Characterisation and clinicopathological correlates of serum anti-p53 antibodies in breast and colon cancer

Journal of Cancer Research and Clinical Oncology

Volumn 122, Issue 12, 1996, Pages 757-762

  Coomber, David ^a   Hawkins, Nicholas J ^b   Clark, Michelle ^a   Meagher, Alan ^a   Ward, Robyn L ^a  

^a ST VINCENT S HOSPITAL   (Australia)

^b UNIVERSITY OF NEW SOUTH WALES   (Australia)

Author keywords

breast neoplasms; colonic neoplasms; p53; serum antibodies

Indexed keywords

AUTOANTIBODY; PROTEIN P53; PROTEIN P53 ANTIBODY; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; BREAST CANCER; COLON CANCER; CONTROLLED STUDY; FEMALE; HUMAN; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL;

EID: 0029836926     PISSN: 01715216     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF01209124     Document Type: Article

References (29)

1. Acib-Conquy M, Avrameas S, Ternynck T (1993) Monoclonal IgG and IgM autoantibodies obtained after polyclonal activation, show reactivities similar to those of polyclonal natural autoantibodies. Mol Immunol 30:119-127
2. Angelopoulou K, Diamandis E, Sutherland D, Kellen J, Bunting P (1994) Prevalence of serum antibodies against the p53 tumor suppressor gene protein in various cancers. Int J Cancer 58:480-487
3. Avrameas S and Ternynck T (1993) The natural autoantibodies system: between hypotheses and facts. Mol Immunol 30:1133-42
4. Ben-Mahrez K, Sorokine I, Thierry D, Kawasumi T, Ishii S, Salmon R, Kohiyama M (1990) Circulating antibodies against c-myc oncogene in sera of colorectal cancer patients. Int J Cancer 46:35-38
5. Brown RE, Jarvis KL, Hyland KJ (1989) Protein measurement using bicinchoninic acid: elimination of interfering substances. Anal Biochem 180:136-139
6. Caron De Fromentel C, May-Leven F, Mouriesse H, Lemerle J, Chandrasekaran K, May P (1987) Presence of circulating antibodies against cellular protein p53 in a notable proportion of children with B-cell lymphoma. Int J Cancer 39:185-189
7. Casali P and Notkins AL (1989) CD5 + B lymphocytes, polyreactive antibodies and the human B cell repertoire. Immunol Today 10:365-8
8. Costa A, Maraska R, Valentinis B, Savarino M, Farada A, Silvestrini R, Torelli G (1995) p53 gene point mutations in relation to p53 nucleoprotein accumulation in colorectal cancers. J Pathol 176:45-53
9. Cotran RS, Kumar V, Robbins SL, (eds). (1994) Pathological basis of disease, 5th edn. Saunders, Philadelphia
10. Crawford L, Pim D, Bulbrook R (1982) Detection of antibodies against the cellular protein p53 in the serum from patients with breast cancer. Int J Cancer 30:403-408
11. Davidoff AM, Dirk Inglehart J, Marks JR (1992) Immune response to p53 is dependent upon p53/HSP70 complexes in breast cancers. Proc Natl Acad Sci USA 89:3439-3442
12. Disis M, Calenoff E, McLaughlin G, Murphy A, Chen W, Groner B, Jeschke M, Lydon N, McGlynn E, Livingston R, Moe R, Cheever M (1994) Existent T-cell and antibody immunity to Her-2/neu protein in patients with breast cancer Cancer Res 54:16-20
13. Dong X, Hamilton K, Satoh M, Wang J, Reeves W (1994) Initiation of autoimmunity to the p53 tumour suppressor protein by complexes of p53 and SV40 large T antigen. J Exp Med 17:1243-1252
14. Dougan G, Sherratt D (1977) The transposon Tn1 as a probe for studying ColE1 structure and function. Mol Gen Genet 151:151-160
15. Houbiers JGA, Van de Berg SH, Watering LMG van de, Tollenaar RAEM, Brand A, Velde CJH van de, Melief CJM (1995) Antibodies against p53 are associated with poor prognosis of colorectal cancer. Br J Cancer 72:637-641
16. Kotera Y, Fontenot J, Pecher G, Metzgar R, Finn O (1994) Humoral immunity against a tandem repeat epitope of human mucin MUC-1 in sera from breast, pancreatic, and colon cancer patients. Cancer Res 54:2856-2860
17. Laemmli K (1970) Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227:680-685
18. Levine L, Momand J, Finlay C (1991) The tumour suppressor gene. Nature 351:453-456
19. Lubin R, Schlichtholz B, Bengoufa D, et al. (1993) Analysis of p53 antibodies in patients with various cancers define B-cell epitopes of human p53: distribution on primary structure and exposure on protein surface. Cancer Res 53:5872-5876
20. Mudenda B, Green J, Green B, Jenkins J, Robertson L, Tarunina M, Leinster S (1994) The relationship between serum p53 antibodies and characteristics of human breast cancer. Br J Cancer 69:1115-1119
21. Nigro JM, Baker SJ, Preisinger AC, Jessup JM, Hostetter R, Cleary K, Bigner SH, Davidson N, Baylin S, Devilee P, et al. (1989) Mutations in the p53 gene occur in diverse human tumour types. Nature 342:705-708
22. Old LJ (1981) Cancer Immunology: the search for specificity. Cancer Res 41:361-375
23. Pupa SM, Menard S, Andreola S, Colnaghi MI (1993) Antibody response against the c-erbB-2 oncoprotein in breast carcinoma patients. Cancer Res 53:5864-5866
24. Purdie CA, O'Grady J, Piris J, Wyllie AH, Bird CC (1991) p53 expression in colorectal tumors. Am J Pathol 138:807-813
25. Sancar A, Wharton RP, Seltzer S, Kacinsky BM, Clark ND, Rupp WD (1981) Identification of the uvrA gene product. J Mol Biol 184:45-62
26. Schlichtholz B, Legros Y, Gillet D, Gailard C, Marty M, Lane D, Calvo F, Soussi T (1992) The immune response to p53 in breast cancer patients is directed against immunodominant epitopes unrelated to the mutational hotspot. Cancer Res 52:6380-6384
27. Sorokine I, Ben-Mahrez K, Sorokine I, Braconne A, Thierry D, Imamoto K, Ishii S, Kohiyama M (1991) Presence of circulating anti-c-myb oncogene product antibodies in human serum. Int J Cancer 47:665-669
28. Towbin H, Staehelin T, Gordon J (1979) Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets. Proc Natl Acad Sci USA 76:4350-4354
29. Winter SF, Minna JD, Johnson BE, Takahashi T, Gazdar AF, Carbone DP (1992) Development of antibodies against p53 in lung cancer patients appears to be dependent on the type of p53 mutation. Cancer Res 52:4168-4174