Particulate-induced, prostaglandin- and cytokine-mediated bone resorption in an experimental system and in failed joint replacements

American Journal of Therapeutics

Volumn 3, Issue 1, 1996, Pages 27-41

  Glant, Tibor T ^a,b   Jacobs, Joshua J ^a   Mikecz, Katalin ^a   Yao, Jianling ^a   Chubinskaja, Susan ^a   Williams, James M ^a   Urban, Robert L ^a   Shanbhag, Arun S ^a   Lee, Soo Ho ^a   Sumner, Dale R ^a  

^a RUSH MEDICAL COLLEGE   (United States)

^b RUSH UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

bone resorption; fibroblasts; gene expression; IL 1; IL 6; in situ hybridization; interfacial membrane; macrophages; metalloproteinases; misoprostol; organ culture; particulate wear debris; prostaglandin; quantitative polymerase chain reaction; TIMP; TNF ; total hip arthroplasty

Indexed keywords

INDOMETACIN; INTERLEUKIN 1; INTERLEUKIN 6; METALLOPROTEINASE; MISOPROSTOL; PROSTAGLANDIN E2; TITANIUM; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BONE ATROPHY; CELL AGGREGATION; COXITIS; DRUG EFFECT; ENZYME REGULATION; ENZYME SYNTHESIS; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOPATHOGENESIS; MACROPHAGE ACTIVATION; MOUSE; NONHUMAN; OSTEOLYSIS; POSTOPERATIVE COMPLICATION; PRIORITY JOURNAL; TOTAL HIP PROSTHESIS;

EID: 0030030809     PISSN: 10752765     EISSN: None     Source Type: Journal    
DOI: 10.1097/00045391-199601000-00006     Document Type: Article

References (82)

