Direct detection of cellular immune responses to cancer vaccines

Surgery

Volumn 129, Issue 3, 2001, Pages 248-254

  Mosca, Paul J ^a   Hobeika, Amy C ^a   Clay, Timothy M ^a   Morse, Michael A ^a   Lyerly, H Kim ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CANCER VACCINE;

ANTIGEN SPECIFICITY; CANCER IMMUNOTHERAPY; CELLULAR IMMUNITY; DRUG RESPONSE; HUMAN; IMMUNE RESPONSE; MALIGNANT NEOPLASTIC DISEASE; NONHUMAN; PRIORITY JOURNAL; REVIEW; T LYMPHOCYTE ACTIVATION;

EID: 0035099076     PISSN: 00396060     EISSN: None     Source Type: Journal    
DOI: 10.1067/msy.2001.108609     Document Type: Article

References (18)

1. Active specific immunotherapy for stage II and stage III human colon cancer: A randomised trial
2. Increased vaccine-specific T cell frequency after peptide-based vaccination correlates with increased susceptibility to in vitro stimulation but does not lead to tumor regression
3. Monitoring specific T-cell responses to melanoma vaccines: ELISPOT, tetramers, and beyond
4. A flow cytometric method to estimate the precursor frequencies of cells proliferating in response to specific antigens
5. Determination of antigen-specific memory/effcctor CD4+ T cell frequencies by flow cytometry: Evidence for a novel antigen-specific homeostatic mechanism in HIV-associated immunodeficiency
6. Functional analysis of antigen-specific T lymphocytes by serial measurement of gene expression in peripheral blood mononuclear cells and minor specimens
7. A novel method for measuring CTL and NK cell-mediated cytotoxicity using annexin V and two-color flow cytometry
8. Quantification of antigen-reactive cells among human T lymphocytes
9. Phenotypic analysis of antigen-specific T lymphocytes
10. Tumor-specific immune response: Current in vitro analyses may not reflect the in vivo immune status
11. Quantitation of T-cell receptor frequencies by competitive PCR: Generation and evaluation of novel TCR subfamily and clone specific competitors
12. A sensitive ELISPOT assay to detect low-frequency human T lymphocytes
13. Evaluation of the modified ELISPOT assay for gamma interferon production in cancer patients receiving antitumor vaccines
14. A re-evaluation of the frequency of CD8+ T cells specific for EBV in healthy virus carriers
15. Direct visualization of antigen-specific CD8+ T cells during the primary immune response to Epstein-Barr virus in vivo
16. Characterization of circulating T cells specific for tumor-associated antigens in melanoma patients
17. Frequency analysis of recipient-reactive helper and cytotoxic T lymphocyte precursors using a combined single limiting dilution assay
18. Detection of antigen-specific T cell cytokine expression in whole blood by flow cytometry