Interictal spikes increase cerebral glucose metabolism and blood flow: A PET study

Epilepsia

Volumn 40, Issue 2, 1999, Pages 170-178

  Bittar, R G ^a   Andermann, F ^a   Olivier, A ^a   Dubeau, F ^a   Dumoulin, S O ^a   Pike, G B ^a   Reutens, D C ^a,b  

^a MCGILL UNIVERSITY   (Canada)

^b AUSTIN HEALTH   (Australia)

Author keywords

Energy; Epilepsy; Glucose; Interictal spikes; PET

Indexed keywords

GLUCOSE; LAMOTRIGINE; PHENOBARBITAL; PHENYTOIN;

ADULT; ARTICLE; AUTORADIOGRAPHY; BLOOD FLOWMETRY; CASE REPORT; DISEASE ASSOCIATION; ELECTROENCEPHALOGRAM; GLUCOSE BRAIN LEVEL; HUMAN; HUMAN CELL; HUMAN TISSUE; MALE; NUCLEAR MAGNETIC RESONANCE IMAGING; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; REFLEX EPILEPSY; SPIKE WAVE;

ADULT; BRAIN; ELECTROENCEPHALOGRAPHY; EPILEPSY; FLUORODEOXYGLUCOSE F18; GLUCOSE; HUMANS; MAGNETIC RESONANCE IMAGING; MALE; OXYGEN RADIOISOTOPES; REGIONAL BLOOD FLOW; TOMOGRAPHY, EMISSION-COMPUTED; WATER;

EID: 0032957403     PISSN: 00139580     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1528-1157.1999.tb02071.x     Document Type: Article

References (46)

