Ion channel associated proteins

Current Opinion in Neurobiology

Volumn 6, Issue 5, 1996, Pages 602-608

  Sheng, Morgan ^a   Kim, Eunjoon ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM CHANNEL; ION CHANNEL; PROTEIN;

CELL FUNCTION; CHANNEL GATING; CYTOLOGY; ELECTROPHYSIOLOGY; NERVE CELL MEMBRANE POTENTIAL; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; REVIEW; SIGNAL TRANSDUCTION; SYNAPSE VESICLE;

EID: 0030273284     PISSN: 09594388     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0959-4388(96)80091-2     Document Type: Article

References (63)

1. Isom LL, De Jongh KS, Catterall WA. Auxiliary subunits of voltage-gated ion channels. Neuron. 12:1994;1183-1194.
2. + channel subtypes in central neurons. Neuron. 3:1989;695-704.
3. Ahlijanian MK, Westenbroek RE, Catterall WA. Subunit structure and localization of dihydropyridine-sensitive calcium channels in mammalian brain, spinal cord, and retina. Neuron. 4:1990;819-832.
4. + channel proteins in rat central neurons. Neuron. 9:1992;271-284.
5. Westenbroek R, Hell J, Warner C, Dubel S, Snutch T, Catterall WA. Biochemical properties and subcellular distribution of an N-type calcium channel α1 subunit. Neuron. 9:1992;1099-1115.
6. Phillips WD, Kopta C, Blount P, Gardner PD, Steinbach JH, Merlie JP. ACh receptor-rich membrane domains organized in fibroblasts by recombinant 43-kilodalton protein. Science. 251:1991;568-570.
7. Froehner SC. Regulation of ion channel distribution at synapses. Annu Rev Neurosci. 16:1993;347-368.
8. Apel ED, Merlie JP. Assembly of the postsynaptic apparatus. Curr Opin Neurobiol. 5:1995;62-67.
9. of outstanding interest Gautam M, Noakes PG, Mudd J, Nichol M, Chu GC, Sanes JR, Merlie JP. Failure of postsynaptic specialization to develop at neuromuscular junctions of rapsyn-deficient mice. Nature. 377:1995;232-236 Knocking out the rapsyn gene in mice abolishes nAChR and syntrophin clustering at the NMJ, but not synapse-specific transcription of nAChR subunit genes. Applying exogenous agrin yields no nAChR clustering, and motor axons show excessive growth and poor arborization. On the basis of these results, the authors suggest that rapsyn is critical for normal postsynaptic specialization.
10. of special interest Apel ED, Roberds SL, Campbell KP, Merlie JP. Rapsyn may function as a link between the acetylcholine receptor and the agrin-binding dystrophin-associated glycoprotein complex. Neuron. 15:1995;115-126 In co-transfected QT-6 fibroblasts, dystroglycan co-localizes with rapsyn clusters independently of nAChRs. Rapsyn is hypothesized to be the molecular link between nAChR and dystroglycan, connecting nAChRs to the cytoskeleton-anchored dystroglycan.
11. Maimone MM, Merlie JP. Interaction of the 43 kd postsynaptic protein with all subunits of the muscle nicotinic acetylcholine receptor. Neuron. 11:1993;53-66.
12. Kirsch J, Wolters I, Triller A, Betz H. Gephyrin antisense oligonucleotides prevent glycine receptor clustering in spinal neurons. Nature. 366:1993;745-748.
13. Kuhse J, Betz H, Kirsh J. The inhibitory glycine receptor: architecture, synaptic localization and molecular pathology of a postsynaptic ion-channel complex. Curr Opin Neurobiol. 5:1995;318-323.
14. of special interest Kirsch J, Betz H. The postsynaptic localization of the glycine receptor-associated protein gephyrin is regulated by the cytoskeleton. J Neurosci. 15:1995;4148-4156 To show gephyrin is linked to cytoskeletal components in vivo, the authors use alkaloids that affect microtubules and microfilaments. In cultured rat spinal cord neurons, disruption of microtubules correlates with a decreased number of cells with gephyrin clusters as well as the number of gephyrin clusters per cell. Actin depolymerization results in smaller but denser gephyrin clusters.
15. A receptor confers gephyrin-binding ability in overlay and co-clustering assays.
16. Kirsch J, Kuhse J, Betz H. Targeting of glycine receptor subunits to gephyrin-rich domains in transfected human embryonic kidney cells. Mol Cell Neurosci. 6:1995;450-461.
17. Jan LY, Jan YN. How might the diversity of potassium channels be generated? Trends Neurosci. 13:1990;415-418.
18. Moriyoshi K, Masu M, Ishii T, Shigemoto R, Mizuno N, Nakanishi S. Molecular cloning and characterization of the rat NMDA receptor. Nature. 354:1991;31-37.
19. Wisden W, Seeburg PH. Mammalian ionotropic glutamate receptors. Curr Opin Neurobiol. 3:1993;291-298.
20. Nakanishi S. Molecular diversity of glutamate receptors and implications for brain function. Science. 258:1992;597-603.
