50S ribosomal subunit synthesis and translation are equivalent targets for erythromycin inhibition in Staphylococcus aureus

Antimicrobial Agents and Chemotherapy

Volumn 40, Issue 5, 1996, Pages 1301-1303

  Champney, W Scott ^a   Burdine, Robin ^a  

^a East Tennessee State University   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ERYTHROMYCIN;

ANTIBACTERIAL ACTIVITY; ARTICLE; BACTERIAL GROWTH; DOSE RESPONSE; DRUG PROTEIN BINDING; GROWTH INHIBITION; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PRIORITY JOURNAL; RIBOSOME SUBUNIT; STAPHYLOCOCCUS AUREUS; TRANSLATION REGULATION;

EID: 0029991408     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/aac.40.5.1301     Document Type: Article

References (11)

1. Champney, W. S. Unpublished data.
2. Champney, W. S., and R. Burdine. 1995. Macrolide antibiotics inhibit 50S ribosomal subunit assembly in Bacillus subtdis and Staphylcoccus aureus. Antimicrobial Agents Chemother. 39:2141-2144.
3. Chittum, H. S., and W. S. Champney. 1945 Erythromycin inhibits the assembly of the large ribosomal subunit in growing Escherichia coli cells Curi. Microbiol. 30:273-279.
4. Corcoran, J. W. 1984. Mode of action and resistance mechanisms of macrolides, p. 231-259. In S. Omura (ed.), Macrolide antibiotics. Academic Press, Inc., Orlando, Fla.
5. Cundliffe, E. 1987. On the nature of antibiotic binding sites in ribosomes Biochimie 69:863-869.
6. Cundliffe, E. 1990 Recognition sites for antibiotics within rRNA, p. 479-490. In W. E. Hill, A. Dahlberg, R A Garrett, P. B. Moore, D. Schlessinger, and J. R. Warner (ed.). The ribosome. structure, function and evolution. American Society for Microbiology, Washington, D.C.
7. Dodd, J., J. M. Kolb, and M. Nomura. 1991. Lack of complete cooperativity of ribosomal assembly in vitro and its possible relevance to in vivo assembly and the regulation of ribosomal gene expression. Biochimie 73:757-767.
8. Miller, J. H. 1972 Experiments in molecular genetics. Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y.
9. Nakayama, I. 1984 Macrolides in clinical practice. p. 261-300 In S. Omura (ed ), Macrolide antibiotics. Academic Press, Inc , Orlando, Fla.
10. Osawa, S., E. Otaka, T. Itoh, and T. Fukui. 1969 Biosynthesis of 50s ribosomal subunit in Escherichia coli. J. Mol. Biol 40:321-351.
11. Vazquez, D. 1979. Inhibitors of protein biosynthesis. Springer-Verlag, Berlin