Umbilical cord blood progeny cells that retain a CD34+ phenotype after ex vivo expansion have less engraftment potential than unexpanded CD34+ cells

Transfusion

Volumn 41, Issue 2, 2001, Pages 213-218

  Xu, Ruiling ^a   Anna Reems, Jo ^a,b  

^a Blood Systems Laboratories   (United States)

^b Northwest Tissue Center   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL CELL; ARTICLE; COMBINED IMMUNODEFICIENCY; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PHENOTYPE; STEM CELL TRANSPLANTATION; UMBILICAL CORD BLOOD;

ANIMALS; ANTIGENS, CD34; CELLS, CULTURED; FETAL BLOOD; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMANS; MICE; MICE, INBRED NOD; MICE, SCID; PHENOTYPE;

EID: 0035099741     PISSN: 00411132     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1537-2995.2001.41020213.x     Document Type: Article

References (22)

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7. Extensive amplification and self-renewal of human primitive hematopoietic stem cells from cord blood
8. Engraftment in nonobese diabetic severe combined immunodeficient mice of human CD34(+) cord blood cells after ex vivo expansion: Evidence for amplification and self-renewal of repopulating stem cells
9. Differential modulation of adhesion markers with ex vivo expansion of human umbilical CD34+ progenitor cells
10. Processing and cryopreservation of placental/umbilical cord blood for unrelated bone marrow reconstitution
11. High gradient magnetic cell separation with MACS
12. Long-term culture of human bone marrow cells
13. Enzymatic treatment of long-term human marrow cultures reveals the preferential location of primitive hemopoietic progenitors in the adherent layer
14. Enhanced detection, maintenance, and differentiation of primitive human hematopoietic cells in cultures containing murine fibroblasts engineered to produce human steel factor, interleukin-3, and granulocyte colony-stimulating factor
15. Expansion in vitro of transplantable human cord blood stem cells demonstrated using a quantitative assay of their lympho-myeloid repopulating activity in nonobese diabetic-scid/scid mice
16. Quantitative analysis reveals expansion of human hematopoietic repopulating cells after short-term ex vivo culture
17. Expansion of human cord blood CD34(+)CD38(-) cells in ex vivo culture during retroviral transduction without a corresponding increase in SCID repopulating cell (SRC) frequency: Dissociation of SRC phenotype and function
18. Differential kinetics of primitive hematopoietic cells assayed in vitro and in vivo during serum-free suspension culture of CD34+ blood progenitor cells
19. Differential maintenance of primitive human SCID-repopulating cells, clonogenic progenitors, and long-term culture-initiating cells after incubation on human bone marrow stromal cells
20. Assay of human stem cells by repopulation of NOD/SCID mice
21. Evaluation of clinical scale CD34+ cell purification: Experience of 71 immunoaffinity column procedures
22. Peripheral blood CD34+ cell immunomagnetic selection in breast cancer patients: Effect on hematopoietic progenitor content and hematologic recovery after high-dose chemotherapy and autotransplantation