Expression of killer cell inhibitory receptors is restricted to true NK cell lymphomas and a subset of intestinal enteropathy-type T cell lymphomas with a cytotoxic phenotype

Journal of Clinical Pathology

Volumn 54, Issue 3, 2001, Pages 224-228

  Dukers, D F ^a   Vermeer, M H ^a   Jaspars, L H ^a   Sander, C A ^b   Flaig, M J ^b   Vos, W ^a   Willemze, R ^a   Meijer, C J L M ^a  

^a VU UNIVERSITY AMSTERDAM   (Netherlands)

^b LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

Author keywords

CD94; Granzyme B; Killer inhibitory receptors; Lymphoma

Indexed keywords

CD94 ANTIGEN; CELL RECEPTOR; GRANZYME B; MONOCLONAL ANTIBODY; TUMOR ANTIGEN;

ARTICLE; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; CYTOTOXICITY; ENTEROPATHY; HUMAN; HUMAN TISSUE; NATURAL KILLER CELL; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; T CELL LYMPHOMA; TISSUE DISTRIBUTION; TUMOR LOCALIZATION;

ANTIGENS, CD3; ANTIGENS, CD56; HUMANS; IMMUNOENZYME TECHNIQUES; IMMUNOPHENOTYPING; INTESTINAL NEOPLASMS; KILLER CELLS, NATURAL; LYMPHOMA; LYMPHOMA, T-CELL; NASOPHARYNGEAL NEOPLASMS; NEOPLASM PROTEINS; RECEPTORS, IMMUNOLOGIC; SKIN NEOPLASMS; T-LYMPHOCYTES, CYTOTOXIC;

EID: 0035092417     PISSN: 00219746     EISSN: None     Source Type: Journal    
DOI: 10.1136/jcp.54.3.224     Document Type: Article

References (28)

1. Extranodal peripheral T-cell and NK-cell neoplasms
2. Production and characterization of monoclonal antibodies raised against recombinant human granzymes A and B showing cross reactions with the natural proteins
3. + T-lymphocytes
4. Granzyme B expressing peripheral T-cell lymphomas: Neoplastic equivalents of activated cytotoxic T-cells with preference for mucosa associated lymphoid tissue (MALT) localization
5. Enteropathy-associated T cell lymphomas have a cytotoxic T-cell phenotype
6. Anaplastic large cell lymphomas of T-cell and null cell phenotype express cytotoxic molecules
7. Cytotoxic cell antigen expression in anaplastic large cell lymphomas of T- and null cell type and Hodgkins disease: Evidence for distinct cellular origin
8. Most primary cutaneous CD30 positive lymphoproliferative disorders have a CD4 positive cytotoxic T-cell phenotype
9. A cytotoxic phenotype does not predict clinical outcome in anaplastic large cell lymphomas
10. Granzyme B expression in Reed-Sternberg cells of Hodgkin's disease
11. Expression of cytotoxic proteins by neoplastic T cells in mycosis fungoides increases with progression from plaque stage to tumour stage disease
12. + NK cells by the expression of clonally distributed surface molecules. Correlation between subset assignment of NK clones and ability to mediate specific allo antigen recognition
13. Human NK receptors: Origin, clonality specificity and receptors
14. HLA class I specific inhibitory receptors
15. Molecular clones of the p58 NK cell receptor reveal immunoglobulin-related molecules with diversity in both the extra- and intracellular domains
16. HLA-E is a major ligand for the NK inhibitory receptor CD94/NKG2a
17. - T lymphocyte subsets that express HLA I-specific inhibitory receptors represent oligoclonally or monoclonally expanded cell populations
18. - T lymphocytes. Antigenic and functional properties
19. - cytolytic effector T cells frequently express NK receptors and are present at variable proportions in circulating lymphocytes from healthy donors and melanoma patients
20. The World Health Organisation classification of neoplastic diseases of the hematopoeietic and lymphoid tissues. Report of the clinical advisory committee meeting - Airlie House, Virginia
21. EORTC classification for primary cutaneous lymphomas - A proposal from the cutaneous lymphoma study group of the European Organization for Research and Treatment of Cancer
22. Presence of Epstein-Barr virus harbouring small and intermediate-sized cells in Hodgkin's disease: Is there a relationship with Reed-Sternberg cells?
23. Granzyme B expression in Reed-Sternberg cells of Hodgkin's disease
24. Catalyzed reporter deposition, a novel method of signal amplification. I. Application to immunoassays
25. Catalyzed reporter deposition, a novel method of signal amplification. II. Application to membrane immunoassays
26. HLA-class I specific inhibitory receptors in human cytolytic T lymphocytes. Molecular characterization, distribution in lymphoid tissues and coexpression by individual T cells
27. Expression of CD94/NKG2A and killer immunoglobulin-like receptors in NK-cell and a subset of extranodal cytotoxic T-cell lymphomas
28. Functionally and structurally distinct NK cell receptor repertoires in the peripheral blood of two human donors