1. Goodman SB, Chin RC, Chiou SS, Schurman DJ, Woolson ST, Masada MP: A clinical-pathologic-biochemical study of the membrane surrounding loosened and non-loosened total hip arthroplasties. Clin Orthop 1989;244: 182-187.
2. Dorr LD, Bloebaum R, Emmanual J, Meldrum R: Histologic, biochemical and ion analysis of tissue and fluids retrieved during total hip arthroplasty. Clin Orthop 1990;261:82-95.
3. Gowen M: Interleukin 1 and tumor necrosis factor. In: Cytokines and Bone Metabolism (Ed. Gowen M), CRC Press, Boca Raton, FL, 1992, pp. 71-91.
4. Goldring SR, Goldring MB: Prospects for pharmacological intervention. In: Cytokines and Bone Metabolism. (Ed. Gowen M), CRC Press, Boca Raton, FL, 1992, pp. 383-406.
5. Glant TT, Jacobs JJ, Molnár G, Shanbhag AS, Valyon M, Galante JO: Bone resorption activity of particulate-stimulated macrophages. J Bone Miner Res 1993;8:1071-1079.
6. Ellis JS, Chain BM, Cooke A, Ibrahim MA, Katz DR: Adjuvant composition determines the induction of type II collagen-induced arthritis. Scand J Immunol 1992;36: 49-56.
7. Jones LC, Hungerford DS: Cement disease. Clin Orthop 1987;225:192-206.
8. Shanbhag AS, Jacobs JJ, Black J, Galante JO, Glant TT: Cellular mediators secreted by interfacial membranes obtained at revision total hip arthroplasties. J Arthoplas 1994;9 (in press).
9. Glant TT, Valyon M, Dellacqua D, Walcz E, Mikecz K, Chubinskaja S, Jacobs JJ, Rosenberg A, Gitelis S, Sheinkop M, Galante JO: Quantitative measurement of genes coding for "bone-resorbing" cytokines in periprosthetic inflammatory tissues of failed total hip arthroplasties. Trans ORS 1994;19:152.
10. Glant TT, Mikecz K, Cole A, Bittar T, Lark MW, Sandell L, Jacobs JJ, Kuettner KE: In situ localization of metalloproteinases and TIMP in interfacial membranes of loosened total hip arthroplasties. Trans ORS 1994;19:138.
11. Glant TT, Jacobs JJ: The response of three murine macrophage populations to particulate debris: bone resorption in organ cultures. J Orthop Res 1994;12:720-731.
12. Goldring SR, Schiller AL, Roelke M, Rourke CM, O'Neill DA, Harris WH: The synovial-like membrane at the bone-cement interface in loose total hip replacements and its proposed role in bone lysis. J Bone Joint Surg 1983;65A:575-584.
13. Goldring SR, Jasty M, Roelke MS, Rourke CM, Bringhurst FR, Harris WH: Formation of a synovial-like membrane at the bone-cement interface. Its role in bone resorption and implant loosening after total hip replacement. Arthritis Rheum 1986;29:836-841.
14. Harvey W: Inflammation, cytokines, and prostaglandins. In: Prostaglandins in Bone Resorption, CRC Press, Boca Raton, FL, 1988, pp. 57-72.
15. Molnár G, Jacobs JJ, Erhardt P, Urban RM, Glant TT, Galante JO: Particulate titanium induced bone resorption in organ culture. Trans ORS 1991;15:540.
16. Shanbhag AS, Glant TT, Jacobs JJ, Black J: Macrophage release of inflammatory mediators is affected by size, composition and surface area of phagocytosable particles. Orthop Trans 1992;16:487-488.
17. Glant TT, Jacobs JJ, Tabith K, Sumner DR, Galante JO: Particulate-induced bone resorption in organ culture. Trans ORS 1992;16:398.
18. Shanbhag AS, Jacobs JJ, Black J, Glant TT: Cellular mediators secreted by interfacial membrane adjacent to hip prosthesis. FASEB J 1992;6:A1333.
19. Shanbhag AS, Glant TT, Gilbert JL, Black J, Galante JO: Chemical and morphological characterization of wear debris in failed uncemented total hip replacement. Trans ORS 1993,18:196.
20. Shanbhag AS, Jacobs JJ, Black J, Glant TT: Pro- and anti-inflammatory mediators secreted by cells of interfacial membranes from revision total hip replacements. Trans ORS 1993;18:517.
21. Shanbhag AS, Black J, Jacobs JJ, Galante JO, Glant TT: Surface area as a parameter to study macrophage response to particulate biomaterials. Trans Soc Biomat 1993;16:241.
22. Jacobs JJ, Shanbhag AS, Black J, Glant T, Galante JO: Osteolysis: cell, tissue and organ culture studies. Trans ORS 1993;17:582.
