Etomidate-induced seizures? Investigation on human Kv 1.1 potassium channels;Epileptische anfälle durch etomidat? Untersuchung an Kv 1.1-kaliumkanälen des menschen

Anasthesiologie Intensivmedizin Notfallmedizin Schmerztherapie

Volumn 36, Issue 2, 2001, Pages 100-104

  Friederich, P ^a,b   Trellakis, S ^b   Urban, B W ^b  

^a UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

^b UNIVERSITY OF BONN   (Germany)

Author keywords

Epilepsy; Etomidate; Kv 1.1 potassium channels; Myoclonus

Indexed keywords

ETOMIDATE; POTASSIUM CHANNEL;

ARTICLE; DRUG EFFECT; DRUG INDUCED DISEASE; DRUG MECHANISM; ELECTROENCEPHALOGRAM; EPILEPTOGENESIS; HUMAN; HUMAN CELL; IC 50; PATCH CLAMP; SEIZURE;

CELLS, CULTURED; CLONING, MOLECULAR; ETOMIDATE; HUMANS; HYPNOTICS AND SEDATIVES; KV1.1 POTASSIUM CHANNEL; MEMBRANE POTENTIALS; PATCH-CLAMP TECHNIQUES; POTASSIUM CHANNEL BLOCKERS; POTASSIUM CHANNELS; POTASSIUM CHANNELS, VOLTAGE-GATED;

EID: 0035106938     PISSN: 09392661     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2001-11054     Document Type: Article

References (28)

1. Cerebral function under etomidate, a new non-barbiturate i.v. hypnotic
2. Clinical use of etomidate for anesthesia induction: A preliminary report
3. Activation of epileptogenic activity by etomidate
4. Effect of etomidate on the electroencephalogram of patients with epilepsy
5. Excitatory effects and electroencephalographic correlation of etomidate, thiopental, methohexital, and propofol
6. Reducing myoclonus after etomidate
7. Anesthetic mechanisms in-vitro and in general anaesthesia
8. Interaction of intravenous anesthetics with human neuronal potassium currents in relation to clinical concentrations
9. General anesthetic action at an internal protein site involving the S4-S5 cytoplasmic loop of a neuronal K(+) channel
10. A novel mutation in the human voltage-gated potassium channel gene (Kv 1.1) associates with episodic ataxia type 1 and sometimes with partial epilepsy
11. Functional characterization of a novel mutation in KCNA 1 in episodic ataxia type 1 associated with epilepsy
12. Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches
13. Pharmacokinetics of etomidate, a new intravenous anesthetic
14. Molecular diversity of K+ channels
15. A potassium channel mutation in neonatal human epilepsy
16. Deletion of the K(V)1.1 potassium channel causes epilepsy in mice
17. Etomidat unterdrückt einen menschlichen neuronalen kaliumstrom
18. Kv3.1 expression in human neuroblastoma SH-SY5Y cells
19. Pleiotropic effects of a disrupted K+ channel gene: Reduced body weight, impaired motor skill and muscle contraction, but no seizures
20. Episodic ataxia/myokymia syndrome is associated with point mutations in the human potassium channel gene, KCNA 1
21. Moderate loss of function of cyclic-AMP-modulated KCNQ2/KCNQ3 K+ channels causes epilepsy
22. Differential asparagine-linked glycosylation of voltage-gated K+ channels in mammalian brain and in transfected cells
23. The inhibition of human neuronal K+ currents by general anesthetic agents is altered by extracellular K
24. Extracellular calcium and potassium concentration changes in chronic epileptic brain tissue
25. Role of intrinsic burst firing, potassium accumulation, and electrical coupling in the elevated potassium model of hippocampal epilepsy
26. Extracellular K+ accumulation in the central nervous system