Characteristics of the free cytosolic calcium timelag following IgE-mediated stimulation of human basophils: Significance for the nonreleasing basophil phenotype

Journal of Leukocyte Biology

Volumn 69, Issue 2, 2001, Pages 224-232

  MacGlashan Jr , Donald ^a   Lavens Phillips, Sandra ^a  

^a JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

Histamine release; Mediator release; Protein kinase C; Syk and lyn kinases

Indexed keywords

CALCIUM ION; GENISTEIN; HISTAMINE; IMMUNOGLOBULIN E; IMMUNOGLOBULIN E RECEPTOR; PROTEIN KINASE C; PROTEIN KINASE C INHIBITOR; PROTEIN TYROSINE KINASE; STAUROSPORINE;

ARTICLE; BASOPHIL; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; CELL STIMULATION; CYTOSOL; ENZYME ACTIVITY; ENZYME INHIBITION; HISTAMINE RELEASE; HUMAN; HUMAN CELL; LIGAND BINDING; PHENOTYPE; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; TIME;

ADULT; BASOPHILS; CALCIUM; CALCIUM SIGNALING; CELL SEPARATION; CYTOSOL; ENZYME ACTIVATION; ENZYME INHIBITORS; ENZYME PRECURSORS; HISTAMINE RELEASE; HUMANS; IMMUNOGLOBULIN E; IMMUNOPHENOTYPING; INTRACELLULAR FLUID; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; KINETICS; PHOSPHOPROTEIN PHOSPHATASE; PROTEIN-TYROSINE KINASES; PROTEINS; RECEPTORS, IGE; SRC-FAMILY KINASES;

TRIXIS;

EID: 0035116134     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (52)

1. Oscillations in free cytosolic calcium during IgE-mediated stimulation distinguish human basophils from human mast cells
2. Two roles of Ca2+ in agonist stimulated Ca2+ oscillations
3. A single-pool inositol 1,4,5-trisphosphate-receptor-based model for agonist-stimulated oscillations in Ca2+ concentration
4. Effect of Ca2+ influx on intracellular free Ca2+ responses in antigen-stimulated RBL-2H3 cells
5. A comparative study of releasing and nonreleasing human basophils: Nonreleasing basophils lack an early component of the signal transduction pathway that follows IgE cross-linking
6. Intracellular events in anti-IgE nonreleasing human basophils
7. Syk deficiency in nonreleaser basophils
8. The tyrosine kinases p53/56lyn and p72syk are differentially expressed at the protein level but not at the mRNA level in non-releasing human basophils
9. Differential control of the tyrosine kinases lyn and syk by the two signaling chains of the high affinity immunoglobulin E receptor
10. Aggregation of the high-affinity IgE receptor and enhanced activity of p53/56lyn protein-tyrosine kinase
11. Biochemical evidence that the phosphorylated tyrosines, serines, and threonines on the aggregated high affinity receptor for IgE are in the immunoreceptor tyrosine-based activation motifs
12. Characterization of protein-tyrosine phosphatases that dephosphorylate the high affinity IgE receptor
13. Shuttling of initiating kinase between discrete aggregates of the high affinity receptor for IgE regulates the cellular response
14. Protein tyrosine phosphorylation in the degranulation step of RBL-2H3 cells
15. Fc epsilon RI-induced protein tyrosine phosphorylation of pp72 in rat basophilic leukemia cells (RBL-2H3). Evidence for a novel signal transduction pathway unrelated to G protein activation and phosphatidylinositol hydrolysis
16. Src homology, 2 domains of syk and lyn bind to tyrosine-phosphorylated subunits of the high affinity IgE receptor
17. Src family tyrosine kinase p53/56lyn, a serine kinase and Fc epsilon RI associate with alpha-galactosyl derivatives of ganglioside GD1b in rat basophilic leukemia RBL-2H3 cells
18. Fc epsilon RI-mediated tyrosine phosphorylation and activation of the 72kDa protein-tyrosine kinase, PTK72, in RBL-2H3 rat tumor mast cells
19. Studies of antigen binding on human basophils. II. Continued expression of antigen-specific IgE during antigen-induced desensitization
20. Secretion of interleukin-4 from human basophils: The relationship between IL-4 mRNA and protein in resting and stimulated basophils
21. Basophil counting with a new staining method using alcian blue
22. An automated continuous-flow system for the extraction and fluorometric analysis of histamine
23. Studies of antigen binding on human basophils. I. Antigen binding and functional consequences
24. Interleukin-3 alters free arachidonic acid generation in C5a-stimulated human basophils
25. Regulation of store-operated calcium currents in mast cells
26. Single-cell analysis of Ca++ changes in human lung mast cells: Graded vs. all-or-nothing elevations after IgE-mediated stimulation
27. Histamine release due to bivalent penicilloyl haptens: Control by the number of cross-linked IgE antibodies on the basophil plasma membrane
28. Theory of equilibrium binding of symmetric bivalent haptens to cell surface antibody: Application to histamine release from basophils
29. Qualitative differences between dimeric and trimeric stimulation of human basophils
30. Characteristics of human basophil sulfidopeptide leukotriene release: Releasability defined as the ability of the basophil to respond to dimeric cross-links
31. An unusual mechanism for ligand antagonism
32. The src family-selective tyrosine kinase inhibitor PP1 blocks LPS and IFN-gamma-mediated TNF and iNOS production in murine macrophages
33. Src family-selective tyrosine kinase inhibitor, PP1, inhibits both Fc epsilonRI- and Thy-1-mediated activation of rat basophilic leukemia cells
34. Pharmacology of IgE-mediated desensitization of human basophils: Effects of protein kinase C and Src-family kinase inhibitors
35. Signal transduction events in human basophils. A comparative study of the role of protein kinase-C in basophils activated by anti-IgE antibody and formyl-methionyl-leucylphenylalanine
36. Role of tyrosine kinases in IgE-mediated signal transduction in human lung mast cells and basophils
37. Expression of protein kinase C isozymes in human basophils: Regulation by physiological and non-physiological stimuli
38. Effect of cAMP-elevating drugs on stimulus-induced cytosolic calcium changes in human basophils
39. Phosphatidylinositol-3 kinase regulates p21ras activation during IgE-mediated stimulation of human basophils
40. Biphasic Ca++ responses in human basophils: Evidence that the initial transient elevation associated with mobilization of intracellular calcium is an insufficient signal for degranulation
41. Antigen-specific desensitization of human basophils
42. Regulation of secretion from secretory cells by protein kinase C
43. Functional effects of overexpression of protein kinase C-α, -β, -δ, -ε, -η in the mast cell line RBL-2H3
44. Protein kinases C-beta and C-epsilon link the mast cell high affinity receptor for IgE to the expression of c-fos and c-jun
45. Differences in phosphorylation of formylpeptide and C5a receptors correlate with differences in desensitization
46. Evidence of an important and direct role for protein kinase C in agonist-induced phosphorylation leading to desensitization of the angiotensin AT1A receptor
47. Btk/Tec kinases regulate sustained increases in intraeellular Ca2+ following B-cell receptor activation
48. PtdIns-3,4,5-P3: A regulatory nexus between tyrosine kinases and sustained calcium signals
49. Differential activation of human basophils by anti-IgE and formylmethionyl-leucyl-phenylalanine. Indications for protein kinase C-dependent and -independent activation pathways
50. Inhibitors of PI 3-kinase and MEK kinase differentially affect mediator secretion from immunologically activated human basophils
51. Multiple roles for PI 3-kinase in the regulation of PLCgamma activity and Ca2+ mobilization in antigen-stimulated mast cells