Internalization of Bordetella pertussis adenylate cyclase-haemolysin into endocytic vesicles contributes to macrophage cytotoxicity

Cellular Microbiology

Volumn 3, Issue 11, 2001, Pages 721-730

  Khelef, Nadia ^a   Gounon, Pierre ^a   Guiso, Nicole ^a  

^a INSTITUT PASTEUR   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIN; ADENYLATE CYCLASE; CD107 ANTIGEN; CHOLESTEROL; HEMOLYSIN; LYSOSOME ASSOCIATED MEMBRANE PROTEIN 1; MEMBRANE PROTEIN; TRANSFERRIN; UNCLASSIFIED DRUG; VIRULENCE FACTOR;

ACTIN POLYMERIZATION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; BIOCHEMISTRY; BORDETELLA PERTUSSIS; CELL COMPARTMENTALIZATION; CELL DEATH; CELL MEMBRANE; CELL VACUOLE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOPLASM; CYTOTOXICITY; DEPLETION; ENDOCYTOSIS; ENDOSOME; EUKARYOTIC CELL; GOLGI COMPLEX; IMMUNOLOGY; INTERNALIZATION; INTOXICATION; LYSOSOME MEMBRANE; MACROPHAGE; MOUSE; NONHUMAN; NOSE INFECTION; PATHOLOGY; PINOCYTOSIS; PRIORITY JOURNAL; RAT;

ADENYLATE CYCLASE TOXIN; ANIMALS; APOPTOSIS; BORDETELLA PERTUSSIS; CELL LINE; FLUORESCENT ANTIBODY TECHNIQUE; HEMOLYSIN PROTEINS; MACROPHAGES; MICE; MICROSCOPY, IMMUNOELECTRON; TRANSPORT VESICLES; VIRULENCE FACTORS, BORDETELLA; WHOOPING COUGH;

EID: 0035163398     PISSN: 14625814     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1462-5822.2001.00151.x     Document Type: Article

References (32)

1. CyaC-mediated activation is important not only for toxic but also for protective activities of Bordetella pertussis adenylate cyclase-hemolysin
2. Protective effects of anti-Bordetella pertussis adenylate cyclase antibodies against lethal respiratory infection in the mouse
3. Phagocyte impotence caused by an invasive bacterial adenylate cyclase
4. Structural and functional relationships among the RTX toxin determinants of gram-negative bacteria
5. The calmodulin-sensitive adenylate cyclase of Bordetella pertussis: Cloning and expression in Escherichia coli
6. Inhibitors of receptor-mediated endocytosis block the entry of Bacillus anthracis adenylate cyclase toxin but not that of Bordetella pertussis adenylate cyclase toxin
7. + efflux, intoxication, and hemolysis by Bordetella pertussis AC toxin
8. Role of adenylate cyclase-hemolysin in alveolar macrophage apoptosis during Bordetella pertussis infection in vivo
9. Direct delivery of the Bordetella pertussis adenylate cyclase toxin to the MHC class I antigen presentation
10. 2 integrin (CD11b/CD18)
11. Translocation of Bacillus anthracis lethal and oedema factors across the endosome membranes
12. Modulation of leukotriene generation by pertussis toxin
13. Induction of macrophage apoptosis by Bordetella pertussis adenylate cyclase-hemolysin
14. Both adenylate cyclase and hemolytic activities are required by Bordetella pertussis to initiate infection
15. Bordetella pertussis induces apoptosis in macrophages: Role of adenylate cyclase-hemolysin
16. Characterization of murine lung inflammation after infection with parental Bordetella pertussis and mutants deficient in adhesins or toxins
17. The trans-Golgi network can be dissected structurally and functionally from the cisternae of the Golgi complex by brefeldin A
18. Toxin entry: Retrograde transport through the secretory pathway
19. In vitro inhibition of murine macrophage migration by Bordetella pertussis lymphocytosis-promoting factor
20. Protein toxin and membrane transport
21. Inhibition of coated pits formation in Hep-2 cells blocks the cytotoxicity of diphtheria toxin but not of ricin toxin
22. Adaptive responses of human monocytes infected by Bordetella pertussis: The role of adenylate cyclase hemolysin
23. Constitutive macropinocytosis allows TAP-dependent major histocompatibility complex class I presentation of exogenous soluble antigen by bone marrow-derived dendritic cells
24. Inhibition of monocyte oxidative responses by Bordetella pertussis adenylate cyclase toxin
25. CD14-dependent endotoxin internalization via a macropinocytic pathway
26. Immunogold labeling of ultrathin cryosections: Applications in immunology
27. Extraction of cholesterol with methyl-beta-cyclodextrin perturbs formation of clathrin-coated endocytic vesicles
28. Distinct steps in the penetration of adenylate cyclase toxin of Bordetella pertussis into sheep erythrocytes
29. Entry of ricin and Shiga toxin into cells: Molecular mechanisms and medical perspectives
30. Involvement of cellular caveolae in bacterial entry into mast cells
31. Receptor mediated and fluid phase pathways for internalization of the ER Hsp90 chaperone GRP94 in murine macrophages
32. Pertussis toxin and extracytoplasmic adenylate cyclase as virulence factors of Bordetella pertussis