Pesticide exposure: Differential risk for neurotoxic outcomes due to enzyme polymorphisms

Clinics in Occupational and Environmental Medicine

Volumn 1, Issue 3, 2001, Pages 511-523

  Costa, L G ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ENVIRONMENTAL CHEMICAL; FUNGICIDE; HERBICIDE; INSECTICIDE; ORGANOPHOSPHATE INSECTICIDE; PESTICIDE;

ARTICLE; BIOTRANSFORMATION; CELL REGENERATION; CONTROLLED STUDY; ENVIRONMENTAL EXPOSURE; ENVIRONMENTAL FACTOR; ENZYME POLYMORPHISM; GENETIC POLYMORPHISM; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; GENETICS; HEALTH HAZARD; HEREDITY; HUMAN; NEUROTOXICITY; PHARMACOGENETICS; PHENOTYPE;

EID: 0035160653     PISSN: 15260046     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (58)

1. Enzyme Inhibitors as Substrates
2. Does paraoxonase play a role in susceptibility to cardiovascular disease?
3. Mutation at codon 322 in the human acetylcholinesterase (ACHE) gene accounts for YT blood group polymorphism
4. A-esterase activities in relation to the differential toxicity of pirimiphos-methyl to birds and mammals
5. Protection by butyrylcholinesteraase against organophosphorus poisoning in nonhuman primates
6. Polymorphisms in the human paraoxonase (PON1) promoter
7. Analysis of paraoxonase (PON1) L55M status requires both genotype and phenotype
8. Biotransformation of parathion in human liver: Participation of CYP3A4 and its inactivation during microsomal parathion oxidation
9. Genetic polymorphisms in Parkinson's disease
10. Serum paraoxonase and its influence on paraoxon and chlorpyrifos-oxon toxicity in rats
11. Ecogenetics: Determining susceptibility to chemical-induced diseases
12. Species differences in serum paraoxonase correlate with sensitivity to paraoxon toxicity
13. The emerging field of ecogenetics
14. The effect of the human serum paraoxonase polymorphism is reversed with diazoxon, soman and sarin
15. Concise review of the glutathione S-transferases and their significance to toxicology
16. Genetic susceptibility
17. Biotransformation enzyme polymorphism and pesticide susceptibility
18. The human serum paraoxonase/arylesterase polymorphism
19. Butyrylcholinesterase variants (BCHE and CHE1 loci) associated with erythrocyte acetylcholinesterase inhibition in farmers exposed to pesticides
20. Human and rabbit paraoxonase: Purification, cloning, sequencing, mapping and role of polymorphism in organophosphate detoxication
21. The human serum paraoxonase-polymorphism and specificity
22. High susceptibility to lung cancer analyzed in terms of combined genotypes of P4501A1 and Mu-class glutathione S-transferase gene
23. Combination of susceptible genotypes and individual responses to toxicants
24. The molecular basis of the human serum paraoxonase activity polymorphism
25. Evidence for association between paraoxonase gene polymorphisms and atherosclerotic diseases
26. Familial reduction in red-cell cholinesterase
27. "It's the genes, stupid." Molecular bases and clinical consequences of genetic cytochrome P450 2D6 polymorphism
28. P450 enzyme CYP2B catalyzes the detoxification of diisopropyl fluorophosphate
29. Promoter polymorphisms of human paraoxonase PON1 gene and serum paraoxonase activities and concentrations
30. Two alleles of the human paraoxonase gene produce different amounts of mRNA. An explanation for differences in serum concentrations of paraoxonase associated with the (Leu-Met 54) polymorphism
31. Abundant tissue butyrylcholinesterase and its possible function in the acetylcholinesterase knockout mouse
32. Paraoxonase (PON1) gene in mice: Sequencing, Chromosomal localization and developmental expansion
33. Catalytic efficiency determines the in vivo efficacy of PON1 for detoxifying organophosphates
34. Serum paraoxonase status: A major factor in determining resistance to organophosphates
35. Complete aminoacid sequence of human serum cholinesterase
36. Pesticide and susceptible populations: People with butyrylcholinesterase genetic variants may be at risk
37. Inhibition of lymphocytic neuropathy target esterase predicts the development of organophosphate-induced delayed polyneuropathy
38. Organophosphorus compounds
39. The pathogenesis of organophosphate delayed polyneuropathy
40. Human serum paraoxonase
41. The role of A-esterase in the acute toxicity of paraoxon, TEPP and parathion
42. Molecular mechanisms of genetic polymorphisms of drug metabolism
43. Pharmacogenetics and ecogenetics in 1991
44. Plasma paraoxonase polymorphism: A new enzyme assay, population, family, biochemical, and linkage studies
45. Environment and cancer: Who are susceptible?
46. Organophosphate detoxication potential of various rat tissues via A-esterase and aliesterase activities
47. Determination of paraoxonase (PON1) status requires more than genotyping
48. Acute polyneuropathy after poisoning by a new organophosphate insecticide
49. Mice lacking serum paraoxonase are susceptible to organophosphate toxicity and atherosclerosis
50. Interindividual variations in human liver cytochrome P450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemical studies with liver microsomes of 30 Japanese and 30 Caucasians
51. Hereditary deficiency of erythrocyte acetylcholinesterase
52. A polymorphism in the δ-aminolevulimic acid dehydratase gene may modify the pharmacokinetics and toxicity of lead
53. Glutathione S-transferase: Genetics and role in toxicology
54. Factors involved in the differential acute toxicity of the insecticides chlorpyrifos and methyl chlorpyrifos in mice
55. Role of glutathione in the mammalian detoxication of organophosphorus insecticides
56. Genetic polymorphisms of human N-acetyltransferase, cytochrome P450, glutathione S-transferase and epoxide hydrolase enzyme. Relevance to xenobiotics metabolism and toxicity
57. Postnatal developmental delay and supersensitivity to organophosphate in gene-targeted mice lacking acetylcholinesterase
58. Knockout of one acetylcholinesterase allele in the mouse