Influence of coadministration of fluoxetine on cisapride pharmacokinetics and QTc intervals in healthy volunteers

Pharmacotherapy

Volumn 21, Issue 2, 2001, Pages 149-157

  Zhao, Q ^a   Wojcik, M A ^a   Parier, J L ^a   Pesco Koplowitz, L ^a  

^a JANSSEN RESEARCH AND DEVELOPMENT   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CISAPRIDE; FLUOXETINE;

ADULT; ARTICLE; CLINICAL TRIAL; DIARRHEA; DRUG BLOOD LEVEL; DRUG EFFECT; DRUG SAFETY; DRUG TOLERABILITY; DYSPEPSIA; FEMALE; HEADACHE; HUMAN; HUMAN EXPERIMENT; MALE; NORMAL HUMAN; QT INTERVAL; SOMNOLENCE; STEADY STATE;

ADOLESCENT; ADULT; ANTIDEPRESSIVE AGENTS, SECOND-GENERATION; AREA UNDER CURVE; CISAPRIDE; DRUG INTERACTIONS; DRUG THERAPY, COMBINATION; ELECTROCARDIOGRAPHY; FLUOXETINE; GASTROINTESTINAL AGENTS; HEART RATE; HUMANS; MALE;

EID: 0035141043     PISSN: 02770008     EISSN: None     Source Type: Journal    
DOI: 10.1592/phco.21.2.149.34109     Document Type: Article

References (26)

1. Cisapride: A gastrointestinal prokinetic drug
2. Cisapride. An updated review of its pharmacology and therapeutic efficacy as a prokinetic agent in gastrointestinal motility disorders
3. A comparison of two cohort studies evaluating the safety of cisapride: Prescription-event monitoring and a large phase IV study
4. Review of the current status of prokinetic agents in gastroenterology
5. Cisapride and fatal arrhythmia
6. Review of spontaneous adverse event reports of serious ventricular arrhythmias, QT prolongation, syncope, and sudden death in patients treated with cisapride
7. The impact of gastroesophageal reflux disease on health-related quality of life
8. Psychological distress in patients with gastroesophageal reflux disease
9. Determinations of symptoms suggestive of gastroesophageal reflux disease in the elderly
10. Prescribing patterns of antidepressant medications for depression in a HMO
11. The safety profile of nefazodone
12. Rational drug use in the treatment of depression
13. The pharmacologic treatment of depression: Drug selection criteria
14. Inhibition by fluoxetine of cytochrome P450 2D6 activity
15. Pharmacokinetics of selective serotonin reuptake inhibitors
16. Clinically relevant pharmacology of selective serotonin reuptake inhibitors
17. Determination of cisapride in plasma and animal tissues by high-performance liquid chromatography
18. An analysis of the time-relations of electrocardiograms
19. An improved method for adjusting the QT interval for heart rate
20. Update: Clinically significant cytochrome P-450 drug interactions
21. The influence of cisapride and clarithromycin on QT intervals in healthy volunteers
22. Lack of correlation of cisapride levels with ECG changes
23. Targeted pharmacotherapy in depression management: Comparative pharmacokinetics of fluoxetine, paroxetine, and sertraline
24. Citalopram in the treatment of depression and other potential uses in psychiatry