Functional cooperation of epstein-barr virus nuclear antigen 2 and the survival motor neuron protein in transactivation of the viral LMP1 promoter

Journal of Virology

Volumn 75, Issue 23, 2001, Pages 11781-11790

  Voss, M D ^a   Hille, A ^a   Barth, S ^a   Spurk, A ^a   Hennrich, F ^a   Holzer, D ^a   Mueller Lantzsch, N ^a   Kremmer, E ^a   Grasser F A ^a  

^a SAARLAND UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CELL NUCLEUS ANTIGEN; DEAD BOX PROTEIN; NUCLEAR ANTIGEN 2; PROTEIN; RNA POLYMERASE II; SURVIVAL MOTOR NEURON PROTEIN; UNCLASSIFIED DRUG; VIRUS ANTIGEN;

ARTICLE; B LYMPHOCYTE; CARBOXY TERMINAL SEQUENCE; CELLULAR DISTRIBUTION; COMPLEX FORMATION; EPSTEIN BARR VIRUS; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN PROTEIN INTERACTION; SPLICEOSOME; TRANSACTIVATION;

BASE SEQUENCE; CELL LINE; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; DNA PRIMERS; EPSTEIN-BARR VIRUS NUCLEAR ANTIGENS; FLUORESCENT ANTIBODY TECHNIQUE; HUMANS; NERVE TISSUE PROTEINS; PROMOTER REGIONS (GENETICS); RNA-BINDING PROTEINS; TRANS-ACTIVATION (GENETICS); VIRAL MATRIX PROTEINS; VIRAL PROTEINS;

EID: 0035158971     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.75.23.11781-11790.2001     Document Type: Article

References (46)

1. Direct interaction of SMN with dp103, a putative RNA helicase: A role for SMN in transcription regulation?
2. Gemin3: A novel DEAD box protein that interacts with SMN, the spinal muscular atrophy gene product, and is a component of gems
3. Gemin4. A novel component of the SMN complex that is found in both gems and nucleoli
4. Mutation analysis of the SMN gene in undeleted SMA patients
5. Epstein-Barr virus nuclear protein 2 mutations define essential domains for transformation and transactivation
6. A potential NES of the Epstein-Barr virus nuclear antigen 1 (EBNA1) does not confer shuttling
7. The SMN-SIP1 complex has an essential role in spliceosomal snRNP biogenesis
8. Assembly of the nuclear processing and transcription machinery: Cajal bodies (coiled bodies) and transcriptosomes
9. Detection of proteins associated with the Epstein-Barr virus nuclear antigen 2: EBNA2A binds to histone H1 and unknown cellular proteins of 130, 110, 105, and 95 kDa
10. Characterization of DP103, a novel DEAD box protein that binds to the Epstein-Barr virus nuclear proteins EBNA2 and EBNA3C
11. The Schizosaccharomyces pombe protein Yab8p and a novel factor, Yip1p, share structural and functional similarity with the spinal muscular atrophy-associated proteins SMN and SIP1
12. Mediation of Epstein-Barr virus EBNA2 transactivation by recombination signal-binding protein Jκ
13. Synergistic anti-apoptotic activity between Bcl-2 and SMN implicated in spinal muscular atrophy
14. Three unrelated viral transforming proteins (vIRF, EBNA2, and E1A) induce the MYC oncogene through the interferon-responsive PRF element by using different transcription coadaptors
15. Epstein-Barr virus and its replication
16. Rat monoclonal antibodies differentiating between the Epstein-Barr virus nuclear antigens 2A (EBNA2A) and 2B (EBNA2B)
17. The Spi-1/ PU.1 and Spi-B ets family transcription factors and the recombination signal binding protein RBP-Jκ interact with an Epstein-Barr virus nuclear antigen 2 responsive cis-element
18. Identification and characterization of an Epstein-Barr virus nuclear antigen 2-responsive cis element in the bidirectional promoter region of latent membrane protein and terminal protein 2 genes
19. Identification and characterization of a spinal muscular atrophy-determining gene
20. Contribution of conserved amino acids in mediating the interaction between EBNA2 and CBF1/RBPJκ
21. A novel nuclear structure containing the survival of motor neurons protein
22. SMN oligomerization defect correlates with spinal muscular atrophy severity
23. Epstein-Barr virus-encoded protein found in plasma membranes of transformed cells
24. Identification of proximal spinal muscular atrophy carriers and patients by analysis of SMNT and SMNC gene copy number
25. Characterization of a nuclear 20S complex containing the survival of motor neurons (SMN) protein and a specific subset of spliceosomal Sm proteins
26. Analysis of mutations in the tudor domain of the survival motor neuron protein SMN
27. The DEAD box protein DP103 is a regulator of steroidogenic factor-1
28. Characterization of the Schizosaccharomyces pombe orthologue of the human survival motor neuron (SMN) protein
29. Mutational analysis of a DEAD box RNA helicase: The mammalian translation initiation factor eIF-4A
30. A functional interaction between the survival motor neuron complex and RNA polymerase II
31. A novel function for SMN, the spinal muscular atrophy disease gene product, in pre-mRNA splicing
32. Protein-protein interactions: Methods for detection and analysis
33. Epstein-Barr virus
34. Mutational analysis of the Epstein-Barr virus nuclear antigen 2 by far-Western blotting and DNA-binding studies
35. Inactivation of the survival motor neuron gene, a candidate gene for human spinal muscular atrophy, leads to massive cell death in early mouse embryos
36. Identification of survival motor neuron as a transcriptional activator-binding protein
37. Both Epstein-Barr viral nuclear antigen 2 (EBNA2) and activated Notch1 transactivate genes by interacting with the cellular protein RBP-Jκ
38. The 62- and 80-kDa subunits of transcription factor IIH mediate the interaction with Epstein-Barr virus nuclear protein 2
39. The Epstein-Barr virus nuclear protein 2 acidic domain can interact with TFIIB, TAF40, and RPAT0 but not with TATA-binding protein
40. The EBNA-2 arginine-glycine domain is critical but not essential for B-lymphocyte growth transformation; the rest of region 3 lacks essential interactive domains
41. Epstein-Barr virus nuclear protein 2 interacts with p300, CBP, and PCAF histone acetyltransferases in activation of the LMP1 promoter
42. Promotor-specific targeting of human SWi-SNF complex by Epstein-Barr virus nuclear protein 2
43. Epstein-Barr virus nuclear protein 2 (EBNA2) binds to a component of the human SNF-SWI complex, hSNF5/Ini1
44. Epstein-Barr virus BamHI-A rightward transcript-encoded RPMS protein interacts with the CBF1-associated corepressor CIR to negatively regulate the activity of EBNA2 and Notch1C
45. The Epstein-Barr virus nuclear antigen 2 interacts with an EBNA2 responsive cis-element of the terminal protein 1 gene promoter
46. Epstein-Barr virus nuclear antigen 2 exerts its transactivating function through interaction with recombination signal binding protein RBP-Jκ, the homologue of Drosophila Suppressor of Hairless