export signal and binding viral intronless RNAs through an RGG motif
58. The C-terminal repressor region of herpes simplex virus type 1 ICP27 is required for the redistribution of small nuclear ribonucleoprotein particles and splicing factor SC35; however, these alterations are not sufficient to inhibit host cell splicing
59. A herpesvirus regulatory protein appears to act post-transcriptionally by affecting mRNA processing
60. The herpes simplex virus type 1 alpha protein ICP27 can act as a trans-repressor or a trans-activator in combination with ICP4 and ICP0
61. Shuttling of the herpes simplex virus type 1 regulatory protein ICP27 between the nucleus and cytoplasm mediates the expression of late proteins
62. Herpesvirus mRNAs are sorted for export via Crm1-dependent and -independent pathways
63. Identification of an export control sequence and a requirement for the KH domains in ICP27 from herpes simplex virus type 1
64. CrmA-inhibitable cleavage of the 70-kDa protein component of the U1 small nuclear ribonucleoprotein during Fas- and tumor necrosis factor-induced apoptosis
65. CrmA, a poxvirus-encoded serpin, inhibits cytotoxic T-lymphocyte-mediated apoptosis
66. Herpes simplex ICP27 mutant viruses exhibit reduced expression of specific DNA replication genes
67. The herpes simplex virus immediate early protein ICP27 encodes a potential metal binding domain and binds zinc in vitro
68. Herpes simplex virus phosphoproteins. I. Phosphate cycles on and off some viral polypeptides and can alter their affinity for DNA
69. Cell death: The significance of apoptosis
70. Analysis of the phosphorylation sites of herpes simplex virus type 1 regulatory protein ICP27