21. + channels detected in vivo. Nature. 365:1993;72-75.
22. + channels in terminal and juxtaparanodal regions of neurons. Nature. 365:1993;75-79.
23. + channel subunit in different neurons of rat brain. J Neurosci. 14:1994;2408-2417.
24. Siegel SJ, Brose N, Janssen WG, Gasic GP, Jahn R, Heinemann SF, Morrison JH. Regional, cellular, and ultrastructural distribution of N-methyl-D-aspartate receptor subunit 1 in monkey hippocampus. Proc Natl Acad Sci USA. 91:1994;564-568.
25. Petralia RS, Yokotani N, Wenthold RJ. Light and electron microscope distribution of the NMDA receptor subunit NMDAR1 in the rat nervous system using a selective anti-peptide antibody. J Neurosci. 14:1994;667-696.
26. Aoki C, Venkatesan C, Go C-G, Mong JA, Dawson TM. Cellular and subcellular localization of NMDA-R1 subunit immunoreactivity in the visual cortex of adult and neonatal rats. J Neurosci. 14:1994;5202-5222.
27. Liu H, Wang H, Sheng M, Jan LY, Jan YN, Basbaum AI. Evidence for presynaptic N-methyl-D-aspartate autoreceptors in the spinal cord dorsal horn. Proc Natl Acad Sci USA. 91:1994;8383-8387.
28. +-channel clustering and insightful questions for future studies.
29. + channel and PSD-95 in heterologous cells results in the formation of co-clusters, suggesting that members of the family could be involved in aggregation of synaptic membrane proteins.
30. of special interest Kornau H-C, Schenker LT, Kennedy MB, Seeburg PH. Domain interaction between NMDA receptor subunits and the postsynaptic density protein PSD-95. Science. 269:1995;1737-1740 Using the yeast two-hybrid system and in vitro binding assays, the authors demonstrate a domain interaction between the carboxy-terminal tail of NR2 subunits and the second PDZ domain of PSD-95. NR2B and PSD-95 co-localize in the dendritic spines of cultured hippocampal neurons. A list of membrane proteins carrying a terminal T/SXV motif (where T/S is threonine/serine, X is any amino acid, and V is valine) is presented.
31. of outstanding interest Niethammer M, Kim E, Sheng M. Interaction between the C terminus of NMDA receptor subunits and multiple members of the PSD-95 family of membrane-associated guanylate kinases. J Neurosci. 16:1996;2157-2163 This paper describes the interaction between the carboxy-terminal tail of NR2 subunits and multiple members of the PSD-95/SAP90 family. The first two PDZ repeats of PSD-95, individually or in combination, interact with the carboxy-terminal tail of NR2 subunits. Binding of NR2 subunits to PDZ1 is important because nNOS appears to antagonize NR2 binding to PDZ2.
32. Woods DF, Bryant PJ. The discs-large tumor suppressor gene of Drosophila encodes a guanylate kinase homolog localized at septate junctions. Cell. 66:1991;451-464.
33. Cho K-O, Hunt CA, Kennedy MB. The rat brain postsynaptic density fraction contains a homolog of the Drosophila discs-large tumor suppressor protein. Neuron. 9:1992;929-942.
34. Kistner U, Wenzel BM, Veh RW, Cases-Langhoff C, Garner AM, Appeltauer U, Voss B, Gundelfinger ED, Garner CC. SAP90, a rat presynaptic protein related to the product of the Drosophila tumor suppressor gene dlg-A. J Biol Chem. 268:1993;4580-4583.
35. Hunt CA, Schenker LJ, Kennedy MB. PSD-95 is associated with the postsynaptic density and not with the presynaptic membrane at forebrain synapses. J Neurosci. 16:1996;1380-1388.
36. Müller BM, Kistner U, Veh RW, Cases-Langhoff C, Becker B, Gundelfinger ED, Garner CC. Molecular characterization of spatial distribution of SAP97, a novel presynaptic protein homologous to SAP90 and the Drosophila discs-large tumor suppressor protein. J Neurosci. 15:1995;2354-2366.
37. Lue RA, Marfatia SM, Branton D, Chishti AH. Cloning and characterization of hdlg: the human homologue of the Drosophila discs large tumor suppressor binds to protein 4.1. Proc Natl Acad Sci USA. 91:1994;9818-9822.
38. of outstanding interest Brenman JE, Chao DS, Gee SH, McGee AW, Craven SE, Santillano DR, Wu Z, Huang F, Xia H, Peters MF, et al. Interaction of nitric oxide synthase with the postsynaptic density protein PSD-95 and α1-syntrophin mediated by PDZ domains. Cell. 84:1996;757-767 The single PDZ domain in the amino-terminal region of nNOS interacts with the second PDZ domain of PSD-95 and the PDZ domain of α1-syntrophin. This apparently homophilic interaction is competitive with PSD-95 PDZ binding to the terminal T/SXV motif.
39. Kim E, Cho KO, Rothschild A, Sheng M. Heteromultimerization and NMDA receptor-clustering activity of chapsyn-110, a member of the PSD-95 family of proteins. Neuron. 17:1996;103-113.