1. 3. Ann Neurol 1980;8:348-60.
2. Engel J. Kuhl DE, Phelps ME, Mazziotta JC. Interictal cerebral glucose metabolism in partial epilepsy and its relation to EEG changes. Ann Neurol 1982;12:510-7.
3. Sackellares JC. Abou-Khalil BW, Siegel GJ, et al. PET studies of interictal, ictal, and postictal changes in local cerebral blood flow in temporal lobe epilepsy. Neurology 1986;36(suppl 1):338.
4. Abou-Khalil BW, Siegel GJ, Sackellares JC, Gilman S, Hichwa R. Marshall R. Positron emission tomography studies of cerebral glucose metabolism in chronic partial epilepsy. Ann Neurol 1987;22: 480-6.
5. Theodore WH, Fishbein D, Dubinsky R, Patterns of cerebral glucose metabolism in patients with partial seizures, Neurology 1988; 38:1201-6.
6. Chee MWL, Morris HH, Antar MA. et al. Presurgical evaluation of temporal lobe epilepsy using interictai temporal spikes and positron emission tomography. Arch Neurol 1993;50:45-8.
7. 18F]fluorodeoxyglucose PET data. Brain 1996;119:337-92.
8. 18F]Fluorodeoxyglucose positron emission tomography in refractory complex partial seizures. Ann Neurol 1983;14:429-37.
9. Chugani HT, Shewmon DA, Khanna S, et al. Interictal and postictal hypermetabolism on positron emission tomography. Pediatr Neurol 1993;9:10-5.
10. Handforth A, Cheng JT, Mandelkern MA, Treiman DM. Markedly increased mesiotemporal lobe metabolism in a case with PLEDs: further evidence that PLEDs are a manifestation of partial status epilepticus. Epilepsia 1994:35:876-81.
11. 14C]glucose uptake and c-fos-like reactivity. Ann Neurol 1994;35:724-31.
12. Evans AC, Marrett S, Neelin P, et al. Anatomic mapping of functional activation in stereotactic coordinate space. Neuroimage 1992;1:43-53.
13. Worsely KJ, Evans AC, Marrett S, Neelin P, A three-dimensional statistical atlas for CBF activation studies in human brain. J Cereb Blood Flow Metab 1992;12:900-19.
14. 18FDG studies. In: Myers R, Cunningham V, Bailey D, Jones T. eds. Quantification of brain function using PET. San Diego: Academic Press, 1996;214-8.
15. 18FDG double injection and new graphical analysis. In: Myers R, Cunningham V, Bailey D, Jones T, eds. Quantification of brain function using PET. San Diego: Academic Press, 1996;421-4.
16. Woods RP, Mazziotta JC, Cherry SR, MRI-PET registration with automated algorithm. J Comput Assist Tomogr 1993;17:536-46.
17. Woods RP, Cherry SR, Mazziotta JC, Rapid automated method for aligning and reslicing PET images. J Comput Assist Tomogr 1992; 16:620-33.
18. Talairach J, Tournoux P. Co-planar stereotaxic atlas of the human brain. New York: Thieme, 1988.
19. Olivier A, Germano I, Cukiert A, Peters T. Frameless stereotaxy for surgery of the epilepsies: preliminary experience. J Neurosurg 1994;81:629-33.
20. 99mTc-HMPAO single positron emission computed tomography in children with temporal lobe epilepsy. Epilepsia 1993; 34:869-77.
21. Newton MR, Austin MC, Chan JG, McKay WJ, Rowe CC, Berkovic SF. Ictal SPECT using technetium-99m-HMPAO: methods for rapid preparation and optimal development of tracer during spontaneous seizures. J Nucl Med 1993;34:666-70.
22. Markand ON, Salanova V, Worth R, Park H-M, Wellman HN. Comparative study of interictal PET and ictal SPECT in complex partial seizures. Acta Neurol Scand 1997;95:129-36.
23. 2O and positron emission tomography. Epilepsia 1996; 37:796-802.
24. Collins RC, Kennedy C, Sokoloff L, Plum F. Metabolic anatomy of focal seizures. Arch Neurol 1976;33:536-42.
25. 14C]deoxyglucose. Brain Res 1978;150:487-501.
26. Engel J Jr, Kuhl DE, Phelps ME, Rausch R, Nuwer M. Local cerebral metabolism during partial seizures. Neurology 1983;33: 400-13.
27. 15O and PET. Neurology 1995;45:1396-402.
28. Nehlig A, Vergnes M, Waydelich R, et al. Absence seizures induce a decrease in cerebral blood flow: human and animal data. J Cereb Blood Flow Metab 1996;16:147-55.
29. Matsumoto H, Ajmone Marsan C. Cortical cellular phenomena in experimental epilepsy: interictal manifestations. Exp Neurol 1964; 9:286-304.
30. Prince DA, Connors BW, Renardo LS. Mechanisms underlying interictal-ictal transitions. In: Delgado-Escueta AV, Wasterlain CG, Treiman DM, Porter RJ, eds. Advances in neurology, vol 34: status epilepticus. New York: Raven Press. 1983:177-87.
31. Matsumoto H, Ajmone Marsan C. Cortical cellular phenomena in experimental epilepsy: ictal manifestations. Exp Neurol 1964;9: 305-26.
32. Dichter MA, Ayala GF. Cellular mechanisms of epilepsy: a status report. Science 1987;237:157-64.
33. Knowlton RC, Laxer KD, Ende G, et al. Presurgical multimodality neuroimaging in electroencephalographic lateralized temporal lobe epilepsy. Ann Neurol 1997;42:829-37.
34. Henry TR, Engel J Jr, Mazziotta JC. Clinical evaluation of interictal fluorine-18-fluorodeoxyglucose PET in partial epilepsy. J Nucl Med 1993;34:1892-8.
35. Theodore WH, Sato S, Kufta CV, Gaillard WD, Kelley K, FDG-positron emission tomography and invasive EEG: seizure focus detection and surgical outcome. Epilepsia 1997;38:81-6.
36. Engel J, Brown WJ, Kuhl DE, Phelps ME, Mazziotta JC, Crandall PH. Pathological findings underlying focal temporal hypometabolism in partial epilepsy. Ann Neurol 1982;12:518-28.
37. Bernadi S, Trimble MR, Frackowiak RSJ, Wise RJS, Jones T. An interictal study of partial epilepsy using positron emission tomography and the oxygen-15 inhalation technique. J Neurol Neurosurg Psychiatry 1983;46:473-7.
38. Sloviter RS. The functional organization of the hippocampal dentate gyrus and its relevance to the pathogenesis of temporal lobe epilepsy. Ann Neurol 1994;35:640-54.
39. Gaillard WD, Fazilat S, White S, et al. Interictal metabolism and blood flow are uncoupled in temporal lobe cortex of patients with complex partial epilepsy. Neurology 1995;45:1841-7.
40. Fink GR, Pawlik G, Stefan H, Pietrzyk U, Wienhard K, Heiss WD. Temporal lobe epilepsy: evidence for interictal uncoupling of blood flow and glucose metabolism in temporomesial structures. J Neurol Sci 1996;137:28-34.
41. Cowan JMA, Rothwell JC, Wise RJS, Marsden CD. Electrophysiological and positron emission studies in a patient with cortical myoclonus, epilepsia partial is continua and motor epilepsy. J Neurol Neurosurg Psychiatry 1986;49:796-807.
42. Gloor P. Electroencephalography and the role of intracerebral depth electrode recordings in the selection of patients for surgical treatment of epilepsy. Adv Epileptol 1985;15:433-8.
43. Fox PT, Raichle ME. Focal physiological uncoupling of cerebral blood flow and oxidative metabolism during somatosensory stimulation in human subjects. Proc Natl Acad Sci USA 1986;83:1140-4.
44. DeYoe EA, Bandettini P, Neitz J, Miller D, Winans P. Functional magnetic resonance imaging (fMRI) of the human brain. Neurosci Methods 1994;54:171-87.
45. 2(15)O PET rCBF. J Cereb Blond Flow Metab 1996;16:755-64.
46. Clark VP, Keil K, Maisog JM, Courtney S, Ungerleider LG, Haxby JV. Functional magnetic resonance imaging of human visual cortex during face matching: a comparison with positron emission tomography. Neuroimage 1996;4:1-15.