Antibodies against full-length Tat protein and some low-molecular-weight Tat-peptides correlate with low or undetectable viral load in HIV-1 seropositive patients

Journal of Clinical Virology

Volumn 21, Issue 1, 2001, Pages 81-89

  Re, M C ^a   Vignoli, M ^a   Furlini, G ^a   Gibellini, D ^a   Colangeli, V ^a   Vitone, F ^a   La Placa, M ^a  

^a UNIVERSITY OF BOLOGNA   (Italy)

Author keywords

Anti Tat antibody; HV 1 viral load; Tat protein

Indexed keywords

ANTIBODY; IMMUNOGLOBULIN G ANTIBODY; PEPTIDE; PROTEIN ANTIBODY; RNA DIRECTED DNA POLYMERASE INHIBITOR; TRANSACTIVATOR PROTEIN;

ADULT; ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; HUMORAL IMMUNITY; IMMUNE RESPONSE; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; VIRUS LOAD;

ADULT; ANTI-HIV AGENTS; FEMALE; GENE PRODUCTS, TAT; HIV ANTIBODIES; HIV INFECTIONS; HIV SEROPOSITIVITY; HIV-1; HUMANS; IMMUNOENZYME TECHNIQUES; IMMUNOGLOBULIN G; MALE; PEPTIDE FRAGMENTS; RNA, VIRAL; VIRAL LOAD;

EID: 0035114575     PISSN: 13866532     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1386-6532(00)00189-X     Document Type: Article

References (43)

1. The angiogenesis induced by HIV-1 Tat protein is mediated by the Flk-1/KDR receptor on vascular endothelial cells
2. Identification of a novel domain of HIV tat involved in monocyte chemotaxis
3. Monocyte-derived dendritic cells and monocytes migrate to HIV-Tat RGD and basic peptides
4. Extracellular HIV-1 Tat protein activates phosphatidylinositol 3- and Akt/PKB kinases in CD4+ T lymphoblastoid Jurkat cells
5. Control of SHIV-89.6P-infection of cynomolgus monkeys by HIV-1 Tat protein vaccine
6. Multiple functions of human immunodeficiency virus type 1 Tat protein in the pathogenesis of AIDS
7. Pronounced acute immunosuppression in vivo mediated by HIV Tat challenge
8. Extracellular human immunodeficiency virus type 1 Tat protein is associated with an increase in both NF-kappa B binding and protein kinase C activity in primary human astrocytes
9. Detection of distinct patterns of anti-tat antibodies in HIV-infected individuals with or without Kaposi's sarcoma
10. Release uptake and effects of extracellular human immunodeficiency virus type 1 Tat protein on cell growth and viral transactivation
11. HIV-1, fifteen proteins and an RNA
12. Tat as one key to HIV-induced immune pathogenesis and Tat toxoid as an important component of a vaccine
13. Upregulation of c-Fos in activated T lymphoid and monocytic cells by human immunodeficiency virus-1 Tat protein
14. Extracellular HIV-1 Tat protein induces the rapid Ser133 phosphorylation and activation of CREB transcription factor in both Jurkat lymphoblastoid T cells and primary peripheral blood mononuclear cells
15. Extracellular HIV-1 Tat protein activates the transcriptional reprossor ICER in both Jurkat cell line and primary peripheral blood mononuclear cells
16. Safety and immunogenicity of HIV-1 Tat toxoid in immunocompromised HIV-1-infected patients
17. Tat toxoid as a component of a preventive vaccine in seronegative subjects
18. Control of RNA initiation and elongation at the HIV-1 promoter
19. HIV-1 Tat transcriptional activity is regulated by acetylation
20. HIV-Tat protein activates c-Jun N-terminal kinase and activator protein-1
21. HIV-1-Tat protein promotes chemotaxis and invasive behavior by monocytes
22. prophylactic and therapeutic AIDS vaccine containing as a component the innocuous Tat toxoid
23. Induction of apoptosis in uninfected lymphocytes by HIV-1 Tat protein
24. Dual role of HIV Tat in regulation of apoptosis in T cells
25. HIV-1 tat transactivator recruits p300 and CREB-binding protein histone acetyltransferases to the viral promoter
26. Temporal fluctuations in HIV quasispecies in vivo are not reflected by sequential HIV isolations
27. HIV-1 Tat induces tyrosine phosphorylation of p125FAK and its association with phosphoinositide 3-kinase in PC12 cells
28. Tat-human immunodeficiency virus-1 induces human monocyte chemotaxis by activation of vascular endothelial growth factor receptor-1
29. Acetylation of the HIV-1 Tat protein by p300 is important for its transcriptional activity
30. Enhanced nuclear factor-kappa B activation induced by tumour necrosis factor-alpha in stably tat-transfected cells is associated with the presence of cell-surface-bound Tat protein
31. Effect of antibody to HIV-1 Tat protein on viral replication in vitro and progression of HIV-1 disease in vivo
32. Antibody against human immunodeficiency virus type 1 (HIV-1) Tat protein may have influenced the progression of AIDS in HIV-1-infected hemophiliac patients
33. Viral load trend in HIV-1 seropositive patients with different CD4 cell count before strarting HAART
34. HIV-I Tat, a polypeptide for all seasons
35. Antibody to HIV-1 Tat protein inhibits the replication of virus in culture
36. Activation of Bcl-2 promoter-directed gene expression by the human immunodeficiency virus type-1 Tat protein
37. Sensitization of T cells to CD95-mediated apoptosis by HIV-1 Tat and gp120
38. Antibodies to the HIV-1 Tat protein correlated with nonprogression to AIDS a rationale for the use of Tat toxoid as an HIV-1 vaccine
39. Human immunodeficiency virus type 1 Tat protein protects lymphoid epithelial and neuronal cell lines from death by apoptosis
40. An autocrine loop of HIV type-1 Tat protein responsible for the improved survival/proliferation capacity of permanently Tat-transfected cells and required for optimal HIV-1 LTR transactivating activity
41. The human immunodeficiency virus type-1 Tat protein upregulates Bcl-2 gene expression in Jurkat T-cell lines and primary peripheral blood mononuclear cells
42. Pleiotropic effects of immobilized versus soluble recombinant HIV-1 Tat protein on CD3-mediated activation induction of apoptosis and HIV-1 long terminal repeat transactivation in purified CD4+ T lymphocytes