Prevalence and conditions of selection of E44D/A and V118I human immunodeficiency virus type 1 reverse transcriptase mutations in clinical practice

Antimicrobial Agents and Chemotherapy

Volumn 45, Issue 3, 2001, Pages 946-948

  Delaugerre, C ^a   Mouroux, M ^a   Yvon Groussin, A ^a   Simon, A ^a   Angleraud, F ^a   Huraux, J M ^a   Agut, H ^a   Katlama, C ^a   Calvez, V ^a  

^a Department of Virology ^*  (France)

Author keywords

[No Author keywords available]

Indexed keywords

LAMIVUDINE; NUCLEOSIDE; RNA DIRECTED DNA POLYMERASE; ZIDOVUDINE;

AMINO ACID SUBSTITUTION; ARTICLE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; NONHUMAN; PHENOTYPE; PREVALENCE; PRIORITY JOURNAL; VIRUS GENOME; VIRUS MUTATION; VIRUS RESISTANCE;

ALANINE; AMINO ACID SUBSTITUTION; ANTI-HIV AGENTS; ASPARTIC ACID; DRUG RESISTANCE, MICROBIAL; GENE FREQUENCY; GLUTAMIC ACID; HIV INFECTIONS; HIV-1; HIV-1 REVERSE TRANSCRIPTASE; HUMANS; ISOLEUCINE; MUTATION; VALINE;

EID: 0035119501     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.45.3.946-948.2001     Document Type: Article

References (13)

1. High-level resistance to (-) enantiomeric 2′-deoxy-3′-thiacytidine in vitro is due to one amino acid substitution in the catalytic site of human immunodeficiency virus type 1 reverse transcriptase
2. Insertion of two amino acids combined with changes in reverse transcriptase containing tyrosine-215 of HIV-1 resistant to multiple nucleoside analogs
3. The K65R mutant reverse transcriptase of HIV-1 cross-resistant to 2′,3′-dideoxocytidine, 2′,3′-dideoxy-3′-thiacytidine, and 2′,3′-dideoxyinosine shows reduced sensitivity to specific dideoxynucleoside triphosphate inhibitors in vitro
4. Identification of a mutation at codon 65 in the IKKK motif of reverse transcriptase that encodes human immunodeficiency virus resistance to 2′,3′-dideoxycytidine and 2′,3′-dideoxy-3′-thiacytidine
5. A novel human immunodeficiency virus type 1 reverse transcriptase mutational pattern confers phenotypic lamivudine resistance in the absence of mutation 184V
6. Multidrug-resistant human immunodeficiency virus type 1 strains resulting from combination antiretroviral therapy
7. Mutations in retroviral genes associated with drug resistance
8. Multiple dideoxynucleoside analogue-resistant (MddNR) HIV-1 strains isolated from patients from different European countries
9. Rapid changes in human immunodeficiency virus type 1 RNA load and appearance of drug-resistant virus populations in persons treated with lamivudine (3TC)
10. Emergence of human immunodeficiency virus type 1 variants with resistance to multiple dideoxynucleosides in patients receiving therapy with dideoxynucleosides
11. Changes in drug sensitivity of human immunodeficiency virus type 1 during therapy with azidothymidine, dideoxycytidine, and dideoxyinosine: An in vitro comparative study
12. Rapid in vitro selection of human immunodeficieny virus type 1 resistant to 3′-thiacytidine inhibitors due to a mutation in the YMDD region of reverse transcriptase
13. A 6-basepair insert in the reverse transcriptase gene of human immunodeficiency virus type 1 confers resistance to multiple nucleoside inhibitors