Reduced seizure threshold and hippocampal cell loss in rats exposed to alcohol during the brain growth spurt

Alcoholism: Clinical and Experimental Research

Volumn 25, Issue 1, 2001, Pages 70-82

  Bonthius, Daniel J ^a   Woodhouse, Justin ^a   Bonthius, Nancy E ^b   Taggard, Derek A ^a   Lothman, Eric W ^c  

^a UNIVERSITY OF IOWA   (United States)

^b UNIVERSITY OF IOWA   (United States)

^c UNIVERSITY OF VIRGINIA   (United States)

Author keywords

Epilepsy; Fetal Alcohol Syndrome; Hippocampus; Pentylenetetrazol; Stereology

Indexed keywords

ALCOHOL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN DEVELOPMENT; BRAIN GROWTH; CELL COUNT; CELL LOSS; CONTROLLED STUDY; DOSE RESPONSE; FETAL ALCOHOL SYNDROME; GRANULE CELL; GROWTH ACCELERATION; HIPPOCAMPUS; MALE; NONHUMAN; PRIORITY JOURNAL; PYRAMIDAL NERVE CELL; RAT; SEIZURE THRESHOLD;

ANIMALIA; HIPPOCAMPUS HIPPOCAMPUS;

EID: 0035124672     PISSN: 01456008     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1530-0277.2001.tb02129.x     Document Type: Article

References (83)

