P53 autoantibodies in sera of patients with a colorectal cancer and their association to p53 protein concentration and p53 immunohistochemistry in tumor tissue

International Journal of Colorectal Disease

Volumn 16, Issue 1, 2001, Pages 22-27

  Broll, R ^a   Duchrow, M ^a   Oevermann, E ^a   Wellm, C ^a   Schwandner, O ^a   Schimmelpenning, H ^a   Roblick, U J ^a   Bruch, H P ^a   Windhovel U ^a  

^a UNIVERSITY HOSPITAL SCHLESWIG HOLSTEIN   (Germany)

Author keywords

Colorectal cancer; P53 autoantibodies; P53 immunohistochemistry; P53 protein concentration; Tumor suppressor gene p53

Indexed keywords

AUTOANTIBODY; PROTEIN P53; TUMOR MARKER;

ADULT; AGED; ANTIBODY DETECTION; ANTIBODY PRODUCTION; ARTICLE; BLOOD ANALYSIS; CANCER PATIENT; CANCER SURVIVAL; CANCER TISSUE; COLORECTAL CANCER; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FOLLOW UP; GENE OVEREXPRESSION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; MALE; PATIENT MONITORING; PREOPERATIVE EVALUATION; PRIORITY JOURNAL; PROGNOSIS; PROTEIN ANALYSIS; PROTEIN CONTENT; PROTEIN EXPRESSION; SENSITIVITY AND SPECIFICITY; SERODIAGNOSIS; SERUM; STATISTICAL ANALYSIS; TUMOR SUPPRESSOR GENE; TUMOR VOLUME;

ADENOCARCINOMA; ADULT; AGED; AGED, 80 AND OVER; AUTOANTIBODIES; COLORECTAL NEOPLASMS; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MIDDLE AGED; PROBABILITY; PROGNOSIS; PROSPECTIVE STUDIES; REFERENCE VALUES; SENSITIVITY AND SPECIFICITY; SURVIVAL ANALYSIS; TUMOR MARKERS, BIOLOGICAL; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0035103731     PISSN: 01791958     EISSN: None     Source Type: Journal    
DOI: 10.1007/s003840000263     Document Type: Article

References (24)

1. Multifactorial analysis of p53 alteration in human cancer: A review
2. Detection of antibodies against the cellular protein p53 in sera from patients with breast cancer
3. Coexpression of p53- and mdm2-mRNA and protein in colorectal carcinomas
4. Anti-p53 autoantibodies in colon cancer patients
5. p53 genetic alterations, protein expression and autoantibodies in human colorectal carcinoma: A comparative study
6. Characterisation and clinicopathological correlates of serum anti-p53 antibodies in breast and colon cancer
7. Antibodies against p53 are associated with poor prognosis of colorectal cancer
8. Correlations between p53-protein accumulation, serum antibodies and gene mutation in colorectal cancer
9. Immune response to p53 is dependent upon p53/HSP70 complexes in breast cancers
10. Prognostic significance of circulating P53 antibodies in patients in undergoing surgery for locoregional breast cancer
11. The immune response to p53 in breast cancer patients is directed against immunodominant epitopes unrelated to the mutational hot spot
12. Absence of p53 autoantibodies in a significant proportion of breast cancer patients
13. The relationship between serum p53 autoantibodies and characteristics of human breast cancer
14. Clinical implications of serum anti-p53 antibodies for patients with gastric carcinoma
15. Serum anti-p53 antibodies in gastric adenocarcinoma patients are associated with poor prognosis, lymph node metastasis and poorly differentiated nuclear grade
16. Circulating anti-p53 antibodies in esophageal cancer patients are found predominantly in individuals with p53 core domain mutations in their tumors
17. Detection of the anti-p53 antibody response in malignant and benign pancreatic disease
18. Development of antibodies against p53 in lung cancer patients appears to be dependent on the type of p53 mutation
19. p53 antibodies in patients with various types of cancer: Assay, identification, and characterization
20. Prevalence of serum antibodies against the p53 tumor suppressor gene protein in various cancers
21. Serum p53 antibodies as early markers of lung cancer
22. The humoral response to the tumor-suppressor gene-product p53 in human cancer: Implications for diagnosis and therapy
23. Analysis of the anti-p53 antibody response in cancer patients