Quantitative determination of BMS-186716, a thiol compound, in rat plasma by high-performance liquid chromatography-positive ion electrospray mass spectrometry after hydrolysis of the methyl acrylate adduct by the native esterases

Journal of Chromatography B: Biomedical Applications

Volumn 698, Issue 1-2, 1997, Pages 123-132

  Jemal, Mohammed ^a   Hawthorne, Dara J ^a  

^a BRISTOL MYERS SQUIBB   (United States)

Author keywords

BMS 186716; Methyl acrylase

Indexed keywords

METALLOPROTEINASE INHIBITOR; OMAPATRILAT; THIOL DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DERIVATIZATION; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG STABILITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE ASSAY; RAT; TECHNIQUE;

ACRYLATES; ANIMALS; CARDIOVASCULAR AGENTS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; ESTERASES; HYDROLYSIS; MASS SPECTROMETRY; PYRIDINES; RATS; REFERENCE STANDARDS; SENSITIVITY AND SPECIFICITY; THIAZEPINES;

EID: 0030812971     PISSN: 15726495     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-4347(97)00292-2     Document Type: Article

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