Anomalies of the CD8+ T cell pool in haemochromatosis: HLA-A3-linked expansions of CD8+CD28- T cells

Clinical and Experimental Immunology

Volumn 107, Issue 3, 1997, Pages 548-554

  Arosa, F A ^a   Oliveira, L ^a   Porto, G ^a,b   Da Silva, B M ^a   Kruijer, W ^a   Veltman, J ^a   De Sousa, M ^a  

^a UNIVERSITY OF PORTO   (Portugal)

^b HOSPITAL DE SANTO ANTÓNIO   (Portugal)

Author keywords

CD28 expression; CD8+ T cells; Haemochromatosis; HLA A3; Iron metabolism

Indexed keywords

CD28 ANTIGEN; CD45 ANTIGEN; CD8 ANTIGEN; HLA A3 ANTIGEN;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; FEMALE; HEMOCHROMATOSIS; HLA SYSTEM; HUMAN; HUMAN CELL; IRON OVERLOAD; MALE; PHENOTYPE; PRIORITY JOURNAL; T LYMPHOCYTE SUBPOPULATION;

EID: 0031041860     PISSN: 00099104     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2249.1997.d01-967.x     Document Type: Article

References (31)

1. Lum LG, Orkut-Thordarson N, Seigneuret MC et al. In vitro regulation of immunoglobin synthesis by T cell subpopulations defined by a new T cell antigen (9.3). Cell Immunol 1982; 72:122-9.
2. Yamada H, Martin PJ, Bean MA et al. Monoclonal antibody 9·3 and anti-CD11b antibodies define reciprocal subsets of lymphocytes. Eur J Immunol 1985; 15:1164-8.
3. - lymphocytes: antigenic and functional properties. J Immunol 1993; 150:1147-59.
4. Posnett DN, Sinha R, Kabak S et al. Clonal populations of T cells in normal elderly humans: the T cell equivalent to 'benign monoclonal gammmopathy'. J Exp Med 1994; 179:609-18.
5. + subset. J Immunol 1995; 154:6182-90.
6. + T cell expansions in normal individuals and patients with reumatoid arthritis. J Immunol 1995; 154:3538-47.
7. + lymphocytes in patients with rheumatoid arthritis: correlation with duration of disease. Arthritis Rheum 1993; 36:608-12.
8. + lymphocytes in patients with Crohn's disease. Immun Infekt 1993; 21:5-8.
9. + T lymphocytes during HIV-1 infection. J Acquir Immun Def Syndr 1994; 7:245-53.
10. Dutra WO, Martins-Filho OA, Cançado JR et al. Chagasic patients lack CD28 expression on many of their circulating T lymphocytes. Scand J Immunol 1996; 43:88-93.
11. Laughran TP. Clonal diseases of large granular lymphocytes. Blood 1993; 82:1-14.
12. Winton EF, Chan WC, Check I et al. Spontaneous regression of a monoclonal proliferation of large granular lymphocytes associated with reversal of anemia and neutropenia. Blood 1986; 67:1427-32.
13. van Oostveen JW, Ploem JE, Brandt RMP et al. Remission of monoclonal chronic T cell expansion associated with severe anemia. Leukemia Res 1991; 15:1167-74.
14. Weiss G, Wachter H, Fuchs D. Linkage of cell-mediated immunity to iron metabolism. Immunol Today 1995; 16:495-500.
15. de Sousa M, Reimão R, Porto G et al. Iron and lymphocytes: reciprocal regulatory interactions. In: Albertini A, Leufaut CL, Mannucci PM et al., eds. Curr Stud Haematol Blood Transf. Basel: Karger, 1991; 58:171-7.
16. Reimão R, Porto G, de Sousa M. Stability of CD4/CD8 ratios in man: new correlation between CD4/CD8 profiles and iron overload in idiopathic hemochromatosis patients. CR Acad Sci Paris 1991; 313:481-7.
17. + lymphocytes and iron overload. Eur J Haematol 1994; 52:283-90.
18. Arosa FA, da Silva AJ, Godinho IM et al. Decreased CD8-p56lck activity in peripheral blood T lymphocytes from patients with hereditary hemochromatosis. Scand J Immunol 1994; 39:426-32.
19. Porto G, Vicente C, Teixeira MA et al. Relative impact of HLA phenotype and CD4/CD8 ratios on the clinical expression of haemochromatosis. Hepatology 1997; 25:in press.
20. + population in genetic hemochromatosis: characterization of the T cell repertoire. FASEB J 1995; A527 (Abstr.).
21. Feder JN, Gnirke A, Thomas W et al. A novel MHC class I-like gene is mutated in patients with hereditary hemochromatosis. Nat Genet 1996; 13:399-408.
22. Porto G, Vicente C, Fraga J et al. The importance of establishing appropriate local reference values for the screening of haemochromatosis: a study of 3 different control populations and 136 haemochromatosis family members. J Clin Lab Med 1992; 119:295-305.
23. Vicente C, Porto G, de Sousa M. Method for establishing serum ferritin reference values depending on sex and age. J Clin Lab Med 1990; 116:779-84.
24. Scheuer PJ. Liver biopsy interpretation. London: Baillière Tindall 1980.
25. Sokal RR, Rohlf FJ. Computation of the product-moment correlation coefficient. In: Emerson R, Kennedy D, Park RB et al., eds. Biometry: the principles and practice of statistics in biological research. San Francisco: W.H. Freeman and Co., 1969:508-15.
26. Steel RG, Torrie JH. Principles and procedures of statistics. A biomedical approach, 2nd edn. New York: McGraw Hill Book Co., 1980:311-33.
27. Simon M, Yaouang J, Fauchet R et al. Genetics of hemochromatosis: HLA-associations and mode of inheritance. Ann NY Acad Sci 1988; 526:11-22.
28. + T cells. J Immunol 1993; 151:2237-46.
29. + T cell activation is mediated through CD8 and the activation of CD8-associated p56lck. J Exp Med 1995; 182:1079-88.
30. Karnitz L, Sutor SL, Torigoe T et al. Effects of p56lck deficiency on the growth and cytolytic effector function of an interukin-2-dependent cytotoxic T-cell line. Mol Cell Biol 1992; 12:4521-30.
31. Stremmel W, Riedel HD, Niederau C et al. Pathogenesis of genetic hemocromatosis. Eur J Clin Invest 1993; 23:321-9.