23. Jacobs JJ, Glant TT, Gilbert JL, Galante JO: Recovery and microchemical characterization of wear particles from failed uncemented total hip arthroplasty. Trans Soc Biomat 1993;16:241.
24. Shanbhag AS, Jacobs JJ, Glant TT, Gilbert JL, Black J, Galante JO: Characterization of polyethylene and other wear debris in failed uncemented total hip replacement. Orthop Trans 1993;17:716-717.
25. Shanbhag AS, Jacobs JJ, Black J, Galante JO, Glant TT: Inflammatory mediators secreted by cells of interfacial membranes from revision total hip replacements. Orthop Trans 1993;17:796.
26. Shanbhag AS, Jacobs JJ, Black J, Galante JO, Glant TT: Macrophage/particle interactions. Effect of size, composition and surface area. J Biomed Mater Res 1994;28: 81-90.
27. Shanbhag AS, Jacobs JJ, Glant TT, Gilbert JL, Black J, Galante JO: Composition and morphology of wear debris in failed uncemented total hip replacement arthroplasty. J Bone Joint Surg 1994;76B:60-67.
28. Shanbhag AS, Black J, Jacobs JJ, Galante JO, Glant TT: Human monocyte response to submicron fabricated and retrieved polyethylene, TI-6AL-4V and Ti particles. Trans ORS 1994;19.
29. Yao J, Glant TT, Hutchinson N, Kuettner KE: Gene regulation of collagenase, stromelysin, TIMP and collagens in synovial fibroblasts exposed to titanium particulates. Trans ORS 1994;19:260.
30. Shanbhag A, Black J, Jacobs JJ, Galante JO, Glant TT: Human monocyte response to submicron titanium-6% aluminum-4% vandium, titanium and polyethylene particles. Trans Soc Biomat 1994;17:79.
31. Shanbhag AS, Jacobs JJ, Glant TT, Talbert LF, Leigh HD, Black J: Submicron particulate polyethylene and titanium-alloy stimulated bone resorptive and fibroblast stimulatory activity. Trans Soc Biomat 1994;17:242.
32. Jacobs JJ, Shanbhag A, Glant TT, Black J, Galante JO: Wear debris in total joints. J Am Acad Orthop Surg 1994; 2:212-220.
33. Shanbhag AS, Jacobs JJ, Black J, Galante JO, Glant TT: Human monocyte response to particulate wear debris generated in vivo and in vitro. J Orthop Res 1995 (In press).
34. Glant TT, Valyon M, Mikecz K, Cole A, Jacobs JJ, Yao J, Kuettner KE: Discoordinate expression of IL-1α and IL-1β in interfacial membranes of failed joint prosthesis. Agents Actions 1994;41:C172-C173.
35. Glant TT, Jacobs JJ: Experimental models of osteolysis. Assays for bone resorbing cytokines and metalloproteinases. In: Total Hip Revision Surgery (Eds. Galante JO, Rosenberg A), Hogrefe & Huber, Gottingen, 1994 Raven Press, New York, pp. 127-136.
36. Shanbhag AS, Jacobs JJ, Black J, Galante JO, Glant TT: Pro- and anti-inflammatory mediators secreted from interfacial membranes obtained at revision total hip arthroplasty. In: The Implant/Bone Interface (Eds. Buchorn GH, Willert H-G), Hogrefe & Huber Publishers, Gottingen, 1993 (In press).
37. Jacobs JJ, Urban RM, Glant TT, Galante JO: Clinical implications of osteolysis. In: Total Hip Revision Surgery (Eds. Galante JO, Rosenberg A), Raven Press, New York, 1994 pp. 81-90.
38. Ralph P: Established cell lines as a source of functional macrophages. In: Manual of Macrophage Methodology. Collection, Characterization, and Function (Eds. Herscowitz HB, Holden HT, Bellanti JAGhaffar A), Marcel Dekker, Inc., New York, 1981, pp. 51-59.
39. Mauel J, Defendi V: Infection and transformation of mouse peritoneal macrophages by a simian virus 40. J Exp Med 1971;134:335-350.
40. Chensue SW, Shymr-Forsch C, Otterness IG, Kunkel SL: The beta form is the dominant interleukin 1 released by murine peritoneal macrophages. Biochem Biophys Res Commun 1989;160:404-408.
41. Orencole SF, Dinarello CA: Characterization of a subclone (D10S) of the D10.G4.1 helper T-cell line which proliferates to attomolar concentrations of interleukin-1 in the absence of mitogens. Cytokine 1989;1:14-22.
42. Terebuh PD, Otterness IG, Stieter RM, Lincoln PM, Danforth JM, Kunkel SL, Chensue SW: Biologic and immunohistochemical analysis of interleukin-6 expression in vivo. Am J Pathol 1992;140:649-657.
