Intracellular glutathione regulates tumour necrosis factor-α-induced p38 MAP kinase activation and RANTES production by human bronchial epithelial cells

Clinical and Experimental Allergy

Volumn 31, Issue 1, 2001, Pages 144-151

  Hashimoto, S ^a   Gon, Y ^a   Matsumoto, K ^a   Takeshita, I ^a   Machinoand, T ^a   Horie, T ^a  

^a NIHON UNIVERSITY   (Japan)

Author keywords

Bronchial epithelial cells; Glutathione; p38 MAP kinase; RANTES

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ACETYLCYSTEINE; BUTHIONINE SULFOXIMINE; CYTOKINE; GLUTATHIONE; MITOGEN ACTIVATED PROTEIN KINASE; RANTES; SYNAPTOPHYSIN; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; BRONCHUS MUCOSA; CYTOKINE PRODUCTION; EPITHELIUM CELL; HUMAN; HUMAN CELL; OXIDATION REDUCTION REACTION; PRIORITY JOURNAL; PROTEIN SYNTHESIS;

ACETYLCYSTEINE; BRONCHI; BUTHIONINE SULFOXIMINE; CELL LINE, TRANSFORMED; ENZYME ACTIVATION; EPITHELIAL CELLS; GENE EXPRESSION REGULATION; GLUTATHIONE; HUMANS; MITOGEN-ACTIVATED PROTEIN KINASES; P38 MITOGEN-ACTIVATED PROTEIN KINASES; RANTES; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0035137760     PISSN: 09547894     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2222.2001.00967.x     Document Type: Article

References (36)

1. Standards for the diagnosis and care of patients with chronic obstructive pulmonary disease (COPD) and asthma
2. Mucosal inflammation in asthma
3. Cells and eosinophils in the pathogenesis of asthma
4. Asthma and inflammation
5. Airway epithelial cells as regulator of airway inflammation
6. Expression of RANTES in human airway epithelial cells: Effects of corticosteroids and interleukin-4-10 and -13
7. Pro-eosinophilic cytokines in asthma
8. CC chemokines in allergic inflammation
9. MAPKs: New JNK expand the group
10. Map kinase targeted by endotoxin and hyperosmolarity in mammalian cells
11. Pro-inflammatory cytokines and enviromental stress cause p38 mitogen-activated protein kinase activation by dual phophorylation on tyrosine and threonine
12. Hyperosmolarity-induced IL-8 expression in human bronchial epithelial cells through p38 MAP kinase
13. Cooling and rewarming-induced IL-8 expression in human bronchial epithelial cells through p38 MAP kinase-dependent pathway
14. Proinflammatory cytokine- and chemical mediator-induced IL-8 expression in human bronchial epithelial cells through p38 MAP kinase-dependent pathway
15. 2
16. Stimulation of 'stress-regulated' mitogen-activated protein kinases (stress-activated protein kinases/c-jun N-terminal kinases and p38mitogen-activated protein kinase) in perfused rat hearts by oxidative and other stresses
17. p38 mitogen-activated protein kinase regulate TNF-α-, IL-1α,- and PAF-induced RANTES GM-CSF production by human bronchial epithelial cells
18. N-acetylcysteine inhibits IL-1α-induced IL-8 secretion by human bronchial epithelial cells
19. Thioredoxin negatively regulates p38 MAP kinase activation and IL-6 production by tumor necrosis factor-α
20. The metabolism of Nacetylcysteine by human endothelial cells
21. Physical and functional sensitivity of zinc finger transcription factors to redox changes
22. A protein kinase involved in the regulation of inflammatory cytokine biosynthesis
23. Determination of glutathione and glutathione disulfide in biological samples
24. A role of oxygen radicals as second messengers
25. Nuclear factor ScB: An oxidative stress-responsive transcriptional factor of eukaryotic cells
26. Human fibroblasts release reactive oxygen species in response to interluekin-1 and tumor necrosis factor-α
27. 2. Role of cell survival following oxidant injury
28. Hypoxia/reoxygenation stimulates Jun kinase activity through redox signaling in cardiac myocytes
29. Tumor necrosis factor alpha-induced apoptosis in human neural cells: Protection by the antioxidant N-acetylcyteine and the genes bcl-2 and crmA
30. HIV-induced cysteine deficiency and T-cell dysfunction - A rationale for treatment with N-acetylcysteine
31. The levels of intracellular glutathione is a key regulator for the induction of stress-activated signal transduction pathways including Jun N-terminal protein kinases and p38 kinase by alkylating agents
32. Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathway
33. Mammalian thioredoxin is a direct inhibitor of apoptosis signal regulating kinase (ASK) 1
34. Reactive oxygen species- and dimerization-induced activation of apoptosis signal-regulating kinase 1 in tumor necrosis factor-α signal transduction
35. Potential of N-acetylcysteine as treatment for the adult respiratory distress syndrome
36. N-acetylcysteine enhances recovery from acute lung injury in man. A randomized, double blind, placebo-controlled clinical study