Evidence for intraocular synthesis of kynurenic acid, a putative endogenous neuroprotectant

Ophthalmic Research

Volumn 33, Issue 2, 2001, Pages 107-110

  Zarnowski, Tomasz ^a   Rejdak, Robert ^a   Zagórski, Zbigniew ^a   Kocki, Tomasz ^a   Kleinrok, Zdzisław ^a   Turski, Waldemar A ^a,b  

^a MEDICAL UNIVERSITY OF LUBLIN   (Poland)

^b INSTITUTE OF AGRICULTURAL MEDICINE   (Poland)

Author keywords

Aminooxyacetic acid; In vivo; Kynurenic acid; Kynurenine pathway; N methyl D aspartate antagonist; Rabbit; Vitreous body

Indexed keywords

AMINOOXYACETIC ACID; KYNURENIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR;

AMINO ACID SYNTHESIS; ANIMAL CELL; ARTICLE; BINDING SITE; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MALE; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; RABBIT; RECEPTOR BINDING; VITREOUS BODY;

AMINOOXYACETIC ACID; ANIMALS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; ENZYME INHIBITORS; EXCITATORY AMINO ACID ANTAGONISTS; KYNURENIC ACID; LYASES; MALE; RABBITS; TRANSAMINASES; VITREOUS BODY;

EID: 0035107702     PISSN: 00303747     EISSN: None     Source Type: Journal    
DOI: 10.1159/000055653     Document Type: Article

References (25)

1. The kinurenine metabolic pathway in the eye: Studies on 3-hydroxykynurenine, a putative cataractogenic compound
2. Oxidation products of 3-hydroxykynurenine bind to lens proteins: Relevance for nuclear cataract
3. The modification of proteins by 3-hydroxykynurenine
4. UV filters in human lenses: Tryptophan catabolism
5. Cytotoxicity of 3-hydroxykynurenine in a neuronalhybrid cell line
6. Neuropharmacology of quinolinic and kynurenic acid
7. Kynurenic acid blocks neurotoxicity and seizures induced in rats by the related brain metabolite quinolinic acid
8. Kynurenines, glia and the pathogenesis of neurodegenerative disorders
9. Characterization of rat brain kynurenine aminotransferases I and II
10. Immuno-localization of kynurenine aminotransferase (KAT) in the rat medulla and spinal cord
11. Rat brain slices produce and liberate kynurenic acid upon exposure to L-kynurenine
12. Focal injection of aminooxyacetic acid produces seizures and lesions in rat hippocampus: Evidence for mediation by NMDA receptors
13. Aminooxyacetic acid produces excitotoxic lesions in the rat striatum
14. Seizures induced by aminooxyacetic acid in mice: Pharmacological characteristics
15. Identification and quantification of kynurenic acid in human brain tissue
16. Fluorimetric micro-determination of kynurenic acid, an endogenous blocker of neurotoxicity, by high-performance liquid chromatography
17. Determination of extracellular kynurenic acid in the striatum of unanesthetized rats: Effect of amino-oxyacetic acid
18. Presence of kynurenic acid in the mammalian brain
19. +-independent transporter of neutral amino acids in astrocytes
20. Uptake of kynurenine into rat brain slices
21. Excitatory amino acid receptors of the retina: Diversity of subtypes and conductance mechanisms
22. The role of NMDA and non-NMDA excitatory amino acid receptors in the functional organization of primate retinal ganglion cells
23. Inciting excitotoxic cytocide among central neurons
24. Chronic low-dose glutamate is toxic to retinal ganglion cells. Toxicity blocked by memantine
25. Systemic L-kynurenine administration partially protects against NMDA, but not kainate-induced degeneration of retinal ganglion cells, and reduces visual discrimination deficits in adult rats