Keratinocyte CDw60 expression is modulated by both a Th-1 type cytokine IFN-γ and Th-2 cytokines IL-4 and IL-13: Relevance to psoriasis

Journal of Investigative Dermatology

Volumn 116, Issue 2, 2001, Pages 305-312

  Huang, Barbara ^a   Bonish, Brian K ^a   Chaturvedi, Vijaya ^a   Qin, Jian Zhong ^a   Nickoloff, Brian J ^a  

^a LOYOLA UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

BCL 6; Ganglioside; Immunocyte; STAT1; STAT6

Indexed keywords

CD6 ANTIGEN; CD60 ANTIGEN; GAMMA INTERFERON; GANGLIOSIDE GD3; HLA DR ANTIGEN; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 13; INTERLEUKIN 4; PROTEIN BCL 6; STAT1 PROTEIN; STAT6 PROTEIN; UNCLASSIFIED DRUG;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN EXPRESSION; ARTICLE; CELL INTERACTION; CLINICAL ARTICLE; CONTROLLED STUDY; HUMAN; HUMAN TISSUE; KERATINOCYTE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN INDUCTION; PROTEIN LOCALIZATION; PSORIASIS; T LYMPHOCYTE; TH1 CELL;

EID: 0035115999     PISSN: 0022202X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1523-1747.2001.01242.x     Document Type: Article

References (38)

1. Interleukin 10 treatment of psoriasis: Clinical results of a phase 2 trial
2. UM4D4+ (CDw60) T cells are compartmentalized into psoriatic skin and release lymphokines that induce a keratinocyte phenotype expressed in psoriatic lesions
3. Increased epidermal cell proliferation in normal human skin in vivo following local administration of interferon-γ
4. Pulling the trigger in psoriasis
5. The pathogenesis of psoriasis: Immunological facts and speculations
6. Expression of CD60 on multiple cell lineages in inflammatory synovitis
7. Skin-infiltrating lymphocytes in normal and disordered skin: Activation signals and functional roles in psoriasis and mycosis fungoides-type cutaneous T cell lymphoma
8. BCL-6-deficient mice reveal an IL-4-independent, STAT6-dependent pathway that controls susceptibility to infection by Leishmania major
9. Inhibition of IL-4-inducible gene expression in human monocytes by type I and type II interferons
10. Psoriasis induced at the injection site of recombinant interferon gamma: Results of immunohistologic investigations
11. Activation pathways of synovial T lymphocytes. Expression and function of the UM4D4/CDw60 antigen
12. T-lymphocyte dependence of psoriatic pathology in human psoriatic skin grafted to SCID mice
13. Immunopathogenesis of psoriasis
14. Response of psoriasis to a lymphocyte-selective toxin (DAB389IL-2) suggests a primary immune, but not keratinocyte, pathogenic basis
15. Transcriptional repression of Stat6-dependent interleukin-4-induced genes by BCL-6: Specific regulation of epsilon transcription and immunoglobulin E switching
16. Differential involvement of Th1 and Th2 cytokines in autoimmune diseases
17. An epithelial cell line that can stimulate alloproliferation of resting CD4+ T cells, but not after IFN-gamma stimulation
18. The cytokine network in psoriasis
19. The immunologic and genetic basis of psoriasis
20. Creation of psoriatic plaques: The ultimate tumor suppressor pathway
21. Keratinocyte interleukin-10 expression is upregulated in tape-stripped skin, poison ivy dermatitis, and Sezary syndrome, but not in psoriatic plaques
22. Severe combined immunodeficiency mouse and human psoriatic skin chimeras. Validation of a new animal model
23. Response of murine and normal human skin to injection of allogeneic blood-derived psoriatic immunocytes: Detection of T cells expressing receptors typically present on natural killer cells, including CD94, CD158, and CD161
24. Characterization of a T cell line bearing natural killer receptors and capable of creating psoriasis in a SCID mouse model system
25. BCL-6 gene product, a 92- to 98-kD nuclear phosphoprotein, is highly expressed in germinal center B cells and their neoplastic counterparts
26. M3 inhibits the proliferation of cultured keratinocytes
27. Ganglioside GT1b induces keratinocyte differentiation without activating protein kinase C
28. IL-4 and IL-13 activate the JAK2 tyrosine kinase and Stat6 in cultured human vascular endothelial cells through a common pathway that does not involve the gamma c chain
29. Two distinct gamma interferon-inducible promoters of the major histocompatibility complex class II transactivator gene are differentially regulated by STAT1, interferon regulatory factor 1, and transforming growth factor beta
30. T cells involved in psoriasis vulgaris belong to the Th1 subset
31. Lesional psoriatic T cells contain the capacity to induce a T cell activation molecule CDw60 on normal keratinocytes
32. Keratinocyte activation following T-lymphocyte binding
33. Two gamma-interferon-activation sites (GAS) on the promoter of the human intercellular adhesion molecule (ICAM-1) gene are required for induction of transcription by IFN-gamma
34. The cytokine network in lesional and lesion-free psoriatic skin is characterized by a T-helper type 1 cell-mediated response
35. Psoriasis: A disease of abnormal keratinocyte proliferation induced by T lymphocytes
36. The 9-O-acetylated disialosyl carbohydrate sequence of CDw60 is a marker on activated human B lymphocytes
37. Discordant expression of Bcl-x and Bcl-2 by keratinocytes in vitro and psoriatic keratinocytes in vivo
38. Repeated subcutaneous injection of staphylococcal enterotoxin B-stimulated lymphocytes retain epidermal thickness of psoriatic skin-graft onto severe combined immunodeficient mice