Isolation and sequencing of the cDNA of a novel cythochrome P450 from rat oesophagus

Carcinogenesis

Volumn 22, Issue 1, 2001, Pages 155-160

  Brookman Amissah, Nicola ^a   Mackay, Alan G ^a   Swann, Peter F ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; CARCINOGEN; COMPLEMENTARY DNA; CYTOCHROME P450 2B1; CYTOCHROME P450 2B2; CYTOCHROME P450 2B21; CYTOCHROME P450 ISOENZYME; NITROSAMINE; UNCLASSIFIED DRUG;

3' UNTRANSLATED REGION; 5' UNTRANSLATED REGION; AMINO ACID SEQUENCE; ANIMAL TISSUE; ARTICLE; CARCINOGENESIS; CATALYSIS; CONTROLLED STUDY; DNA LIBRARY; DNA SEQUENCE; ENZYME ACTIVITY; ESOPHAGUS; GENE AMPLIFICATION; GENE ISOLATION; GENETIC SCREENING; HYDROXYLATION; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEQUENCE HOMOLOGY;

AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; CLONING, MOLECULAR; CYTOCHROME P-450 ENZYME SYSTEM; DNA PRIMERS; DNA, COMPLEMENTARY; ESOPHAGUS; LIVER; MOLECULAR SEQUENCE DATA; RATS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SEQUENCE HOMOLOGY, AMINO ACID;

EID: 0035134927     PISSN: 01433334     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (35)

1. Changing patterns in the incidence of esophageal and gastric carcinoma in the United States
2. Genetic alterations in esophageal cancer and their relevance to etiology and pathogenesis: A review
3. p53 and human cancer: The first ten thousand mutations
4. Esophageal and hepatic microsomal metabolism of N-nitrosomethylbenzylamine and N-nitrosodimethylamine in the rat
5. 3H-pentyl]methyl-n-amylnitrosamine by rat esophageal and liver microsomes and by rat and human cytochrome P450 isoforms
6. Expression of cytochrome P450 2A3 in rat esophagus: Relevance to N-nitrosobenzylmethylamine
7. N-Nitrosobenzylmethylamine hydroxylation and coumarin 7-hydroxylation: Catalysis by rat esophageal microsomes and cytochrome P450 2A3 and 2A6 enzymes
8. Mechanism of esophageal tumor-induction in rats by N-nitrosomethylbenzylamine and its ring-methylated analog N-nitrosomethyl(4-methylbenzyl)amine
9. DNA methylation in rat tissues by a series of homologous aliphatic nitrosamines ranging from N-nitrosodimethylamine to N-nitrosomethyl-dodecylamine
10. DNA methylation in various rat tissues by the esophageal carcinogen N-nitrosomethyl-n-amylamine and six of its positional isomers
11. Substrate specificity and alkyl group selectivity in the metabolism of N-nitrosodialkylamines
12. Use of monoclonal antibodies to cytochrome P450s to indicate the critical dealkylation and the P450s involved in methyl-n-amylnitrosamine mutagenicity in the presence of induced rat liver microsomes
13. Cytochromes P450 2B1 and P450 2B2 demethylate N-nitrosodimethylamine and N-nitrosomethylaniline in vitro
14. Metabolism of carcinogenic N-nitroso-N-methylaniline by purified cytochromes P450 2B1 and P450 2B2
15. Identification of the cytochrome P450 isozymes involved in the metabolism of N-nitrosodipropyl-, N-nitrosodibutyl- and N-nitroso-n-butyl-n-propylamine
16. Alkylation of cellular macromolecules and target specificity of carcinogenic nitrosodialkylamines: Metabolic activation by cytochromes P450 2B1 and 2E1
17. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
18. Identification of a cytochrome P450 gene by reverse transcription-PCR using degenerate primers containing inosine
19. A keratinocyte-specific epoxygenase, CYP2B12, metabolizes arachidonic acid with unusual selectivity, producing a single major epoxyeicosatrienoic acid
20. On the membrane topology of vertebrate cytochrome P-450 proteins
21. Secondary structure prediction of 52 membrane-bound cytochromes P450 shows a strong structural similarity to P450cam
22. Importance of the proline-rich region following signal-anchor sequence in the formation of correct conformation of microsomal cytochrome P-450s
23. An analysis of 5′-noncoding sequences from 699 vertebrate messenger RNAs
24. Sequence of a novel cytochrome CYP2B cDNA coding for a protein which is expressed in a sebaceous gland, but not in the liver
25. Positional specificity for methyl-n-amylnitrosamine hydroxylation by cytochrome P-450 isozymes determined with monoclonal antibodies
26. Hydroxylation and dealkylation of methyl-n-butylnitrosamine and role of certain cytochrome P-450 isozymes in these reactions
27. Multiple sequence alignment with hierachical clustering
28. Gene structure of a phenobarbital-inducible cytochrome P-450 in rat liver
29. Cloning and sequence analysis of a rat liver cDNA coding for a phenobarbital-inducible microheterogenous cytochrome P-450 variant: Regulation of its messenger level by xenobiotics
30. A constitutive member of the rat cytochrome P450IIB subfamily: Full-length coding sequence of the P450IIB3 cDNA
31. Primary structure of a cytochrome P-450: Coding nucleotide sequence of phenobarbital-inducible cytochrome P-450 from rat liver