Contribution of the active metabolite, norcocaine, to cocaine's effects after intravenous and oral administration in rats: Pharmacodynamics

Psychopharmacology

Volumn 153, Issue 3, 2001, Pages 341-352

  Wang, Q ^a   Simpao, A ^a   Sun, L ^a   Falk, J L ^a   Lau, C E ^a  

^a RUTGERS UNIVERSITY   (United States)

Author keywords

Cocaine; Norcocaine; Pharmacodynamic; Pharmacokinetic; Routes of administration

Indexed keywords

COCAINE; DRUG METABOLITE; NORCOCAINE;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG BIOAVAILABILITY; DRUG EFFECT; DRUG METABOLISM; DRUG POTENCY; DRUG TOLERANCE; MALE; NONHUMAN; PHARMACODYNAMICS; PRIORITY JOURNAL; RAT; REINFORCEMENT; TASK PERFORMANCE;

ADMINISTRATION, ORAL; ANIMALS; COCAINE; DOPAMINE UPTAKE INHIBITORS; DOSE-RESPONSE RELATIONSHIP, DRUG; MALE; MOTOR ACTIVITY; RATS; RATS, SPRAGUE-DAWLEY; REACTION TIME; REINFORCEMENT (PSYCHOLOGY);

EID: 0035142989     PISSN: 00333158     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002130000568     Document Type: Article

References (30)

1. Comparative behavioral profile of cocaine and norcocaine in rats and monkeys
2. Rate of change of blood concentrations is a major determinant of the pharmacodynamics of midazolam in rats
3. A user's guide to ALLFIT. Simultaneous fitting of families of sigmoidal dose response curves using the four-parameter logistic equation
4. A comparison of cocaine and its metabolite nococaine: Effects on lococomotor activity
5. Low-dose oral cocaine in humans: Acquisition of discrimination and time-course of effects
6. A pharmacologically active metabolite of cocaine found in brain
7. Metabolism of cocaine in man
8. Cocaine and metabolite concentrations in plasma during repeated oral administration: Development of a human laboratory model of chronic cocaine use
9. Local anesthetic potency of norcocaine, a metabolite of cocaine
10. Tolerance to oral and IP caffeine: Locomotor activity and pharmacokinetics
11. Pharmacokinetic-pharmacodynamic modeling of stimulatory and sedative effects of alprazolam: Timing performance deficits
12. Alprazolam, caffeine and their interaction: Relating DRL performance to pharmacokinetics
13. Pharmacokinetics and bioavailability of midazolam after intravenous, subcutaneous, intraperitoneal and oral administration under a chronic food-limited regimen: Relating DRL performance to pharmacokinetics
14. Differential reinforcement of low rate performance, pharmacokinetics and pharmacokinetic-pharmacodynamic modeling: Independent interaction of alprazolam and caffeine
15. Pharmacokinetic-pharmacodynamic modeling of the psychomotor stimulant effect of cocaine after intravenous administration: Timing performance deficits
16. Pharmacokinetic determinants of cocaine's differential effects on locomotor and operant behavior
17. Oral cocaine pharmacokinetics and pharmacodynamics in a cumulativedose regimen: Pharmacokinetic-pharmacodynamic modeling of concurrent operant and spontaneous behavior within an operant context
18. Cocaine pharmacodynamics after intravenous and oral administration in rats: Relation to pharmacokinetics
19. Within-subject variability in cocaine pharmacokinetics and pharmacodynamics after intraperitoneal in comparison with intravenous cocaine administration
20. Lethal toxicity from equimolar infusions of cocaine and cocaine metabolites in conscious and anesthetized rats
21. Generalization of norcocaine to the discriminative stimulus properties of cocaine
22. 3H] cocaine in rat brain
23. 2-epimerization of cocaine on its pharmacokinetics in the rat
24. Locomotor effects of cocaine, cocaine congeners, and local anesthetics in mice
25. Intravenous self-administration of cocaine and norcocaine by dogs
26. Acute physiological and behavioral effects of oral cocaine in humans: A dose-response analysis
27. Self-administration of cocaine derivatives by squirrel monkeys
28. Effects of norcocaine and some norcocaine derivatives on schedule-controlled behavior of pigeons and squirrel monkeys
29. Intravenous and oral clozapine pharmacokinetics, pharmacodynamics, and concentration-effect relations: Acute tolerance
30. The influence of drug input rate on the development of tolerance to frusemide