Comparison of 99mTc-sestamibi and doxorubicin to monitor inhibition of P-glycoprotein function

British Journal of Cancer

Volumn 84, Issue 3, 2001, Pages 367-373

  Muzzammil, T ^a,b   Moore, M J ^a,b,c   Hedley, D ^a,b,c   Ballinger, J R ^a,b  

^a UNIVERSITY OF TORONTO   (Canada)

^b PRINCESS MARGARET HOSPITAL   (Canada)

^c ADDENBROOKE S HOSPITAL   (United Kingdom)

Author keywords

99mTc sestamibi; Doxorubicin; Flow cytometry; MCF7 human breast carcinoma cell line; P glycoprotein; Radionuclide imaging

Indexed keywords

DOXORUBICIN; ELACRIDAR; GLYCOPROTEIN P; METHOXY ISOBUTYL ISONITRILE TECHNETIUM TC 99M; VALSPODAR; ZOSUQUIDAR;

ARTICLE; CANCER RESISTANCE; CELL SELECTION; CELL STRAIN MCF 7; CONTROLLED STUDY; DRUG UPTAKE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; MULTIDRUG RESISTANCE; PATIENT MONITORING; PRIORITY JOURNAL; SCINTISCANNING;

ACRIDINES; ANTINEOPLASTIC AGENTS; BLOTTING, WESTERN; CELL SURVIVAL; CYCLOSPORINS; DOSE-RESPONSE RELATIONSHIP, DRUG; DOXORUBICIN; GENES, MDR; HUMANS; IMMUNOHISTOCHEMISTRY; ISOQUINOLINES; P-GLYCOPROTEINS; RADIOPHARMACEUTICALS; TECHNETIUM TC 99M SESTAMIBI; TETRAHYDROISOQUINOLINES; TIME FACTORS; TUMOR CELLS, CULTURED;

EID: 0035129713     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1054/bjoc.2000.1621     Document Type: Article

References (37)

1. m-sestamibi as an agent for imaging P-glycoprotein-mediated multdrug resistance: In vitro and in vivo studies in rat breast tumour cell line and its doxorubicin-resistant variant
2. Technetium-99m-tetrofosmin as a substrate for P-glycoprotein: In vitro studies in multidrug resistant breast tumor cells
3. Technetium-99m furifosmin as an agent for functional imaging of multidrug resistance in tumors
4. Overexpression of a novel anionic glutathione-transferase in multidrug resistant human breast cancer cell line
5. Transfer of adriamycin resistance by fusion of Mr 170,000 P-glycoprotein to the plasma membrane of sensitive cells
6. Regulation of cellular glutathione modulates nuclear accumulation of daunorubicin in human MCF7 cells overexpressing multidrug resistance associated protein
7. Mechanism of drug resistance
8. Quality control of multidrug resistance assays in adult leukemia: Correlation between assays for P-glycoprotein expression and activity
9. Expression of multidrug resistance-associated protein in NIH/3T3 cells confers multidrug resistance associated with increased drug efflux and altered intracellular drug distribution
10. 3H-daunomycin uptake in human carcinoma cells: Relation to the MDR phenotype and effects of reversing agents
11. Methods in laboratory investigation: A sensitive method for immunohistochemical detection of P-glycoprotein in multidrug resistant human ovarian carcinoma cell lines
12. Effects of mitochondrial and plasma membrane potentials on accumulation of hexakis (2-methoxy isobutyl isonitrile) technetium (I) in cultured mouse fibroblasts
13. Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell line
14. Novel technetium (III)-Q complexes for functional imaging of multidrug resistance (MDRI) P-glycoprotein
15. Reversal of P-glycoprotein-mediated multidrug resistance by a potent cyclopropyldibenzosuberane modulator, LY335979
16. Mitochondrial and plasma membrane potentials cause unusual accumulation and retention of rhodamine 123 by human breast adenocarcinoma-derived MCF-7 cells
17. In vivo detection of multidrug resistance (MDR-1) phenotype by technetium-99m-sestamibi scan in untreated breast cancer patients
18. Clinical imaging of multidrug resistance in cancer
19. Multidrug resistance in cells transfected with human gene encoding a variant of P-glycoprotein and glutathione-S-transferase-π
20. Pharmacology of drugs that alter multi drug resistance in cancer
21. 99mTc-sestamibi is a substrate for P-glycoprotein and the multidrug resistance-associated protein
22. Visualization of muttidrug resistance in vivo
23. In vitro and in vivo reversal of multidrug resistance by GF 120918, an acridonecarboxamide derivative
24. Characterization of multidrug resistance by fluorescent dyes
25. Expression of the MDR transporter, P-glycoprotein, in acute leukemia cells and correlation to clinical drug resistance
26. Kinetics of anthracycline efflux from multidrug resistance protein-expressing cancer cells compared with P-glycoprotein-expressing cancer cells
27. m-sestamibi imaging of inhibition of the multidrug resistance transporter in a mouse xenograft model of human breast cancer
28. Functional imaging of multidrug resistance P-glycoprotein with an organotechnetium complex
29. Multidrug resistance associated protein gene overexpression and reduced drug sensitivity to topoisomerase-II in human breast carcinoma MCF7 celt line selected for etoposide resistance
30. Functional multidrug resistance phenotype associated with combined overexpression of Pgp/MDRI and MRP together with 1-β-D-arabinofuranosylcytosine sensitivity may predict clinical response in acute myeloid leukemia
31. Differentiation state and invasiveness of human breast cancer cell lines
32. Adriamycin metabolism in man: Evidence from urinary metabolites
33. Multidrug resistance in breast cancer: A meta-analysis of MDR1/gp170 expression and its possible functional significance
34. The influence of celt concentration in limiting the therapeutic benefit of P-glycoprotein reversal agents
35. Modification of cytotoxic drug resistance by non-immunosuppressive cyclosporins
36. 99mTc-MIBI in cells with P-glycoprotein-mediated and multidrug-resistance protein-associated multidrug-resistance phenotypes
37. Discordant P-glycoprotein antigen expression and transport function in acute myeloid leukemia