Reassessment of the location of the thyrotropin receptor 50 amino acid "insertion" provides evidence in favor of a second downstream cleavage site

Thyroid

Volumn 11, Issue 2, 2001, Pages 111-114

  Tanaka, K ^a   Chazenbalk, G D ^a   Rapoport, B ^a   McLachlan, S M ^a  

^a CEDARS SINAI MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; THYROTROPIN RECEPTOR;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; BETA CHAIN; DISULFIDE BOND; DNA FLANKING REGION; GENE DELETION; GENE INSERTION; GENE LOCATION; NONHUMAN; PRIORITY JOURNAL; SEQUENCE HOMOLOGY;

EID: 0035100258     PISSN: 10507256     EISSN: None     Source Type: Journal    
DOI: 10.1089/105072501300042721     Document Type: Article

References (15)

1. The thyrotropin receptor: Interaction with thyrotropin and autoantibodies
2. The lutropin/choriogonadotropin receptor: 4 years later
3. Evidence that the thyrotropin receptor ectodomain contains not one, but two, cleavage sites
4. Sequential cleavage and excision of a segment of the thyrotropin receptor ectodomain
5. An N-linked glycosylation motif from the non-cleaving luteinizing hormone receptor substituted for the homologous region (Gly-367 to Glu-369) of the thyrotropin receptor prevents cleavage at its second, downstream site
6. Thyrotropin receptor cleavage at site 1 does not involve a specific amino acid motif but instead depends on the presence of the unique, 50 amino acid insertion
7. Molecular cloning, sequence and functional expression of the cDNA for the human thyrotropin receptor
8. Molecuar cloning of the thyrotropin receptor
9. Immunoglobulins from Graves' disease patients interact with different sites on TSH receptor/LH-CG receptor chimeras than either TSH or immunoglobulins from idiopathic myxedema patients
10. Both the 5' and 3' non-coding regions of the thyrotropin receptor messenger RNA influence the level of receptor protein expression in transfected mammalian cells
11. An insertion in the human thyrotropin receptor critical for high affinity hormone binding
12. On the functional importance of thyrotropin receptor intramolecular cleavage
13. DNA sequencing with chain terminating inhibitors
14. Cleavage of structural proteins during the assembly of the head of bacteriophage T4
15. Thyrotropin-luteinizing hormone/chorionic gonadotropin receptor extracellular domain chimeras as probes for TSH receptor function