Secretion of a lactone-hydrogenated ouabain-like effector of sodium, potassium-adenosine triphosphatase activity by adrenal cells

Endocrinology

Volumn 141, Issue 9, 2000, Pages 3200-3209

  Qazzaz, Hassan M A M ^a   El Masri, M Adnan ^a   Valdes Jr , Roland ^a  

^a University of Louisville School of Medicine   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); CARDENOLIDE; DIGITALIS LIKE FACTOR; DIHYDROOUABAIN;

ADRENAL CELL; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CATTLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; HORMONAL REGULATION; HORMONE STRUCTURE; IMMUNOHISTOCHEMISTRY; NONHUMAN; PRIORITY JOURNAL;

EID: 0034455716     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/endo.141.9.7664     Document Type: Article

References (48)

1. Ouabain-like factor
2. Endogenous digitalis-like factor
3. The endogenous digitalis-like factor
4. Circulating bufadienolide and cardenolide sodium pump inhibitors in preeclampsia
5. Proscillaridin A immunoreactivity: Its purification, transport in blood by a specific binding protein and its correlation with blood pressure
6. Bufadienolides as endogenous Na, K-ATPase inhibitors: Biosynthesis in bovine and rat adrenals
7. +-ATPase α subunit: Site-directed mutagenesis of glutamine-111 to arginine and asparagine-122 to aspartic acid generates a ouabain-resistant enzyme
8. Overview: Subunit diversity in the Na,K-ATPase
9. Endogenous sodium pump inhibitors and blood pressure regulation: An update on recent progress
10. Brain 'ouabain' in the median preoptic nucleus mediates sodium-sensitive hypertension in spontaneously hypertensive rats
11. Endogenous sodium pump inhibition: Current status and therapeutic opportunities
12. Understanding the sodium pump and its relevance to disease
13. Endogenous ouabain: Physiological activity and pathophysiological implications
14. Endogenous ouabain: Role in the pathogenesis of hypertension
15. Endogenous ouabain, sodium balance and blood pressure: A review and a hypothesis
16. Sodium transport inhibitors and hypertension
17. +-ATPase and heart excitability
18. Identification and characterization of a ouabain-like compound from human plasma
19. Is ouabain an Authentic endogenous mammalian substance derived from the adrenal?
20. Bovine adrenocortical cells in culture synthesize an ouabain-like compound
21. Deglycosylated products of endogenous digoxin-like immunoreactive factor (DLIF) in mammalian tissue
22. Evidence for the presence of a reduced form of digoxin-like immunoreactive factor (dihydro-DLIF) in mammalian tissue
23. Simultaneous isolation of endogenous digoxin-like immunoreactive factor (DLIF), ouabain-like factor (OLF), and deglycosylated congeners from mammalian tissues
24. Development of an immunoassay for endogenous digitalislike factor
25. +- ATPase inhibitors
26. +-ATPase isoforms to oxidants
27. Isolation of two chromatographically and biologically distinct components from a dihydroouabain commercial preparation
28. Two bilogically active isomers of dihydroouabain isolated from a commercial preparation
29. An antiserum for detection of a newly discovered dihydroouabain-like factor (dihydro-OLF) isolated from mammals
30. The (Na,K)-activated ATPase. Enzymatic and transport properties
31. Bufadienolides of plant and animal origin
32. The measurement of urinary digoxin and dihydrodigoxin by radioimmunoassay and mass spectroscopy
33. Sodium pump isoform specificity for the digitalis-like factor isolated from human peitoneal dialysate
34. Endogenous digoxin-like immunoreactive factors: Impact on digoxin measurements and potential physiological implications
35. Preliminary characterization of DLIF-binding protein from human serum
36. Specific binding protein for cardiac glycosides exists in bovine serum
37. Further evidence for an endogenous digitalis-like compound in human plasma
38. Characterization of ouabain-like immunoreactivity in human urine
39. Ouabain-like factor quantification in mammalian tissues and plasma, comparison of two independant assays
40. Development of enzyme immunoassay for endogenous ouabain-like compound in human plasma
41. Human placenta radioactive assay with digoxin and ouabain to detect endogenous digitalis-like factor(s) in human plasma and urine
42. Physicochemical characterization of a ouabain isomer from bovine hypothalamus
43. +-ATPase inhibitors from bovine hypothalamus and human plasma are different from ouabain. Nanogram scale CD structural analysis
44. Analysis of amino acid residues in the H5-H6 transmembrane and extracellular domains of Na,K-ATPase α subunit identifies threonine 797 as a determinant of ouabain sensitivity
45. Digitalis: Its mode of action, receptor, and structure-activity relationships
46. Molecular cloning of three distinct forms of the Na, K, ATPase alpha subunit from rat brain
47. Hydrogenation of digitalis genins and anhydrogenins
48. Digoxin-inactivating bacteria: Identification in human gut flora