Expression of P-glycoprotein in inner ear capillary endothelial cells of the guinea pig with special reference to blood-inner ear barrier

Brain Research

Volumn 767, Issue 2, 1997, Pages 388-392

  Saito, Takehisa ^a   Zhang, Zhi Jian ^a   Tsuzuki, Hideaki ^a   Ohtsubo, Toshio ^a   Yamada, Takechiyo ^a   Yamamoto, Takehito ^a   Saito, Hitoshi ^a  

^a UNIVERSITY OF FUKUI   (Japan)

Author keywords

Blood inner ear barrier; Blood brain barrier; Cochlea; Immunohistochemistry; Inner ear; P glycoprotein; Vestibule; Western blotting

Indexed keywords

GLYCOPROTEIN P;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; CAPILLARY ENDOTHELIUM; COCHLEA; CONTROLLED STUDY; ENDOTHELIUM CELL; GUINEA PIG; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; INNER EAR; NONHUMAN; PRIORITY JOURNAL; VESTIBULE;

ANIMALS; CAPILLARY PERMEABILITY; EAR, INNER; ENDOTHELIUM, VASCULAR; GUINEA PIGS; IMMUNOHISTOCHEMISTRY; P-GLYCOPROTEIN;

EID: 0343811722     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(97)00821-4     Document Type: Article

References (18)

1. Bradley G., Georges E., Ling V. Sex-dependent and independent expression of the P-glycoprotein isoforms in Chinese hamster. J. Cell. Physiol. 145:1990;398-408.
2. Cordon-Cardo C., O'Brien J.P., Casals D., Rottman-Grauer L., Biedler J.L., Melamed M.R., Bertino J.R. Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain sites. Proc. Natl. Acad. Sci. USA. 86:1989;695-698.
3. Dulon D., Aran J.-M., Zajic G., Schacht J. Comparative uptake of gentamicin, netilmicin, and amikacin in the guinea pig cochlea and vestibule. Antimicrob. Agents Chemother. 30:1986;96-100.
4. Goldstein G.W., Betz A.L. The blood-brain barrier. Sci. Am. 255:1986;70-79.
5. Goldstein L.J., Galski H., Fojo A., Willingham M., Lai S.-L., Gazdar A., Pirker R., Green A., Crist W., Brodeur G.M., Lieber M., Cossman J., Gottesman M.M., Pastan I. Expression of a multidrug resistance gene in human cancers. J. Natl. Cancer Inst. 81:1989;116-124.
6. Hawkins E. Ototoxic mechanisms, a working hypothesis. Audiology. 12:1973;383-393.
7. Jahnke K. The blood-perilymph barrier. Arch. Otorhinolaryngol. 228:1980;29-34.
8. Juhn S.K., Rybak L.P., Prado S. Nature of blood-labyrinth barrier in experimental conditions. Ann. Otol. 90:1981;135-141.
9. Juhn S.K. Barrier system in the inner ear. Acta Otolaryngol. Suppl. 1988;79-83.
10. Jung W.K., Gattaz G., Schön F.J. Kinetic experiments with radionuclides concerning the perilymph-blood barrier in a guinea pig model. Arch. Otorhinolaryngol. 246:1989;11-19.
11. Mrsulja B.B., Mrsulja B.J., Fujimoto T., Klatzo I., Spatz M. Isolation of brain capillaries: a simplified technique. Brain Res. 110:1976;361-365.
12. Saito T., Manabe Y., Saito H. Ototoxicity of the new platinum anticancer agent TRK-710 in comparison with cisplatin. ORL. 57:1995;250-255.
13. Sakagami M., Matsunaga T., Hashimito P.H. Fine structure and permeability of capillaries in the stria vascularis and spiral ligament of the inner ear of the guinea pig. Cell Tissue Res. 226:1982;511-522.
14. Sakagami M., Sano M., Harada T., Kubo T., Matsunaga T., Sakai S. Morphological study of blood-labyrinth barrier in the vestibular organs under normal and experimental acute hypertensive and acute hypotensive conditions. Acta Otolaryngol. 101:1986;165-171.
15. Shinkel A.H., Smit J.J.M., van Tellingen O., Beijnen J.H., Wagenaar E., van Deemter L., Mol C.A.A.M., van der Valk M.A., Robanus-Maandag E.C., te Riele H.P.J., Berns A.J.M., Borst P. Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs. Cell. 77:1994;491-502.
16. Sugawara I., Hamada H., Tsuruo T., Mori S. Specialized localization of P-glycoprotein recognized by MRK 16 monoclonal antibody in endothelial cells of the brain and spinal cord. Jpn. J. Cancer Res. 81:1990;727-730.
17. Tatsuta T., Naito M., Oh-hara T., Sugawara I., Tsuruo T. Functional involvement of P-glycoprotein in blood-brain barrier. J. Biol. Chem. 267:1992;20383-20391.
18. Thiebaut F., Tsuruo T., Hamada H., Gottesman M.M., Pastan Ira, Willingham M.C. Immunohistochemical localization in normal tissues of different epitopes in the multidrug transport protein P170: evidence for localization in brain capillaries and crossreactivity of one antibody with a muscle protein. J. Histochem. Cytochem. 37:1989;159-164.