43. Kelly RW, Graham BJM, O'Sullivan MJ: Measurement of PGE2 as the methyl oxime by radioimmunoassay using a novel iodinated label. Prostglandins Leukotrienes Essential Fatty Acids 1989;37:187-191.
44. Yao J, Eghbali M: Decreased collagen gene expression and absence of fibrosis in thyroid hormone-induced myocardial hypertrophy. Response of cardiac fibroblasts to thyroid hormone in vitro. Circul Res 1992;71:831-839.
45. Yao J, Lark MW, Hutchinson NI, Glant TT: The potential role of fibroblasts in periprosthetic osteolysis: response to titanium particulate in vitro. J Bone Miner. Res. 1995 (In press).
46. Paulsson Y, Bywater M, Heldin C-H, Westermark B: Effects of epidermal growth factor and platelet-derived growth factor on c-fos and c-myc mRNA levels in normal human fibroblasts. Exp Cell Res 1987;171:186-194.
47. Chomczynski P, Sacchi N: Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 1987;162:156-159.
48. Lehrach HD, Diamond D, Wozney JM, Boadtker H: RNA molecular weight determinations by gel electrophoresis under denaturing conditions, a critical reexamination. Biochemistry 1977;16:4743-4751.
49. Sambrook J, Fritsch EF, Maniatis T: Molecular Cloning: A Laboratory Manual, Cold Spring Harbor Laboratory Press, New York, 1989.
50. Soderdahl G, Betsholtz C, Johansson A, Nilsson K, Bergh J: Differential expression of platelet-derived growth factor and transforming growth factor genes in small- and non-small-cell human lung carcinoma lines. Int J Cancer 1988;41:636-641.
51. Tso JY, Sun X-H, Kao T-H, Reece KS, Wu R: Isolation and characterization of rat and human glyceraldehyde-3-phosphate dehydrogenase cDNAs: genomic complexity and molecular evolution of the gene. Nucleic Acids Res 1985;13:2485-2502.
52. MacNaul KL, Chartrain N, Lark M, Tocci MJ, Hutchinson NI: Discoordinate expression of stromelysin, collagenase, and tissue inhibitor of metalloproteinases-1 in rheumatoid human synovial fibroblasts. J Biol Chem 1990;265:17238-17245.
53. Innis MA, Gelfand DH, Sninsky JJ, White TJ: PCR Protocols. A Guide to Methods and Applications, Academic Press, New York, 1990, pp. 1-258.
54. Saiki RK, Scharf S, Faloona F, Mullis KB, Horn GT, Erlich HA, Arnheim N: Enzymatic amplification of B-globin genomic sequences and restriction site analysis for diagnosis of sickle cell anemia. Science 1985;230:1350-1354.
55. Baldino F, Jr., Chesselet M-F, Lewis ME: High-resolution in situ hybridization histochemistry. Methods Enzymol 1989;168:761-777.
56. Weiss LM, Chen Y-Y: Effects of different fixatives on detection of nucleic acids from paraffin-embedded tissues by in situ hybridization using oligonucleotide probes. J Histochem Cytochem 1991;39:1237-1242.
57. Sandell LJ, Morris N, Robbins JR, Goldring MB: Alternatively spliced type II procollagen mRNAs define distinct populations of cells during vertebral development: differential expression of the amino-propeptide. J Cell Biol 1991;114:1307-1319.
58. Jacobs JJ, Urban RM, Schajowicz F, Gavrilovic J, Galante JO: Particulate-associated endosteal osteolysis in titanium-base alloy cementless total hip replacement. In: Particulate Debris from Medical Implants: Mechanisms of Formation and Biological Consequences, ASTM STP 1144 (Eds. St. John KR), American Society for Testing and Materials, Philadelphia, 1992, pp. 52-60.
59. Jacobs JJ, Galante JO, Sumner DR: Local response to biomaterials: bone loss in cementless femoral stems. In: Institutional Course Lectures, Vol. 41, (Eds. Eilert R), American Academy of Orthopedic Surgeons, Park Ridge, IL, 1992, pp. 119-125.
60. Lee J-M, Salvati EA, Betts F, DiCarlo EF, Doty SB, Bullough PG: Size of metallic and polyethylene debris in failed cemented total hip replacements. J Bone Joint Surg 1992;74B:380-384.
61. Willert HG, Semlitsch M: Tissue reactions to plastic and metallic wear products of joint endoprostheses. In: Total Hip Prosthesis, (Eds. Gschwend N, Debrunner HU), Williams and Wilkins, Baltimore, 1976, pp. 205-239.
62. Willert HG, Semlitsch M: Reactions of the articular capsule to wear products of artificial joint prostheses. J Biomed Mater Res 1977;11:157-164.
