Homotypic fusion of immature secretory granules during maturation requires syntaxin 6

Molecular Biology of the Cell

Volumn 12, Issue 6, 2001, Pages 1699-1709

  Wendler, F ^a   Page, L ^a   Urbe S ^a   Tooze, S A ^a  

^a IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

HORMONE; HYBRID PROTEIN; NEUROPEPTIDE; SNARE PROTEIN; SYNTAXIN; SYNTAXIN 6; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL FREE SYSTEM; CELL STRUCTURE; CONTROLLED STUDY; MEMBRANE FUSION; NEUROSECRETORY CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; RAT; SECRETORY GRANULE; STRUCTURE ANALYSIS;

ANIMALIA;

EID: 0035158011     PISSN: 10591524     EISSN: None     Source Type: Journal    
DOI: 10.1091/mbc.12.6.1699     Document Type: Article

References (65)

1. Seven novel mammalian SNARE proteins localize to distinct membrane compartments
2. Sorting and storage during secretory granule biogenesis: Looking backward and looking forward
3. Direct and GTP-dependent interaction of ADP-ribosylation factor 1 with clathrin adaptor protein AP-1 on immature secretory granules
4. 2+-activated exocytosis
5. Syntaxin: A synaptic protein implicated in docking of synaptic vesices at presynaptic active zones
6. The syntaxin family of vesicular transport receptors
7. Proteolysis of SNAP-25 by types E and A botulinal neurotoxins
8. Syntaxin 6 functions in trans Golgi network vesicle trafficking
9. A new syntaxin family member implicated in targeting of intracellular transport vesicles
10. The Rab5 effector EEA1 is a core component of endosome docking
11. Membrane transport: Deciphering fusion
12. In vitro reactions of vacuole inheritance in Saccharomyces cerevisiae
13. Characterization of the endopeptidase PC2 activity towards SgII in stably transfected PC12 cells
14. The AP-1 adaptor complex binds to immature secretory granules from PC12 cells, and is regulated by ADP-ribosylation factor
15. Differential distribution of mannose-6-phosphate receptors and furin in immature secretory granules
16. Interaction of furin in immature secretory granules from neuroendocrine cells with the AP-1 adaptor complex is modulated by casein kinase II phosphorylation
17. Biogenesis of regulated exocytotic carriers in neuroendocrine cells
18. Functional architecture of an intracellular membrane t-SNARE
19. Distinct cellular locations of the syntaxin family of proteins in rat pancreatic acinar cells
20. The C terminus of SNAP25 is essential for Ca2+-dependent binding of synaptotagmin to SNARE complexes
21. Botulinum neurotoxin light chains inhibit both Ca2+-induced and GTP analogue induced catecholamine release from permeabilized adrenal chromaffin cells
22. Reconstitution of vesicle fusions occurring in endocytosis with a cell-free system
23. Adrenal chromaffin cells contain functionally different SNAP-25 monomers and SNAP-25/syntaxin heterodimers
24. Membrane fusion and exocytosis
25. Mannose 6-phosphate receptors are sorted from immature secretory granules via adaptor protein AP-1, clathrin, and syntaxin 6-positive vesicles
26. Differential sorting of lysosomal enzymes out of the regulated secretory pathway in pancreatic β-cells
27. Transient expression of botulinum neurotoxin C1 light chain differentially inhibits calcium and glucose induced insulin secretion in clonal beta-cells
28. SNARE-mediated retrograde traffic from the Golgi complex to the endoplasmic reticulum
29. Involvement of SNAP-23 and syntaxin 6 in human neutrophil exocytosis
30. Intracellular membrane fusion: SNAREs only?
31. Docking of yeast vacuoles is catalyzed by the ras-like GTPase Ypt7p after symmetric priming by Sec18p (NSF)
32. Oligomeric complexes link Rab5 effectors with NSF and drive membrane fusion via interactions between EEA1 and syntaxin 13
33. Compartmental specificity of cellular membrane fusion encoded in SNARE proteins
34. SNAP-25 and synaptotagmin involvement in the final Ca(2+)-dependent triggering of neurotransmitter exocytosis
35. Involvement of the endosomal autoantigen EEA1 in homotypic fusion of early endosomes
36. Homotypic vacuolar fusion mediated by t-and v-SNAREs
37. Rabenosyn-5, a NOVEL Rah5 effector, is complexed with hVPS45 and recruited to endosomes through a FYVE finger domain
38. The identification of a novel synaptosomal-associated protein SNAP-25, differentially expressed by neuronal subpopulations
39. Organelle membrane fusion: A novel function for the syntaxin homolog Ufe1p in ER membrane fusion
40. Syntaxin 5 is a common component of the NSF- and p97-mediated reassembly pathways of Golgi cisternae from mitotic Golgi fragments in vitro
41. Docking and fusion in neurosecretion
42. Role of p97 and syntaxin 5 in the assembly of transitional endoplasmic reticulum
43. The specifics of membrane fusion
44. Neurotoxins affecting neuroexocytosis
45. SNAP receptors implicated in vesicle targeting and fusion
46. Vesicle-associated membrane protein 4 is implicated in trans-Golgi network vesicle trafficking
47. Crystal structure of a SNARE complex involved in synaptic exocytosis at 2.4 A resolution
48. Syntaxin 1 (HPC-1) is associated with chromaffin granules
49. Structures of yeast vesicle trafficking proteins
50. Biogenesis of secretory granules in the trans-Golgi network of neuroendocrine and endocrine cells
51. Characterization of the immature secretory granule, an intermediate in granule biogenesis
52. Antibodies to secretogranin II reveal potential processing sites
53. Protein traffic from the secretory pathway to the endosomal system in pancreatic beta-cells
54. A vacuolar v-t-SNARE complex, the predominant form in vivo and on isolated vacuoles, is disassembled and activated for docking and fusion
55. Defining the functions of trans-SNARE pairs
56. pH-dependent processing of secretogranin II by the endopeptidase PC2 in isolated immature secretory granules
57. Homotypic fusion of immature secretory granules during maturation in a cell-free assay
58. The t-SNARE syntaxin 1 and SNAP25 are present on organelles that participate in synaptic vesicle recycling
59. Molecular cloning of phogrin, a protein-tyrosine phosphatase homologue localized to insulin secretory granule membranes
60. Functional cooperation of two independent targeting domains in syntaxin 6 is required for its efficient localization in the trans-Golgi network of 3T3L1 adipocytes
61. SNAREpins: Minimal machinery for membrane fusion
62. SNAP family of NSF attachment proteins includes a brain-specific isoform
63. Yeast homotypic vacuole fusion: A window on organelle trafficking mechanisms
64. GS32, a novel Golgi SNARE of 32 kDa, interacts preferentially with syntaxin 6
65. LMA1 binds to vacuoles at Sec18p (NSF), transfers upon ATP hydrolysis to a t-SNARE (Vam3p) complex, and is released during fusion