High density O-glycosylation of the MUC2 tandem repeat unit by N-acetylgalactosaminyltransferase-3 in colonic adenocarcinoma extracts

Cancer Research

Volumn 61, Issue 3, 2001, Pages 950-956

  Inoue, Mizue ^a   Takahashi, Shuji ^a   Yamashina, Ikuo ^a   Kaibori, Masaki ^b   Okumura, Tadayoshi ^b   Kamiyama, Yasuo ^b   Viehier Guerre, Sophie ^c   Cantacuzène, Daniéle ^c   Nakada, Hiroshi ^a  

^a KYOTO SANGYO UNIVERSITY   (Japan)

^b KANSAI MEDICAL UNIVERSITY   (Japan)

^c INSTITUT PASTEUR   (France)

Author keywords

[No Author keywords available]

Indexed keywords

MESSENGER RNA; MUCIN 2; MUCIN LIKE CARCINOMA ASSOCIATED ANTIGEN; N ACETYLGALACTOSAMINYLTRANSFERASE; N ACETYLGALACTOSAMINYLTRANSFERASE 1; N ACETYLGALACTOSAMINYLTRANSFERASE 2; N ACETYLGALACTOSAMINYLTRANSFERASE 3; UNCLASSIFIED DRUG; URIDINE DIPHOSPHATE N ACETYLGALACTOSAMINE;

COLON ADENOCARCINOMA; CONTROLLED STUDY; ENZYME ACTIVE SITE; ENZYME GLYCOSYLATION; ENZYME SPECIFICITY; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN GLYCOSYLATION; PROTEIN PROTEIN INTERACTION; REVIEW; TANDEM REPEAT;

ACETYLGALACTOSAMINE; ADENOCARCINOMA; ANTIGENS, TUMOR-ASSOCIATED, CARBOHYDRATE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; COLONIC NEOPLASMS; GLYCOSYLATION; HUMANS; INDICATORS AND REAGENTS; INTESTINAL MUCOSA; ISOENZYMES; ISOTHIOCYANATES; MUCINS; N-ACETYLGALACTOSAMINYLTRANSFERASES; P-DIMETHYLAMINOAZOBENZENE; RNA, MESSENGER; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; TANDEM REPEAT SEQUENCES; TISSUE EXTRACTS;

EID: 0035110785     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (34)

1. Oligosaccharide differences in the DF3 sialomucin antigen from normal human milk and the BT-20 human breast carcinoma cell line
2. Carbohydrate antigens on cancer-associated mucin-like molecules
3. Elucidation of an essential structure recognized by an anti-GalNAcα-Ser(Thr) monoclonal antibody (MLS 128)
4. Epitopic structure of Tn glycophorin A for an anti-Tn antibody (MLS 128)
5. Tn antigen is expressed on leukosialin from T-lymphoid cells
6. Binding characteristics of an anti-Siaα2-6GalNAcα-Ser/Thr (sialyl Tn) monoclonal antibody (MLS 132)
7. Immunization of breast cancer patients using a synthetic sialyl-Tn glycoconjugate plus Detox adjuvant
8. A fully synthetic immunogen carrying a carcinoma-associated carbohydrate for active specific immunotherapy
9. Glycosylation of the tandem repeat unit of the MUC2 polypepfide leading to the synthesis of the Tn antigen
10. Mucin glycoproteins in neoplasia
11. Glycoprotein biosynthesis: The purification and characterization of a polypeptide: N-acetylgalactosaminyltransferase from bovine submaxillary glands
12. Purification and characterization of UDP-GalNAc:polypeptide N-acetylgalactosamine transferase from an ascites hepatoma, AH 66
13. A family of UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferases control the initiation of mucin-type O-linked glycosylation
14. Molecular cloning of human intestinal mucin cDNAs. Sequence analysis and evidence for genetic polymorphism
15. Short synthetic glycopeptides successfully induce antibody responses to carcinoma-associated Tn antigen
16. Isolation and characterization of polypeptide at the picomole level. Pre-colunm formation of peptide derivatives with dimethylaminoazobenzene isothiocyanate
17. Cleavage of sperm whale myoglobin with cyanogen bromide
18. Determination of the site-specific O-glycosylation pattern of the porcine submaxillary mucin tandem repeat glycopeptide
19. Isolation and expression of a cDNA clone encoding a bovine UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase
20. Purification, cloning, and expression of a bovine UDP-GalNAc:polypeptide N-acetyl-galactosaminyltransferase
21. Purification and cDNA cloning of a human UDP-N-acetyl-α-D-galactosamine: Polypeptide N-acetylgalactosaminyltransferase
22. cDNA cloning and expression of a novel human UDP-N-acetyl-α-D-galactosamine
23. Specific, major histocompatibility complex-unrestricted recognition of tumor associated mucins by human cytotoxic T cells
24. Structure and biology of a carcinoma-associated mucin, MUC1
25. High density O-glycosylation on tandem repeat peptide from secretory MUCI of T47D breast cancer cells
26. Cloning of a human UDP-N-acetyl-α-Dgalactosamine:polypeptide N-acetylgalactosaminyltransferase that complements other GalNAc-transferases in complete O-glycosylation of the MUC2 tandem repeat
27. Isolation and characterization of colon cancer mucin from xenografts of LS 174T cells
28. Expression of Tn, sialosyl-Tn, and T antigens in human colon cancer
29. Expression of three UDP-N-acetyl-α-D-galactosamine:polypeptide N-acetylgalactosaminyltransferases in adenocarcinoma cell lines
30. Substrate specificities of three members of the human UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase family, GalNAc-T-T2, and -T3
31. Influence of acceptor substrate primary amino acid sequence on the activity of human UDP-N-acetylgalactosamine:polypeptide N-acetylgalactosaminyltransferase
32. Incorporation of N-acetylgalactosamine into consecutive threonine residues in MUC2 tandem repeat by recombinant human N-acetyl-D-galactosamine transferase-T1, T2 and T3
33. Dynamic epigenic regulation of initial O-glycosylation by UDP-N-acetylgalactosamine:polypeptide N-acetylgalactosaminyltransferases
34. Cloning and characterization of a close homologue of human UDP-N-acetyl-α D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-T3 designated GalNAc-T6