63. Shanbhag AS, Glant TT, Jacobs JJ, Black J: Macrophage stimulation of fibroblastic proliferation is affected by size, composition and surface area of particulates. Trans ORS 1992;17:342.
64. Urban RM, Jacobs JJ, Gilbert JL, Galante JO: Migration of corrosion products from modular hip prostheses. Particle microanalysis and histopathological findings. J Bone Joint Surg 1994;76A (In press).
65. Kunkel SL, Chensue SW, Phan SH: Prostaglandins as endogenous mediators of endogenous mediators of interleukin 1 production. J Immunol 1986;136:186-192.
66. Akatsu T, Takahashi N, Udagawa N, Imamura K, Yamaguchi A, Sato K, Nagata N, Suda T: Role of prostaglandins in interleukin-1-induced bone resorption in mice in vitro. J Bone Miner Res 1991;6:183-190.
67. Yoneda T, Mundy GR: Prostaglandins are necessary for osteoclast-activating factor production by activated peripheral blood leukocytes. J Exp Med 1978;149:279-283.
68. Ishimi Y, Miyaura C, Jin CH, Akatsu T, Abe E, Nakamura Y, Yamaguchi A, Yoshiki S, Matsuda T, Hirano T, Kishimoto T, Suda T: IL-6 is produced by osteoblasts and induces bone resorption. J Immunol 1990;145:3297-3303.
69. Schindler R, Mancilla J, Endres S, Ghorbani R, Clarke SC, Dinarello CA: Correlations and interactions in the production of interleukin-6 (IL-6), IL-1 and tumor necrosis factor (TNF) in human blood mononuclear cells: IL-1 suppresses IL-1 and TNF. Blood 1990;75:40-47.
70. Dinarello CA: Interleukin-1 and interleukin-1 antagonism. Blood 1991;77(8):1627-1652.
71. Gowen M, Wood DD, Ihrie EJ, McGuire MKB, Russell RGG: An interleukin 1 like factor stimulates bone resorption in vitro. Nature 1983;306:378-380.
72. Boyce BF, Aufdemorte TB, Garrett IR, Yates AJP, Mundy GR: Effects of interleukin-1 on bone turnover in normal mice. Endocrinology 1989;125:1142-1150.
73. Skjodt H, Russell G: Bone cell biology and the regulation of bone turnover. In: Cytokines and Bone Metabolism (Ed. Gowen M), CRC Press, Boca Raton, FL, 1992, pp. 1-70.
74. Harvey W: Methodology. In: Prostaglandins in Bone Resorption (Eds. Harvey W, Bennett A), CRC Press, Boca Raton, FL, 1988, pp. 11-25.
75. Nishihara T, Ishihara Y, Noguchi T, Koga T: Membrane IL-1 induces bone resorption in organ culture. J Immunol 1989;143:1881-1886.
76. Goldberg GI, Wilhelm SM, Kronberger A, Bauer HCF, Grant GA, Eisen AZ: Human fibroblast collagenase. Complete primary structure and homology to an oncogene transformation-induced rat protein. J Biol Chem 1986;261:6600-6605.
77. Whitham SE, Murphy G, Angel P, Rahmsdorf H-J, Smith BJ, Lyons A, Harris TJR, Reynolds JJ, Herrlich P, Docherty AJP: Comparison of human stromelysin and collagenase by cloning and sequence analysis. Biochem J 1986;240:913-916.
78. Docherty AJP, Lyons A, Smith BJ, Wright EM, Stephens PE, Harris TJR, Murphy G, Reynolds JJ: Sequence of human tissue inhibitor of metalloproteinases and its identity to erythroid-potentiating activity. Nature 1985; 318:66-69.
79. Arcari P, Martinelli R, Salvatore F: The complete sequence of a full length cDNA for human liver glyceraldehyde-3-phosphate dehydrogenase: evidence for multiple mRNA species. Nucleic Acids Res 1984;12:9179-9189.
80. Kotenko SV, Bulenkov MT, Veiko VP, Epishin SM, Lomakin IB, Emel'yanov AV, Kozlov AP, Konusova VG, Kotov AY, Kurbatova TV, Reshetnikov VL, Simbirtsev AS, Ketlinskii SA, Vinetskii YP: Cloning of cDNAs coding for human prointerleukin-1 alpha and prointerleukin-1 beta. Dokl Akad Nauk SSSR 1989;309:1005-1008.
81. Hirano T, Yasukawa K, Harada H, Taga T, Watanabe Y, Matsuda T, Kashiwamura S, Nakajima K, Koyama K, Iwamatsu A, Tsunasawa S, Sakiyama F, Matsui H, Takahara Y, Taniguchi T, Kishimoto T: Complementary DNA for a novel human interleukin (BSF-2) that induces B lymphocytes to produce immunoglobulin. Nature 1986; 324:73-76.
82. Nedwin GE, Naylor SL, Sakaguchi AY, Smith D, Jarrett-Nedwin J, Pennica D, Goeddel DV, Gray PW: Human lymphotoxin and tumor necrosis factor genes: structure, homology and chromosomal localization. Nucleic Acids Res 1985;13:6361-6373.