1. Neurodevelopmental abnormalities: Behavioral and cognitive
2. Prenatal alcohol exposure attenuates pentylenetetrazol-induced convulsions in rats
3. Postnatal development of the cerebellar cortex in the rat. II. Phases in the maturation of Purkinje cells and of the molecular layer
4. A-benzodiazepine receptor number and pharmacology in the adult guinea pig cerebral cortex after chronic prenatal ethanol exposure
5. 3H-thymidine autoradiography
6. Audiogenic seizure susceptibility and auditory brainstem responses in rats prenatally exposed to alcohol
7. Commissural connections of the hippocampal region in the rat, with special reference to their mode of termination
8. Blood alcohol concentration and severity of microencephaly in neonatal rats depend on the pattern of alcohol administration
9. FAS and epilepsy: Exposure of the developing brain to alcohol alters features of maximal dentate gyms activation
10. Alcohol-induced neuronal loss in developing rats: Increased brain damage with binge exposure
11. Permanent neuronal deficits in rats exposed to alcohol during the brain growth spurt
12. Recurrent seizures and hippocampal sclerosis following intrahippocampal kainate injection in adult mice: Electroencephalography, histopathology and synaptic reorganization similar to mesial temporal lobe epilepsy
13. Medical risks for women who drink alcohol
14. Ontogenetic development of benzodiazepine receptors in the brain
15. Stage dependent effects of ethanol on cranial neural crest cell development: Partial basis for the phenotypic variations observed in fetal alcohol syndrome
16. Progressive neuronal loss induced by kindling: A possible mechanism for mossy fiber synaptic reorganization and hippocampal sclerosis
17. Effects of alcohol and nicotine on developing olfactory bulb: Loss of mitral cells and alterations in neurotransmitter levels
18. Audiogenic seizure susceptibility in mature rats with fetal alcohol syndrome
19. Critical periods for prenatal alcohol exposure: Evidence from animal and human studies
20. The later development of the brain and its vulnerability
21. Quantitative growth and development of human brain
22. Comparative aspects of the brain growth spurt
23. Evidence of enhanced kindling and hippocampal neuronal injury in immature rats with neuronal migration disorders
24. Activation of the dentate gyrus by pentylenetetrazol evoked seizures induces mossy fiber synaptic reorganization
25. Alcohol-induced Purkinje cell loss with a single binge exposure in neonatal rats: A stereological study of temporal windows of vulnerability
26. Neonatal binge ethanol exposure using intubation: Timing and dose effects on place learning
27. Temporal windows of vulnerability within the third trimester equivalent: Why "knowing when" matters
28. Binge neonatal alcohol intubations induce dose-dependent loss of Purkinje cells
29. Neonatal caffeine exposure alters seizure susceptibility in rats in an age-related manner
30. A quantitative evaluation of hippocampal neuronal loss in temporal lobe epilepsy without primary glial tumor
31. Notes on the estimation of the numerical density of arbitrary profiles: The edge effect
32. The efficiency of systematic sampling in stereology and its prediction
33. Epidemiology of epilepsy in children
34. Effects of ethanol on neuronal migration and neural cell adhesion molecules in the embryonic rat cerebral cortex: A tissue culture study
35. A receptors on medial septum/diagonal band (MS/DB) neurons after postnatal ethanol exposure
36. A receptor currents in Purkinje neurons
37. Ethanol-induced apoptotic neurodegeneration and fetal alcohol syndrome
38. Prediction of subsequent motor and mental retardation in newborn infants exposed to alcohol in utero by computerized EEG analysis
39. Fetal alcohol syndrome revisited
40. Children of substance abusers: Overview of research findings
41. Pattern of malformations in offspring of chronic alcoholic mothers
42. A receptors to allosteric modulatory drugs in rat hippocampus after chronic intermittent ethanol treatment
43. Neurobehavioral effects of prenatal alcohol exposure at 26 months
44. Developmental changes in alcohol pharmacokinetics in rats
45. Prenatal ethanol exposure: Susceptibility to convulsions and ethanol's anticonvulsant effect in amygdala-kindled rats
46. Experimental fetal alcohol syndrome: Proposed pathogenic basis for a variety of associated focal and brain anomalies
47. Patterns of ethanol-induced cell death in the developing nervous system of mice. Neural fold states through the time of anterior neural tube closure
48. Electrophysiology of hippocampal CA1 neurons after prenatal ethanol exposure
49. Pathophysiology of seizures and epilepsy in the mature and immature brain: Cells, synapses and circuits
50. A receptor α4-subunit expression: Possible relevance to alcohol dependence
51. Fetal alcohol exposure and temporal vulnerability: Regional differences in cell loss as a function of the timing of binge-like alcohol exposure during brain development
52. Alcohol embryopathy: Studies in Germany
53. Neurological findings in the fetal alcohol syndrome
54. Generation of neurons in the rat dentate gyrus and hippocampus: Effects of prenatal and postnatal treatment with ethanol
55. Epileptogenesis and the immature brain
56. Alcohol and fetal damage
57. Ethanol specifically potentates GABA-mediated neurotransmission in the feline cerebral cortex
58. Effects on the child of alcohol abuse during pregnancy
59. Fetal alcohol syndrome and seizure disorders
60. Prenatal exposure to ethanol retards the development of kindling in adult rats
61. Differential seizure sensitivities to picrotoxin in two inbred strains of mice: Parallel changes in GABA receptor-mediated chloride flux and receptor binding
62. Inherited convulsive disorders in mice
63. The epidemiology and treatment of chronic and refractory epilepsy
64. Follow-up studies of children with fetal alcohol syndrome
65. Convulsant potencies of tetrazoles are highly correlated with actions on GABA/benzodiazepine/picrotoxin receptor complexes in brain
66. Alcohol consumption during pregnancy among southern city women
67. The unbiased estimation of number and sizes of arbitrary particles using the disector
68. Attention: Prenatal alcohol and continuities of vigilance and attentional problems from 4 through 14 years
69. Intelligence, behavior and dysmorphogenesis in the fetal alcohol syndrome: A report on twenty cases
70. Pentylenetetrazol elicits epileptiform activity in the dentate gyrus of the urethane anesthetized rat by activation of the entorhinal cortex
71. Reverberatory seizure discharges in hippocampal-parahippocampal circuits
72. Bilateral maximal dentate activation is critical for the appearance of an afterdischarge in the dentate gyrus
73. Ethanol stimulates GABA receptor-mediated chloride transport in rat brain synaptoneurosomes
74. Alcohol-induced Purkinje cell loss depends on developmental timing of alcohol exposure and correlates with motor performance
75. Behavioral deficits induced by binge-like exposure to alcohol in neonatal rats: Importance of developmental timing and number of episodes
76. Systematic examination of the effects of alcohol on the total number of neurons in the rat hippocampal formation during different periods of development using unbiased stereology
77. Effects of alcohol exposure during different periods of development: Changes in hippocampal mossy fibers
78. Prenatal exposure to ethanol alters the organization of hippocampal mossy fibers in rats
79. Unbiased stereological estimation of the total number of neurons in the subdivisions of the rat hippocampus using the optical fractionator
80. Functional organization of the extrinsic and intrinsic circuitry of the parahippocampal region
81. The effect of alcohol consumed by parent mice on the susceptibility to audiogenic seizures and the open-field behavior of their offspring
82. Effects of aminergic drugs and glutamic acid on audiogenic seizures induced by early exposure to ethanol