Interindividual variations in levels and activities of cytochrome P-450 in liver microsomes of Chinese subjects

Acta Pharmacologica Sinica

Volumn 22, Issue 3, 2001, Pages 283-288

  Shu, Y ^a   Cheng, Z N ^a   Liu, Z Q ^a   Wang, L S ^a   Zhu, B ^a   Huang, S L ^a   Ou Yang, D S ^a   Zhou, H H ^a  

^a CENTRAL SOUTH UNIVERSITY   (China)

Author keywords

Cytochrome P 450 CYF3A4; Cytochrome P 450 CYP1A2; Cytochrome P 450 CYP2C9; Cytochrome P 450 CYP2D6; Liver microsomes; Metabolism; Mongoloid race

Indexed keywords

CYTOCHROME P450; CYTOCHROME P450 1A2; CYTOCHROME P450 2C9; CYTOCHROME P450 2D6; CYTOCHROME P450 3A4; DEBRISOQUINE; OMEPRAZOLE; PHENACETIN; TOLBUTAMIDE; CYP2C9 PROTEIN, HUMAN; CYP3A PROTEIN, HUMAN; CYTOCHROME P 450 CYP1A2; UNSPECIFIC MONOOXYGENASE;

ARTICLE; CELL LEVEL; CHINESE; CLINICAL ARTICLE; CONTROLLED STUDY; DENSITOMETRY; DRUG METABOLISM; ENZYME ACTIVITY; ETHNIC DIFFERENCE; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOBLOTTING; LIVER MICROSOME; MALE; SEX DIFFERENCE; CHINA; COMPARATIVE STUDY; ENZYMOLOGY; ETHNIC GROUP; METABOLISM; MONGOLOID RACE;

ARYL HYDROCARBON HYDROXYLASES; CHINA; COMPARATIVE STUDY; CYTOCHROME P-450 CYP1A2; CYTOCHROME P-450 ENZYME SYSTEM; ETHNIC GROUPS; FEMALE; HUMAN; MALE; MICROSOMES, LIVER; MONGOLOID RACE; SEX FACTORS; SUPPORT, NON-U.S. GOV'T;

EID: 0035105093     PISSN: 02539756     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (23)

1. P450 superfamily: Update on new sequences, gene mapping, accession numbers and nomenclature
2. The human hepatic cytochrome P450 involved in drug metabolism
3. Human cytochromes P450: Problems and prospects
4. The role of individual human cytochromes P450 in drug metabolism and clinical response
5. Interindividual variations in human liver cytochrome P-460 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: Studies with liver microsomes of 30 Japanese and 30 Caucasians
6. Relationship between CYP2C9 and 2C19 genotypes and tolbutamide methyl hydroxylation and S-mephenytoin 4′-hydroxylation activities in livers of Japanese and Caucasian populations
7. Comparison of monooxygenase activities and cytochrome P-450 isozyme concentrations in human liver microsomes
8. Comparison of levels of several human microsomal cytochrome P-450 enzymes and epoxide hydroxylase in normal and disease states using immunochemical analysis of surgical liver samples
9. Ethnic differences in drug disposition and responsiveness
10. Enzyme kinetic analysis and inhibition of amitriptyline N-demethylation in human liver microsomes in vitro
11. Protein measurement with the Folin phenal reagent
12. The carbon monoxide-binding pigment of liver microsomes. I. Evidence for its hemoprotein nature
13. Probing CYP2C19 and CYP3A4 activities in Chinese liver microsomes by quantification of 5-hydroxyomeprazole and omeprazole sulphone
14. Improved high-performance liquid chromatographic determination of debrisoquine and 4-hydroxydebrisoquine in human urine following direct injection
15. Drug biotransformation
16. Recent advances in understanding the molecular basis of polymorphisms in genes encoding cytochrome P450 enzymes
17. Genetic polymorphism in the 5′-flanking region of human CYP1A2 gene: Effect on the CYP1A2 inducibility in humans
18. Functional significance of a C → A polymorphism in intron 1 of the cytochrome P450 CYP1A2 gene tested with caffeine
19. Phenotypic polymorphism and gender-related differences of CYP1A2 activity in a Chinese population
20. Estimation of cytochrome P-450 CYP1A2 activity in 863 healthy Caucasians using a saliva-based caffeine test
21. Human drug metabolism in vivo
22. Studies on the expression and metabolic capacibilities of human liver cytochrome P450IIIA5 (HLp3)
23. Evidence for the effect of gender on activity of S-mephenytoin 4′-hydroxylase (CYP2C19) in a Chinese population