Suppression of mammary carcinoma growth in vitro and in vivo by inducible expression of the Cdk inhibitor p21

Cancer Gene Therapy

Volumn 8, Issue 1, 2001, Pages 23-35

  Shibata, Masa Aki ^a,b   Yoshidome, Katsuhide ^a   Shibata, Eiko ^a   Jorcyk, Cheryl L ^c   Green, Jeffrey E ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b OSAKA MEDICAL COLLEGE   (Japan)

^c BOISE STATE UNIVERSITY   (United States)

Author keywords

Cell cycle; Gene therapy; Mammary cancer; P21; Transgenic mice

Indexed keywords

CYCLIN D1; CYCLIN DEPENDENT KINASE; CYCLIN DEPENDENT KINASE 2; CYCLIN DEPENDENT KINASE 4; CYCLIN DEPENDENT KINASE 6; CYCLIN E; PROTEIN P21; PROTEIN P27; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BREAST CARCINOMA; CANCER GROWTH; CANCER MODEL; CANCER THERAPY; CELL PROLIFERATION; CONTROLLED STUDY; FEMALE; GENE OVEREXPRESSION; GENE THERAPY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RETROVIRUS; TRANSGENIC MOUSE;

ANIMALIA; MUS MUSCULUS; UNIDENTIFIED RETROVIRUS;

EID: 0035128134     PISSN: 09291903     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.cgt.7700275     Document Type: Article

References (39)

1. Checkpoints: Controls that ensure the order of cell cycle events
2. Cyclins and cancer: Il. Cyclin D and CDK inhibitors come of age
3. Joining the complex: Cyclin-dependent kinase inhibitory proteins and the cell cycle
4. WAF1 expression and endocrine response in breast cancer
5. WAF1, a potential mediator of p53 tumor suppression
6. Genetic basis for p53 overexpression in human breast cancer
7. p53 mutations in human cancers
8. Immunohistochemical detection of p53 protein in mammary carcinoma: An important new independent of prognosis?
9. p21 (Waf1/Cip1) and p53 protein expression in breast cancer
10. Cell cycle expression and p53 regulation of the cyclin-dependent kinase inhibitor p21
11. WAF1/CIP1 is induced in p53-mediated G1 arrest and apoptosis
12. Differential effects by the p21 CDK inhibitor on PCNA-dependent DNA replication and repair
13. The p21 cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases
14. Waf1/CIp1 induces growth arrest, giant cell formation and apoptosis in human breast carcinoma cell lines
15. WAF1 induces permanent growth arrest and enhances differentiation, but does not alter apoptosis in PC12 cells
16. p21Waf1/Cip1/Sdi1 in cell death and DNA repair as studied using a tetracycline-inducible system in p53-deficient cells
17. The p21 cyclin-dependent kinase inhibitor suppresses tumorigenicity in vivo
18. WAF1 adenoviral gene transfer in lung cancer
19. WAF1/CIP1 enhances tumor cell proliferation and cyclin D1-associated kinase activity in a murine mammary cancer model
20. p53-independent apoptosis during mammary tumor progression in C3(1)/SV40 large T antigen transgenic mice: Suppression of apoptosis during the transition from preneoplasia to carcinoma
21. The C3(1)/SV40 T-antigen transgenic mouse model of mammary cancer: Ductal epithelial cell targeting with multistage progression to carcinoma
22. Prostate and mammary adenocarcinoma in transgenic mice carrying a rat C3(1) simian virus 40 large tumor antigen fusion gene
23. The C3(1)/SV40 T antigen transgenic mouse model of prostate and mammary cancer
24. Cyclins and breast cancer
25. Antigen retrieval in formalin-fixed, paraffin-embedded tissues: An enhancement method for immunohistochemical staining based on microwave oven heating of tissue sections
26. Molecular cloning, sequencing, chromosomal localization and expression of mouse p21 (Waf1)
27. Tight control of gene expression in mammalian cells by tetracycline-responsive promoters
28. Production of high-titer helper-free retroviruses by transient transfection
29. Overexpression of E2F1 in glioma triggers apoptosis and suppress tumor growth in vitro and in vivo
30. Interactions between SV40 large-tumor antigen and the growth suppressor proteins pRB and p53
31. Subunit rearrangement of the cyclin-dependent kinases is associated with cellular transformation
32. Alterations in cell cycle and apoptosis regulatory genes during mammary tumor progression in C3(1)/TAg transgenic mice: Abrogation of the p21 pathway
33. Mutation of cell cycle regulators: Biological and clinical implications for human neoplasia
34. p27, a novel inhibitor of G1 cyclin-Cdk protein kinase activity, is related to p21
35. Interleukin-2-mediated elimination of the p27Kip1 cyclin-dependent kinase inhibitor prevented by rapamycin
36. Reciprocal changes in p27Kip1 and p21Cip1 in growth inhibition mediated by blockade or overstimulation of epidermal growth factor receptor
37. The absence of p21CIP1/WAF1 alters keratinocyte growth and differentiation and promotes ras-tumor progression
38. Absence of WAF1 mutations in a variety of human malignancies
39. p21WAF1 mutations and human malignancies