Unwinding the 'Gordian knot' of helicase action

Trends in Biochemical Sciences

Volumn 26, Issue 1, 2001, Pages 47-54

  Soultanas, Panos ^a   Wigley, Dale B ^b  

^a UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^b IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; DNA; HELICASE; MAGNESIUM ION;

AMINO ACID SEQUENCE; CATALYSIS; CHROMOSOME TRANSLOCATION; CROSS LINKING; CRYSTAL STRUCTURE; DNA STRAND; ENZYME ACTIVITY; ENZYME MECHANISM; ENZYME STABILITY; ENZYME STRUCTURE; ENZYME SUBUNIT; NONHUMAN; NUCLEIC ACID METABOLISM; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEGRADATION; REVIEW;

ADENOSINE TRIPHOSPHATE; AMINO ACID MOTIFS; BACTERIAL PROTEINS; DNA HELICASES; NUCLEIC ACID HETERODUPLEXES; RNA HELICASES;

EID: 0035150184     PISSN: 09680004     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0004(00)01734-5     Document Type: Review

References (37)

1. Enzymatic unwinding of DNA: Purification and characterization of a DNA-dependent ATPase from Escherichia coli
2. Helicases: Amino acid sequence comparisons and structure-function relationships
3. Distantly related sequences in the α- and β-subunits of ATP synthase, myosin, kinases and other ATP-requiring enzymes and a common nucleotide binding fold
4. DNA helicases in inherited human disorders
5. DNA Helicases: 'Inching forward'
6. Mechanisms of helicase-catalysed DNA unwinding
7. Enzyme-catalysed DNA unwinding: Studies on Escherichia coli Rep protein
8. Allosteric effects of nucleotide cofactors on Escherichia coli Rep helicase-DNA binding
9. Crystal structures of complexes of PcrA DNA helicase with a DNA substrate indicate an inchworm mechanism
10. Demonstration of unidirectional single-stranded DNA translocation by PcrA helicase: Measurement of step size and translocation speed
11. Product release is the major contributor to Kcat for the hepatitis C virus helicase-catalyzed strand separation of short duplex DNA
12. DNA helicases displace streptavidin from biotin-labelled oligonucleotides
13. Endonuclease (R) subunits of type-I and type-III restriction-modification enzymes contain a helicase-like domain
14. Restriction enzymes in cells, not eppendorfs
15. The DNA translocation and ATPase activities of restriction-deficient mutants of EcoKI
16. Crystal structure of UvrB, a DNA helicase adapted for nucleotide excision repair
17. Reverse gyrase: A helicase-like domain and a type I topoisomerase in the same polypeptide
18. A two-subunit type I DNA topoisomerase (reverse gyrase) from an extreme hyperthermophile
19. RecQ helicase and topoisomerase III comprise a novel DNA strand passage function: A conserved mechanism for control of DNA recombination
20. Sgs1: A eukaryotic homolog of E. coli RecQ that interacts with topoisomerase II in vivo and is required for faithful chromosome segregation
21. Werner syndrome helicase contains a 5′-3′ exonuclease activity that digests DNA and RNA strands in DNA/DNA and RNA/DNA duplexes dependent on unwinding
22. Characterisation of Werner syndrome protein DNA helicase activity: Directionality, substrate dependence and stimulation by replication protein A
23. Uncoupling DNA translocation and helicase activity in PcrA: Direct evidence for an active mechanism
24. Crystal structure of the helicase domain from the replicative helicase-primase of bacteriophage T7
25. Crystal structure of T7 gene 4 ring helicase indicates a mechanism for sequential hydrolysis of nucleotides
26. Helicases as nucleic acid unwinding machines
27. Interactions of bacteriophage T7 DNA primase/helicase protein with single-stranded and double-stranded DNAs
28. Binding of Escherichia coli primary replicative helicase DnaB protein to single-stranded DNA. Long range allosteric conformational changes within the protein hexamer
29. DNA is bound within the central hole to one or two of the six subunits of the T7 DNA helicase
30. Helicases: A unifying structural theme?
31. 1-ATPase from bovine heart mitochondria
32. The binding change mechanism for ATP synthase some probabilities and possibilities
33. 1-ATPase
34. Escherichia coli transcription termination protein rho has three hydrolytic sites for ATP
35. Transcription termination factor Rho contains three noncatalytic nucleotide binding sites
36. Cooperative interactions of nucleotide ligands are linked to oligomerisation and DNA binding in bacteriophage T7 gene 4 helicases
37. Step size measurements on the translocation mechanism of the RecBC DNA helicase