Integrins and signal transduction: Illustration with the αIIbβ3 integrin in platelets;L'intégrine αIIbβ3 dans les plaquettes sanguines: Un rôle dans la transduction des signaux

Medecine/Sciences

Volumn 17, Issue 2, 2001, Pages 155-161

  Missy, K ^a   Giuriato, S ^a   Bodin, S ^a   Plantavid, M ^a   Payrastre, B ^a  

^a CHU PURPAN   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA2B BETA3 INTEGRIN; INTEGRIN; MYOSIN ADENOSINE TRIPHOSPHATASE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4 BISPHOSPHATE; UNCLASSIFIED DRUG;

CONFORMATIONAL TRANSITION; HUMAN; HUMAN CELL; POSITIVE FEEDBACK; PROTEIN CONFORMATION; REVIEW; SIGNAL TRANSDUCTION; THROMBOCYTE; THROMBOCYTE ACTIVATION; THROMBOCYTE AGGREGATION;

EID: 0035105631     PISSN: 07670974     EISSN: None     Source Type: Journal    
DOI: 10.4267/10608/1887     Document Type: Review

References (51)

1. Integrin signaling: The platelet paradigm
2. Integrin αIIb/β3 signaling in platelet adhesion and aggregation
3. 3
4. Induction of the fibrinogen receptor on human platelets by intracellular mediators
5. Regulation of glycoprotein IIb-IIIa receptor function studied with platelets permeabilized by the pore-forming complement proteins C5b-9
6. Exposure of ligand-binding sites on platelet integrin αIIb/β3 by phosphorylation of the β3 subunit
7. Phosphatidylinositol 3,4,5-trisphosphate-dependent stimulation of phospholipase C-γ2 is an early key event in FcγRIIA-mediated activation of human platelets
8. A collagen-related peptide regulates phospholipaseCγ2 via phosphatidylinositol 3-kinase in human platelets
9. Phosphorylation of human platelet glycoprotein IIIa (GpIIIa). Dissociation from fibrinogen receptor activation and phosphorylation of GPIIIa in vitro
10. 3 (glycoprotein IIb-IIIa) in a variant of Glanzmann thrombastenia
11. 3 cytoplasmic domain in intact platelets
12. 3 integrin cytoplasmic tail
13. The platelet cytoskeleton regulates the affinity of the integrin for fibrinogen
14. IIb/β3 and its ligand and induces selective movements of ligand-occupied integrin
15. Participation de la cascade des gènes Rho à la régulation du cytosquelette: Rôle possible dans les mécanismes d'oncogenèse
16. Rho GTPases and the actin cytoskeleton
17. 3
18. Thrombin receptor ligation and activated. Rac uncap actin filament barbed ends through phosphoinositide synthesis in permeabilized human platelets
19. Signal transduction and cyclic nucleotides in human platelets
20. Protein kinase C and cyclic AMP regulate reversible exposure of binding sites for fibrinogen on the glycoprotein IIb-IIIa complex of human platelets
21. Identification of a novel, integrin signaling pathway involving the kinase Syk and the guanine nucleotide exchange factor Vav1
22. Integrin-dependent translocation of phosphoinositide 3-kinase to the cytoskeleton of thrombin-activated platelets involves, specific interactions of p85α with actin filaments and focal adhesion kinase
23. Interaction of pp60c-src, phospholipase C, inositol-lipid, and diacylglycerol kinases with the cytoskeletons of thrombin-stimulated platelets
24. Integrin-dependent tyrosine phosphorylation and cytoskeletal translocation of Tec in thrombin-stimulated platelets
25. Phosphoinositide 3-kinase and integrin signalling are involved in activation of Bruton Tyrosine Kinase in thrombin-stimulated platelets
26. Tyrosine phosphorylation and relocation of SHIP are integrin-mediated in thrombin-stimulated human blood platelets
27. pp60c-src associates with the SH2-containing inositol-5-phosphatase SHIP1 and is involved in its tyrosine phosphorylation downstream of integrin αIIbβ3 in human platelets
28. Integrin cytoplasmic tyrosine motif is required for outside-in αIIbβ3 signalling and platelet function
29. Outside-in signal transduction: αIIb/β3 (GpIIb-IIIa) tyrosine phosphorylation induced by platelet aggregation
30. Distinct involvement of beta3 integrin cytoplasmic domain tyrosine residues in integrin-mediated cytoskeletal assembly and phosphotyrosine signaling
31. Integrins and signaling transduction patways. The road taken
32. Phosphorylation of tyrosine 397 in focal adhesion kinase is required for binding phosphatidylinositol 3-kinase
33. Phosphoinositide 3-kinase inhibition spares actin assembly in activating platelets but reverses platelet aggregation
34. A key role of ADP in the irreversible platelet aggregation induced by the PAR1 activating peptide through the late activation of phosphoinositide 3-kinase
35. Signalling through the lipid products of phosphoinositide3-OH kinase
36. Phosphoinositide 3-kinases: A conserved family of signal transducers
37. Phosphoinositide 3-kinase activation and platelet function
38. 2+ or functional integrin
39. The novel inositol lipid phosphatidylinositol 3,4-bisphosphate is produced by human platelets upon thrombin stimulation
40. 3 integrin) in thrombin-induced synthesis of phosphatidylinositol 3′4′-bisphosphate
41. Molecular basis for ADP-reduced platelet activation. Evidence for three distinct ADP receptors on human platelets
42. Inositol polyphosphate 4-phosphatase is inactivated by calpain-mediated proteolysis in stimulated human platelets
43. A type II phosphoinositide 3-kinase is stimulated via activated integrin in platelets
44. Integrin take partners, cross-talk between integrins and other membrane receptors
45. Molecular cloning of integrin-associated protein: An immunoglobulin family member with multiple membrane-spanning domains implicated in alpha v beta 3-dependent ligand binding
46. Integrin-associated protein is a receptor for the C-terminal domain of thrombospondin
47. The thrombospondin receptor Integrin-associated protein (CD47) functionnally couples to heterotrimeric Gi
48. Thrombospondin acts via integrin-associated protein to activate the platelet integrin alphaIIb beta3
49. Role of cholesterol in formation and function of a signaling complex involving αvβ3, integrin-associated protein (CD47) and Heterotrimeric G proteins
50. Caveolae, DIGs, and the dynamics of sphingolipid-cholesterol microdomains
51. Role of urokinase receptor and caveolin in regulation of integrin signaling