40. Müller BM, Kistner U, Kindler S, Chung WJ, Kuhlendahl S, Lau L-F, Veh RW, Huganir RL, Gundelfinger ED, Garner CC. SAP102, a novel postsynaptic protein that interacts with the cytoplasmic tail of the NMDA receptor subunit NR2B. Neuron. 17:1996;255-265.
41. of outstanding interest Doyle D, Lee A, Lewis J, Kim E, Sheng M, MacKinnon R. Crystal structure of a complexed and peptide-free membrane protein tethering domain: molecular basis of peptide recognition by PDZ. Cell. 85:1996;1067-1076 The first report of an X-ray crystallographic structure of a PDZ domain. The three-dimensional structure of the PDZ3 domain from PSD-95 complexed with its peptide ligand explains the specificity of the PDZ interaction with the carboxy-terminal four amino acids of the peptide. Recognition of the peptide's terminal carboxylate group is conferred by a `GLGF loop' (Gly-Leu-Gly-Phe) and an arginine side chain, which are highly conserved in the PDZ domains of chapsyns.
42. Lahey T, Gorczyca M, Jia X-X, Budnik V. The Drosophila tumor suppressor gene dlg is required for normal synaptic bouton structure. Neuron. 13:1994;823-835.
43. Rosenmund C, Westbrook GL. Calcium-induced actin depolymerization reduces NMDA channel activity. Neuron. 10:1993;805-814.
44. Paoletti P, Ascher P. Mechanosensitivity of NMDA receptors in cultured mouse central neurons. Neuron. 13:1994;645-655.
45. Bennett MK, Calakos N, Scheller RH. Syntaxin: a synaptic protein implicated in docking of synaptic vesicles at presynaptic active zones. Science. 257:1992;255-259.
46. Yoshida A, Oho C, Omori A, Kuwahara R, Ito T, Takahashi M. HPC-1 is associated with synaptotagmin and ω-conotoxin receptor. J Biol Chem. 267:1992;24925-24928.
47. Lévêque C, El Far O, Martin-Moutot N, Sato K, Kato R, Takahashi M, Seagar MJ. Purification of the N-type calcium channel in association with syntaxin and synaptotagmin. A complex implicated in synaptic vesicle exocytosis. J Biol Chem. 269:1994;6306-6312.
48. Sheng Z-H, Rettig J, Takahashi M, Catterall WA. Identification of a syntaxin-binding site on N-type calcium channels. Neuron. 13:1994;1303-1313.
49. 2+, close to the threshold for transmitter release.
50. 2+ channels with the presynaptic proteins syntaxin and SNAP-25. Proc Natl Acad Sci USA. 93:1996;7363-7368.
51. 1 subunit. Nature. 368:1994;67-70.
52. 2+ channel regulation by a conserved β subunit domain. Neuron. 13:1994;495-503.
53. 2+ channel reveals an extracellular immunoglobulin-like motif similar to the neuronal cell-adhesion molecule contactin. Injection of β2 mRNA into oocytes by itself can increase the cell-membrane surface area up to fourfold.
54. + channels from bovine brain. Proc Natl Acad Sci USA. 91:1994;1637-1641.
55. + channels altered by presence ofβ-subunit. Nature. 369:1994;289-294.
56. + channel.
57. + channel surface expression through effects early in biosynthesis. Neuron. 16:1996;843-852 When co-expressed in heterologous cells, Kvβ2 associates with Kv1.2 early in biosynthesis, and exerts a chaperone-like effect on Kv1.2, promoting cotranslational N-linked glycosylation, stability and surface expression of Kv1.2. The authors hypothesize a more fundamental role for Kvβ subunits than modulation of inactivation kinetics.
58. of special interest Yu W, Xu J, Li M. NAB domain is essential for the subunit assembly of both α-α and α-β complexes of shaker-like potassium channels. Neuron. 16:1996;441-453 Using patch-clamp analysis and yeast two-hybrid assays, the authors find that Kvβ1 interacts specifically with α subunits of Kv1 subfamily, but not of Kv2, Kv3, or Kv4 subfamilies. The specificity is determined by a site in the amino-terminal cytoplasmic region of the α subunits that overlaps with the one involved in the association of α-α subunits.
59. Stern M, Ganetzky B. Altered synaptic transmission in Drosophila hyperkinetic mutants. J Neurogenet. 5:1989;215-228.
60. Körschen HG, Illing M, Seifert R, Sesti F, Williams A, Gotzes S, Colville C, Müller F, Dosé A, Godde M, et al. A 240 kDa protein represents the complete β subunit of the cyclic nucleotide-gated channel from rod photoreceptor. Neuron. 15:1995;627-636.
61. 2δ subunit in current stimulation and subunit interaction. Neuron. 16:1996;431-440.
62. Srinivasan Y, Elmer L, Davis J, Bennett V, Angelides K. Ankyrin and spectrin associate with voltage-dependent sodium channels in brain. Nature. 333:1988;177-180.
63. Tanabe T, Beam KG, Adams BA, Niidome T, Numa S. Regions of the skeletal muscle dihydropyridine receptor critical for excitation-contraction coupling. Nature. 346:1990;567-569.